Selenium and the immune response

Increased neutrophil adherence and adhesion molecule mRNA expression in endothelial cells during selenium deficiency

“…Se is known to influence critical immune cell functions and has been shown to affect antibody production, cell proliferation, cytokine production, eicosanoid metabolism, and neutrophil function [38][39][40][41][42]. However, very little is known about the influence of Se nutrition on the interaction of these cells with EC.…”

Parenteral Selenium Supplementation in Extremely Low Birth Weight Infants: Inadequate Dosage But No Correlation With Hypothyroidism

“…Selenium deficiency has been linked to a multitude of conditions such as Kashin cardiomyopathy, Kashin-Beck osteoartropathy, systemic immune response syndrome and sepsis in adults, and chronic lung disease and hemolytic anemia in preterm infants. [1][2][3][4][5][6][7] Selenium as selenocysteine is a component of the metalloenzymes that are present in many body tissues, including glutathione peroxidase (GSHPx) and iodothyronine deiodinase type I. [7][8][9] GSHPx serves as an antioxidant, which protects cells from free radical damage.…”

Feeding different levels of vitamin E and selenium has no effect on serum immunoglobulin Y (IgY) production by layers vaccinated against Escherichia coli and avian encephalomyelitis virus

“…Experiments on the immunological effects of Se supplementation suggested that IgM and IgG antibody responses could be boosted most effectively by concentrations considerably in excess of those required for normal growth, but other work has shown that such results depend on species, age, sex and antigen (TURNER & FINCH, 1991). HEGAZY & ADACHI (2000) found better immune response against Salmonella typhimurium infection when 1 ppm of Se was supplemented on the diet.…”