Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid–liquid interface area

Mu, Xuan; Liang, Qionglin; Hu, Ping; Ren, Kangning; Wang, Yiming; Luo, Guangsheng

doi:10.1007/s10404-009-0554-y

Cited by 39 publications

(22 citation statements)

References 37 publications

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“…To pattern cells and microenvironment, there is an iconic method in microfluidics, laminar flow patterning (LFP),31–33 which is a representative fluidic phenomenon in microfluidic channels governed by viscous force dominating over inertial force. Laminar flow of multiple streams could pattern cells,34–36 various soluble cues,37–45 as well as temperature 46.…”

Section: Cell and Microenvironment Patterningmentioning

confidence: 99%

Microfluidics for Manipulating Cells

Zheng

Sun

et al. 2012

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Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range from dynamic management of cellular interactions to high-throughput screening of cells, and to precise analysis of chemical contents in single cells. Microfluidics demonstrates a completely new perspective and an excellent practical way to manipulate cells for solving various needs in biology and medicine. This review introduces and comments on recent achievements and challenges of using microfluidics to manipulate and analyze cells. It is believed that microfluidics will assume an even greater role in the mechanistic understanding of cell biology and, eventually, in clinical applications.

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Section: Cell and Microenvironment Patterningmentioning

confidence: 99%

Microfluidics for Manipulating Cells

Zheng

Sun

et al. 2012

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“…Hydrophobic modification of one side of the microchannel was achieved by the following procedure 24 34 . First, the microchannel was submerged in Piranha solution for one hour.…”

Section: Methodsmentioning

confidence: 99%

In situ analysis of dynamic laminar flow extraction using surface-enhanced Raman spectroscopy

Wang

Qiu

et al. 2015

Sci Rep

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In this study, we performed micro-scale dynamic laminar flow extraction and site-specific in situ chloride concentration measurements. Surface-enhanced Raman spectroscopy was utilized to investigate the diffusion process of chloride ions from an oil phase to a water phase under laminar flow. In contrast to common logic, we used SERS intensity gradients of Rhodamine 6G to quantitatively calculate the concentration of chloride ions at specific positions on a microfluidic chip. By varying the fluid flow rates, we achieved different extraction times and therefore different chloride concentrations at specific positions along the microchannel. SERS spectra from the water phase were recorded at these different positions, and the spatial distribution of the SERS signals was used to map the degree of nanoparticle aggregation. The concentration of chloride ions in the channel could therefore be obtained. We conclude that this method can be used to explore the extraction behaviour and efficiency of some ions or molecules that enhance the SERS intensity in water or oil by inducing nanoparticle aggregation.

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“…In two-phase laminar flow system, it is crucial to form a stable liquid-liquid interface in the microfluidic channels [50][51][52]. To handle the continuous parallel laminar flow on the microfluidic channel, the use of surfactants or surface treatment should be considered depending on the different phase composition [53][54][55][56].…”

Section: Formation Of Parallel Laminar Flowmentioning

confidence: 99%

Microfluidic extraction using two phase laminar flow for chemical and biological applications

Huh

Jeon

Lee

et al. 2011

Korean J. Chem. Eng.

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We review the state of the art in microfluidic separation technique based two-phase laminar flow with an application focus on chemical and biological sample. As we describe herein, two-phase laminar flow in the microfluidic extraction has several biological and engineering advantages over other methods including high reproducibility, biocompatibility, and selectivity. We review advances in applications of two-phase laminar flow and examine key parameters such as flow rate, phase composition, and surface charge property, how these can affect extract performance with the technology including microfluidic separation system. A special technology focus is given to emerging novel integrative microfluidic extraction, which aims to merge aqueous phase laminar flow and electric field technologies into simple packages. We conclude with a brief discussion of some of the emerging challenges in the field and some of the approaches that are likely to enhance their application.

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Selectively modified microfluidic chip for solvent extraction of Radix Salvia Miltiorrhiza using three-phase laminar flow to provide double liquid–liquid interface area

Cited by 39 publications

References 37 publications

Microfluidics for Manipulating Cells

Microfluidics for Manipulating Cells

In situ analysis of dynamic laminar flow extraction using surface-enhanced Raman spectroscopy

Microfluidic extraction using two phase laminar flow for chemical and biological applications

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