A probabilistic seismic hazard analysis (PSHA) for Western Anatolia is presented using the Gutenberg-Richter (G-R) frequency-magnitude relation. Since the modeling is sensitive to the location of seismotectonics boundaries, to use the information content of the observed earthquake data, as a general rule the borders of the affected area are extended. In this study, the effect of the region's definition on the G-R model is debated on the Western Anatolian region, which is one of the most seismically active and rapidly deforming regions of the world throughout the ages. Calculations are carried out for two subregions and one combined region as a whole using the seismic catalog from 1900 to 2005. The data sets are determined by the region's borders with the parameters computed according to these data sets by the least-squares and maximum likelihood methods, and then future predictions are estimated via these parameters. Comparing the results with historical earthquake records, most appropriate regional borders for Western Anatolia are defined, and for this new region G-R model parameters are obtained.