Selenium plasma levels in hemodialysis patients: Comparison between North and Southeast of Brazil

Stockler‐Pinto, Milena Barcza; Malm, Olaf; Azevedo, Suellen Regina Geraldo; Farage, Najla Elias; Cozzolino, Sílvia Maria Franciscato; Mafra, Denise

doi:10.5935/0101-2800.20140070

Cited by 9 publications

(7 citation statements)

References 34 publications

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“…Only 2.3% of HD patients had hyposeleniemia. Inconsistent with our findings, a study in Brazil found that all HD patients have Se deficiency [16]. The difference between the two studies may be related to differences in dietary intake of Se and Se concentration in soil.…”

Section: Discussioncontrasting

confidence: 50%

Evaluation of Plasma Selenium Level and its Association with Malnutrition in Hemodialysis Patients in Golestan Province, Iran

Amirkhanlou¹,

Emadi²,

Rashedi³

et al. 2017

jcbr

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Introduction: Selenium (Se) is a rare element with well-demonstrated anti-oxidative effects that acts as an enzyme co-factor in physiological interactions. Low plasma Se level and malnutrition in hemodialysis (HD) patients could increase the risk of morbidity and mortality among these patients. Moreover, Se deficiency leads to oxidative stress and inflammatory response. Therefore, this study aimed to determine the association of plasma Se levels with malnutrition and inflammatory markers in HD patients. Materials and Methods: This cross-sectional study included 88 patients undergoing routine HD at dialysis unit of 5 th Azar Hospital in Gorgan, northeastern Iran. In addition, 88 healthy individuals were selected from the patients' families as controls. Level of Se, C-reactive protein (CRP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG) and albumin were measured in the patients and controls by the atomic absorption method. Se levels were categorized into two groups of "over half-normalized" and "under half-normalized" for further analysis. Results: Hyposeleniemia was found in two patients (2.3%). The mean level of Se in HD patients was lower than in the healthy controls (P< 0.001). Among all HD subjects, 30.3% had under half-normalized Se level. In addition, 79.5% of HD patients were well nourished and 20.5% were moderately malnourished. There was no statistically significant difference between the mean level of Se in the malnourished and well-nourished subjects. Total mean level of HDL, LDL, TG and CRP had not significant correlation with plasma Se levels. There was a significant positive correlation between the mean plasma albumin and Se levels in the HD patients (P<0.05). Conclusions: The mean plasma Se level of HD patients in this area is in the normal range. There is no association between plasma Se level and malnutrition. Based on our findings, hyposelenemia is not a problem in HD patients in the Golestan Province.

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Section: Discussioncontrasting

confidence: 50%

Evaluation of Plasma Selenium Level and its Association with Malnutrition in Hemodialysis Patients in Golestan Province, Iran

Amirkhanlou¹,

Emadi²,

Rashedi³

et al. 2017

jcbr

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“…[31][32][33] Although the reason for reduced erythrocyte and plasma Se levels in CRF patients is not completely explained, reduced dietary intake, impaired intestinal absorption, increased urinary loses and abnormal binding to Se transport proteins could be responsible for this phenomenon. 34,35 Decreased protein intake has been proposed as a significant cause of Se insufficiency, as protein foodstuffs contain the largest amount of Se. 9 The current investigation showed a significant decrease in plasma GPx activity in CRF patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

The association of oxidant–antioxidant status in patients with chronic renal failure

Aziz¹,

Majeed²,

Diab

et al. 2015

Renal Failure

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Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements [selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), vitamins E and C. The obtained values were compared with 42 age-and sex-matched healthy controls. There were significantly lower mean values of plasma Se, GPx, vitamins E and C, erythrocyte Se, SOD and CAT levels in the patient group compared to the control group (p50.001). Plasma MDA showed a significant increase in all CRF patients in comparison with controls. No significant difference was found in plasma Cu, Zn, and erythrocyte GPx, Cu and Zn levels between patient and control groups. These findings indicate oxidative stress is present in patients of CRF, and may serve to establish a simple protocol for evaluation of renal function.

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“…The low natural levels of Se in soils and its absence in fertilization to crops explain the low contents in food from vegetables [12] and consequently in Brazilian diet, except for northern areas [2]. Although, in a study of hemodialysis patients from north and southeast of Brazil, both patient groups presented low Se plasma levels when compared to recommended values; independently of the region, all patients presented Se deficiency [13].…”

Section: Selenium Fertilization In Tropical Weathered Soilsmentioning

confidence: 99%

“…According to the Selenium-Tellurium Development Association, the best way for Se application is along with other nutrients [15]. There are positive effects in Se application along with phosphorus fertilization [13].…”

Section: Selenium Fertilization In Tropical Weathered Soilsmentioning

confidence: 99%

“…Grazing Se fertilizer has been shown to be more effective and safe treatment than animal dosing [13]. Selenium intake by ruminants in organic form, especially as selenoamino acids, needs to be release from proteins until through inorganic forms to be metabolized while Se in milk is from organic Se supply or converted by ruminal microorganisms [29].…”

Section: Selenium Fertilization For Tropical Grazingmentioning

confidence: 99%

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Selenium Fertilization in Tropical Pastures

Faria¹,

Luz²,

Abdalla³

2020

Importance of Selenium in the Environment and Human Health

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Brazil is one of the largest meat producers. Meat along with other animal products have been responsible for its larger contribution as source of selenium (Se) for human. However, Se deficiency remains a concern because researches have indicated that this nutrient is found in low levels in Brazilian diet. Cattle in Brazil are fed basically from pasture, but there are strong evidences that soils contain low availability of Se; consequently plants and animals incorporate low Se levels. Pastures, Se fertilized, bring benefits to nutrition and health of animal consequently to humans already known in some countries. In contrast, Se fertilization on tropical weathered soils and tropical forages is little known. However, Se management as fertilizer in tropical environments requires researches involving field experiments, especially with animals, for establishing of safe and effective Se recommendations as fertilizer due to the Se toxicity potential and complexity in system of soil-plant-animal-human.

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Selenium plasma levels in hemodialysis patients: Comparison between North and Southeast of Brazil

Abstract: We concluded that patients from North (Amazon) region present higher plasma Se levels when compared to the patients from Southeast of Brazil. However, independently of the region, HD patients presented Se deficiency.

Cited by 9 publications

References 34 publications

Evaluation of Plasma Selenium Level and its Association with Malnutrition in Hemodialysis Patients in Golestan Province, Iran

Evaluation of Plasma Selenium Level and its Association with Malnutrition in Hemodialysis Patients in Golestan Province, Iran

The association of oxidant–antioxidant status in patients with chronic renal failure

Selenium Fertilization in Tropical Pastures

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