2012
DOI: 10.7150/ijbs.3897
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Selection of Peptide Inhibitor to Matrix Metalloproteinase-2 Using Phage Display and Its Effects on Pancreatic Cancer Cell lines PANC-1 and CFPAC-1

Abstract: Despite tremendous advances in cancer treatment and survival rates, pancreatic cancer remains one of the most deadly afflictions and the fourth leading cause of cancer deaths in the world. Matrix Metalloproteinases (MMPs) are thought to be involved in cancer progression. Matrix metalloproteinase (MMP)-2 is known to play a pivotal role in tumor invasion, metastasis and angiogenesis, and validated to be the anticancer target. Inhibition of MMP-2 activity is able to reduce the cancer cell invasion and suppress tu… Show more

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Cited by 25 publications
(18 citation statements)
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“…6 MMPs play a fundamental role in extracellular matrix degradation related to cancer cell invasion, tumor metastasis, and angiogenesis. 25 Among them, the MMP-2 and MMP-9 have been reported to be most closely associated with metastatic potential. 20 Cancer cell invasion and migration into surrounding tissues are mediated by MMP-2 and MMP-9.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…6 MMPs play a fundamental role in extracellular matrix degradation related to cancer cell invasion, tumor metastasis, and angiogenesis. 25 Among them, the MMP-2 and MMP-9 have been reported to be most closely associated with metastatic potential. 20 Cancer cell invasion and migration into surrounding tissues are mediated by MMP-2 and MMP-9.…”
Section: Resultsmentioning
confidence: 99%
“…LSGE did not affect the transcription of TIMP-2 DNA. Since prevention of invasion and metastasis is critical for successful cancer therapy, 28 and MMP-2 plays an important role in metastasis of human cancers, 25,29 MMP-2 has been considered an important therapeutic target for human cancers. 20,25,26,30 Further work is required to clarify the effect of LSGE on different molecular changes and signaling pathways related to tumor metastasis.…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, peptides can be selected that not only bind but also obstruct the function of its targets, such as demonstrated with peptides identified for inhibition of proteases such as human neutrophil elastase, 361 as well as cancer-associated matrix metalloproteinases. 362 …”
Section: Applications Of Virus-based Particlesmentioning
confidence: 99%
“…The most conclusive evidence of the role of MMP2 in PDAC progression comes from subcutaneous models, in which the injection of shMMP2-silenced PANC1 cells resulted in smaller tumors compared to the injection of control shRNA transduced cells [84], whereas treatment with MMP2-blocking peptides limited tumor growth and angiogenesis [85].…”
Section: Gelatinases In Pdacmentioning
confidence: 99%