Selective recognition of carbonic anhydrase using transition metal complexes

Roy, B. C.; Fazal, Md. Abul; Sun, Shuguang; Mallik, Sanku

doi:10.1039/a909001k

Cited by 10 publications

(6 citation statements)

References 20 publications

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“…Mallik et al designed cupric iminodiacetate chelate complexes which recognize the unique pattern of histidine residues on protein surfaces. [55][56][57][58] For example, carbonic anhydrase contains five histidines exposed on its surface and molecular modeling led to the design of the tris-chelate 9 ( Fig. 4(d)), which binds carbonic anhydrase with a binding constant of 3 Â 10 6 M À1 and is selective over chicken-egg albumin (six histidines on the surface, K o 1 Â 10 3 M À1 ).…”

Section: Recognition Of the Surface Histidine Patternmentioning

confidence: 99%

“…4(d)), which binds carbonic anhydrase with a binding constant of 3 Â 10 6 M À1 and is selective over chicken-egg albumin (six histidines on the surface, K o 1 Â 10 3 M À1 ). 55,56 In a variation of this concept, ''two-prong'' inhibitors were designed for carbonic anhydrase in which an organic benzenesulfonamide active site inhibitor was tethered to cupric iminodiacetate through designed linkers. For example, the high-resolution crystal structure in Fig.…”

Section: Recognition Of the Surface Histidine Patternmentioning

confidence: 99%

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Targeting proteins with metal complexes

2009

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Unique properties of metal complexes, such as structural diversity, adjustable ligand exchange kinetics, fine-tuned redox activities, and distinct spectroscopic signatures, make them exciting scaffolds not only for binding to nucleic acids but increasingly also to proteins as non-traditional targets. This feature article discusses recent trends in this field. These include the use of chemically inert metal complexes as structural scaffolds for the design of enzyme inhibitors, new strategies for inducing selective coordination chemistry at the protein binding site, recent advances in the development of catalytic enzyme inhibitors, and the design of metal complexes that can inject electrons or holes into redox enzymes. A common theme in many of the discussed examples is that binding selectivity is at least in part achieved through weak interactions between the ligand sphere and the protein binding site. These examples hint to an exciting future in which "organic-like" molecular recognition principles are combined with properties that are unique to metals and thus promise to yield compounds with novel and unprecedented properties.

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Section: Recognition Of the Surface Histidine Patternmentioning

confidence: 99%

Section: Recognition Of the Surface Histidine Patternmentioning

confidence: 99%

Targeting proteins with metal complexes

2009

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“…Extending the results from small peptide model compounds, Mallik et al were able to selectively bind to peptides and proteins by recognizing unique patterns of surface-exposed histidines . The target protein was carbonic anhydrase (CA, bovine erythrocyte).…”

Section: 2 Recognition Processes In Solution321 Peptide and Protein B...mentioning

confidence: 99%

Reversible Coordinative Bonds in Molecular Recognition

2006

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“…We are interested in the recognition of peptides and proteins employing metal−ligand interactions. Various transition metal ions (e.g., Cu 2+ , Ni 2+ , Zn 2+ etc.)…”

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confidence: 99%

Surface Recognition of a Protein Using Designed Transition Metal Complexes

et al. 2001

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Each protein has a unique pattern of histidine residues on the surface. This paper describes the design, synthesis, and binding studies of transition metal complexes to target the surface histidine pattern of carbonic anhydrase (bovine erythrocyte). When the pattern of cupric ions on a complex matches the surface pattern of histidines of the protein, strong and selective binding can be achieved in aqueous buffer (pH = 7.0). The described method of protein recognition is applicable to proteins of known structures. With rapidly increasing number of solved protein structures, the method has wide applicability in purification, targeting, and sensing of proteins.

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Selective recognition of carbonic anhydrase using transition metal complexes

Cited by 10 publications

References 20 publications

Targeting proteins with metal complexes

Targeting proteins with metal complexes

Reversible Coordinative Bonds in Molecular Recognition

Surface Recognition of a Protein Using Designed Transition Metal Complexes

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