Selenide-containing organic resonance molecules as turn-on fluorescent probes for the selective detection of hypochlorous acid

Abstract

A new series of N-P[double bond, length as m-dash]Se resonance-based fluorescent molecules were developed and used for the detection of hypochlorous acid (HClO) with rapid response and high selectivity. These Se-containing molecules can selectively detect trace amounts of HClO in nM, showing significantly strengthened fluorescence due to the enhanced resonance variation with an increased distance between the fluorophore and Se. The design of N-P[double bond, length as m-dash]Se resonance molecules in donor-resonance-acceptor (D-r-A) architectures could be an important way to develop high-performance turn-on fluorescent probes for HClO detection.

Selenium‐NMR Spectroscopy in Organic Synthesis: From Structural Characterization Toward New Investigations

“…At higher concentrations, above than the range of 10 −5 –20 −2 M, HClO is a potential health hazard to humans [164] . In 2018, Huang and co‐workers described novel selenium‐based fluorescent probes for the detection of HClO [165] . The probes were prepared in two steps, and demonstrated high sensitivity (nM) and selectivity (complex biological environment).…”

Constructing Donor-Resonance-Donor Molecules for Acceptor-Free Bipolar Organic Semiconductors

“…Owing to the inert nature of tert-butyl, the electron-withdrawing feature of P = X cannot tune it to be an acceptor as in the case of phenyl substituent [20]. These acceptor-free bipolar D-r-D molecules of t-BuPO, t-BuPS, and t-BuPSe were facilely synthesized via the direct N-P coupling followed by oxidation, sulfuration, or selenylation reaction in good total yields (45-72%, Scheme S1) [21]. Structure characterizations were established on the basis of 1 H NMR, 13 C NMR, HRMS (Figures S1-S8), elemental analysis, and single crystal analysis (Table S1).…”

In Situ Formation of Ag Nanoparticles Capped by Photoactivable Ligands for Optical Sensing of Hypochlorite

“…Therefore, the concentration level of ClO − should be controlled strictly . The development of selective and sensitive probes for ClO − detection has attracted great attention during the past decades . Traditional organic probes always have a typical structure of a reactive moiety linked to the signal unit (s), which suffer from labor‐intensive synthesis, oxygen bleaching, and organic solvent dependence .…”