Selective plasminogen binding: Cysteinyl–lysine–dextran protein interactions

Warkentin, Peter H.

doi:10.1016/s0142-9612(98)00086-6

Cited by 7 publications

(2 citation statements)

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“…As indicated above, it is known that plasminogen and t-PA bind specically to the surface of brin via carboxy-terminal lysine residues in which the carboxyl and 3-amino groups are free (referred to as "3-lysines"). 125,[207][208][209] Therefore, it is expected that an 3-lysine-enriched surface could provide a substrate for the capture of plasminogen and t-PA from blood; the interaction of these two molecules should then lead to plasmin formation and thus to brinolysis. 44,210 This concept was rst introduced by Brash and coworkers.…”

Section: Thrombomodulin-protein Cmentioning

confidence: 99%

Blood compatible materials: state of the art

et al. 2014

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Section: Thrombomodulin-protein Cmentioning

confidence: 99%

Blood compatible materials: state of the art

et al. 2014

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“…Recently,4, 5 a thromboresistant material obtained by photochemical attachment polyacrylamide bearing α‐aminocoupled lysine to polyurethane has been reported. A material based on dextran with covalently attached dipeptide l ‐cysteinyl‐ l ‐lysine was also prepared 6…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte thromboresistant affinity coatings for modification of devices contacting blood

Самойлова¹,

Krayukhina²,

Novikova³

et al. 2007

J Biomedical Materials Res

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The modification of hydrophobic polyethylene/polystyrene surfaces of medical devices with bilayer/multilayer coatings (BCs/MCs) based on polyelectrolyte complexes (PEC) of modified poly(N-vinylpyrrolidone-co-maleic acid) copolymer (VPMA) with chitosan, amphiphilic chitosan, or albumin was studied. The VPMA contained l-Lysine as affinity ligand for plasminogen attached through alpha-amino group. The surface properties and chemical composition of the surfaces investigated were analyzed, using sessile-drop water contact angle measurements, attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The specific adsorption of plasminogen (precursor of fibrinolytic enzyme plasmin) from its solutions and from human blood plasma on the modified surfaces was investigated. It was established that polyelectrolyte MCs are more efficient than single-layer BCs and the affine polymer coatings without interlayer. A thrombogenicity decrease for the materials modified with BCs and MCs was shown in in vitro and ex vivo trials.

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