Selenium Reduces Enterohemorrhagic
            <i>Escherichia Coli</i>
            O157:H7 Verotoxin Production and Globotriaosylceramide Receptor Expression on Host Cells

Surendran-Nair, Meera; Johny, Anup Kollanoor; Ananda-Baskaran, Sangeetha; Norris, Carol; Lee, Ji Young; Venkitanarayanan, Kumar

doi:10.2217/fmb.16.16

Cited by 10 publications

(5 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is increasing interest in the use of natural compounds as antibiotic alternatives against foodborne pathogens [ 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 ]. Essential oils are volatile aromatic compounds obtained from different plant parts and are effective against foodborne pathogens, including Salmonella , in vivo and in vitro [ 133 , 134 , 135 , 139 , 140 , 141 , 142 , 143 , 144 ].…”

Section: Antibiotic Alternatives Against Salmonellamentioning

confidence: 99%

Antibiotic-Resistant Salmonella in the Food Supply and the Potential Role of Antibiotic Alternatives for Control

Nair

Venkitanarayanan

Johny

2018

Foods

Self Cite

212

View full text Add to dashboard Cite

Salmonella enterica is one of the most ubiquitous enteropathogenic bacterial species on earth, and comprises more than 2500 serovars. Widely known for causing non-typhoidal foodborne infections (95%), and enteric (typhoid) fever in humans, Salmonella colonizes almost all warm- and cold-blooded animals, in addition to its extra-animal environmental strongholds. The last few decades have witnessed the emergence of highly virulent and antibiotic-resistant Salmonella, causing greater morbidity and mortality in humans. The emergence of several Salmonella serotypes resistant to multiple antibiotics in food animals underscores a significant food safety hazard. In this review, we discuss the various antibiotic-resistant Salmonella serotypes in food animals and the food supply, factors that contributed to their emergence, their antibiotic resistance mechanisms, the public health implications of their spread through the food supply, and the potential antibiotic alternatives for controlling them.

show abstract

Section: Antibiotic Alternatives Against Salmonellamentioning

confidence: 99%

Antibiotic-Resistant Salmonella in the Food Supply and the Potential Role of Antibiotic Alternatives for Control

Nair

Venkitanarayanan

Johny

2018

Foods

Self Cite

212

View full text Add to dashboard Cite

show abstract

“…Then the bacterial culture in PBS was serially diluted (1:10) to get a final concentration of 10 7 CFU ml −1 . From this, 100 μl was used in the experiments to inoculate the wells containing 2 ml TSB ( Amalaradjou et al, 2010 ; Surendran Nair et al, 2016a , b ).…”

Section: Methodsmentioning

confidence: 99%

Characterizing the Antimicrobial Function of a Dairy-Originated Probiotic, Propionibacterium freudenreichii, Against Multidrug-Resistant Salmonella enterica Serovar Heidelberg in Turkey Poults

Nair

Johny

2018

Front. Microbiol.

View full text Add to dashboard Cite

Antimicrobial potential of a dairy-origin probiotic bacteria, Propionibacterium freudenreichii, against multidrug-resistant Salmonella Heidelberg (SH) in turkey poults was determined in the current study. Employing in vitro experiments, two strains (subsp.) of P. freudenreichii: P. freudenreichii freudenreichii B3523 (PF) and P. freudenreichii shermanii B4327 (PS) were tested for their ability to resist low pH (2.5) and bile salts (0.3%). In addition, the ability of the strains to adhere to and invade avian epithelial cells was determined after exposure to Propionibacterium strains followed by SH challenge. Moreover, the antibacterial activity of the strains’ cell-free culture supernatants (CFCSs) were tested against three major foodborne pathogens, including SH. Furthermore, the susceptibility of the strains to common antibiotics used for human therapy was determined. The hemolytic properties of the strains were determined in comparison to Streptococcus pyogenes, a known hemolysis-causing pathogen. Appropriate controls were kept in all studies. Using two in vivo experiments, PF was tested against SH colonization of poult ceca and dissemination to liver and spleen. The four treatment groups were: negative control, PF control (PFC), SH control (SC), and a test group (PFS; PF + SH). The poults in the PFC and PFS groups were inoculated with 1010 CFU ml−1 PF on day 1 through crop gavage and subsequently supplemented through drinking water. On day 7, SC and PFS groups were challenged with SH at 106 CFU ml−1, and after 7 days, cecum, liver, and spleen were collected for determining surviving SH populations. Results indicated that both PF and PS resisted pH = 2.5 and 0.3% bile salts with surviving populations comparable to the control and adhered well onto the avian epithelial cell lines. The strains were susceptible to antibiotics and did not invade the epithelial cells or exhibit hemolytic properties. The CFCSs were highly bactericidal against all tested pathogens. In turkey poults, PF significantly reduced cecal colonization of SH and the dissemination of the pathogen to the liver, compared to the SH challenge controls (P < 0.05). Results revealed that PF, a non-host gastrointestinal tract-derived probiotic, could be an antibiotic alternative to prevent the early colonization of SH in poults, improving the preharvest safety of turkeys.

show abstract

“…What all E. coli strains associated with HUS appear to share is the capacity to produce verotoxins and the ability to adhere to and colonize the human intestines. Since verotoxin genes can be transferred between bacteria, it is possible that additional E. coli pathotypes linked to HUS could be discovered in the future [69]. According to Yamasaki et al [70], in Japan, the quantitative detection of shiga toxins directly from stool specimens of patients played a crucial role in identifying an outbreak of EHEC.…”

Section: Epidemiology Of Enterohemorrhagic E Coli (Ehec)mentioning

confidence: 99%

Pathogenic E. coli in the Food Chain across the Arab Countries: A Descriptive Review

Mohamed,

Habib

2023

Foods

View full text Add to dashboard Cite

Foodborne bacterial infections caused by pathogens are a widespread problem in the Middle East, leading to significant economic losses and negative impacts on public health. This review aims to offer insights into the recent literature regarding the occurrence of harmful E. coli bacteria in the food supply of Arab countries. Additionally, it aims to summarize existing information on health issues and the state of resistance to antibiotics. The reviewed evidence highlights a lack of a comprehensive understanding of the extent to which harmful E. coli genes are present in the food supply of Arab countries. Efforts to identify the source of harmful E. coli in the Arab world through molecular characterization are limited. The Gulf Cooperation Council (GCC) countries have conducted few surveys specifically targeting harmful E. coli in the food supply. Despite having qualitative data that indicate the presence or absence of harmful E. coli, there is a noticeable absence of quantitative data regarding the actual numbers of harmful E. coli in chicken meat supplies across all Arab countries. While reports about harmful E. coli in animal-derived foods are common, especially in North African Arab countries, the literature emphasized in this review underscores the ongoing challenge that harmful E. coli pose to food safety and public health in Arab countries.

show abstract

Selenium Reduces Enterohemorrhagic Escherichia Coli O157:H7 Verotoxin Production and Globotriaosylceramide Receptor Expression on Host Cells

Cited by 10 publications

References 57 publications

Antibiotic-Resistant Salmonella in the Food Supply and the Potential Role of Antibiotic Alternatives for Control

Antibiotic-Resistant Salmonella in the Food Supply and the Potential Role of Antibiotic Alternatives for Control

Characterizing the Antimicrobial Function of a Dairy-Originated Probiotic, Propionibacterium freudenreichii, Against Multidrug-Resistant Salmonella enterica Serovar Heidelberg in Turkey Poults

Pathogenic E. coli in the Food Chain across the Arab Countries: A Descriptive Review

Contact Info

Product

Resources

About