Selenium supplementation shows protective effects against patulin-induced brain damage in mice via increases in GSH-related enzyme activity and expression

Song, Erqun; Su, Chuanyang; Fu, Juanli; Xia, Xiaomin; Yang, Siyu; Xiao, Congxue; Lü, Bin; Chen, Hongjun; Sun, Zhiyin; Wu, Shanmei; Song, Yang

doi:10.1016/j.lfs.2014.05.022

Cited by 57 publications

(38 citation statements)

References 44 publications

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“…However, in general, for nonclinical studies, efficacy and safety pharmacological studies are performed keeping in mind target organ toxicities, dose selection, and known lethal dose. Mercury is most toxic of all the heavy metals [22,[38][39][40][41][42][43] and is known to induce toxicity in the cardio respiratory system, reproduction system, kidneys, liver, brain, and lungs [3,[44][45][46]. Humans are exposed to these metals from numerous sources, including contaminated air, water, soil, and food.…”

Section: Discussionmentioning

confidence: 99%

“…Se has the ability to counteract free radicals and protects the structure and function of proteins, DNA, and chromosomes against the injury of oxidation [20]. Several studies reported that selenium protects against the toxicity of heavy metals [4,[21][22][23][24][25][26][27][28][29]. Se can effectively counteract oxidative damage toxic agents caused by scavenging reactive oxygen radicals and protect membrane integrity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Ansar

2015

Biol Trace Elem Res

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Selenium is an essential cofactor in the key enzymes involved in cellular antioxidant defense. This study was designed to investigate the protective effects of selenium on mercury chloride (HgCl2)-induced toxicity. Male Wistar rats were randomly divided into four groups of six animals each. The first group was control; the second group was treated with mercuric chloride (HgCl2: 50 mg/kg/bw). The third group was treated with sodium selenite (Se 0.2 mg/kg/bw), and the fourth group received Se (0.2 mg/kg/bw) plus HgCl2 (50 mg/kg for 24 h). The influence of Se on mercury induced levels of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) and zinc, copper, and iron in serum of rats were observed. The serum MDA, SOD, zinc, and iron concentrations were found to be statistically different among the control and toxin-treated group. The serum levels of IL-6, IL-10, and TNF-α were also measured. There was a significant decrease in the levels of TNF-α, IL-6, and IL-10 in toxin-treated group II compared with that of the control group (p < 0.05). A significant increase in the serum levels of inflammatory cytokines IL-6, TNF-α, and IL-10 after administration of Se seemed to counteract some of the damage, as indicated by differences in the serum concentrations of major elements.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Ansar

2015

Biol Trace Elem Res

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“…21 The research more and more often includes selenoorganic compounds -either naturally occurring forms or newly synthesized substances, e.g., selenomethionine, naphthalimide-based selenocyanates, 2-(5-selenocyanatopentyl)-benzo[de]isoquinoline-1,3-dione, diphenyl diselenide, selenofuranoside, p-methoxyldiphenyl diselenide, selenocyanates, and diphenylmethyl selenocyanate. [4][5][6]9,16,17,19,20,[22][23][24][25][26] The results regarding the comparison of inorganic and organic compounds are not fully consistent, although the newest studies usually reveal plasma urea and plasma creatinine ↑; kidney vitamin C, GSH, GST, GPx, GR, CAT, δ-ALA-D ↓ p-methoxyl-diphenyl diselenide 50 mg/kg or 100 mg/kg, orally 6 days lower dose: plasma urea (±); plasma creatinine (0); kidney GSH, GST, GPx, GR, δ-ALA-D (±); kidney vitamin C, CAT (+) higher dose: plasma urea and plasma creatinine (±), kidney GSH, GST, GPx, GR, vitamin C, CAT (+) kidney δ-ALA-D (±) none ↓ -decrease; ↑ -increase; (+) -full protection; (±) -partial protection; (0) -lack of protection; GST -glutathione S-transferase; GPx -glutathione peroxidase; CAT -catalase; SOD -superoxide dismutase; GSH -reduced glutathione; TBARS -thiobarbituric acid-reactive substances; GR -glutathione reductase; δ-ALA-D -δ-aminolevulinic dehydratase..…”

Section: Comparison Of the Effect Of Different Selenium Forms On Orgamentioning

confidence: 99%

Selenium – a fascinating antioxidant of protective properties

Kiełczykowska¹,

Kocot²,

Paździor³

et al. 2018

Adv Clin Exp Med

181

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Selenium is a trace element which fulfils important functions in the organism. Its deficit may cause acute disorders, but an overdose can also lead to severe consequences. The functions of selenium in the organism are mainly connected with its antioxidant properties, as it is an essential part of important antioxidant enzymes. Disturbances of oxidant balance have been found to be involved in the activity of numerous harmful factors as well as in the pathogenesis of diverse illnesses. Selenium administration has proved to be effective against the toxicity of many agents and the side effects of drugs. However, the narrow range between therapeutic and toxic doses of selenium, as well as the dependence of its effect on the applied form, dose and method of treatment, makes the choice of the most effective supplement a very complex issue. Divergent forms of selenium are still being studied, including both inorganic and organic compounds as well as Se-enriched natural products. The newest research has also involved selenium nanoparticles. The aim of this review is to present the great potential of selenium for protecting the organism against a wide variety of environmental pollutants, drugs and physical factors.

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“…In animal studies, patulin administration causes damage to different organs including brain, kidney, liver (de Melo et al 2012;Song et al 2014;Boussabbeh et al 2015), thymus (Arzu Koçkaya et al 2009), and skin (Saxena et al 2009). Despite several negative effects of patulin observed in animal tissues, the molecular mechanism of toxicity is still not fully known.…”

Section: Introductionmentioning

confidence: 99%

Developments in the Monitoring of Patulin in Fruits Using Liquid Chromatography: an Overview

2018

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Patulin is a mycotoxin that exhibits a number of toxic effects in animals. The main sources of patulin intake in human diet that was shown for EU consumers are apple juice and nectar and for this reason, apple-based food is most often monitored for this mycotoxin. However, the presence of patulin in other fruits, including stone fruits, and soft fruits has been reported as well. Most of them are seasonal, suitable for consumption for short time, and are usually processed in order to be commercially available throughout the year. Patulin can also be generated during food storage and remains stable over food processing procedures. Therefore, constant monitoring of different fruit-based products ought to be carried out to provide proper estimation of human exposure to this toxin. The preferred approach used for mycotoxin determination in a variety of foods is liquid chromatography (LC) allowing quantitative analysis of patulin content. This paper presents recently proposed LC methods with ultraviolet and mass spectrometric detection for patulin quantification in fruits and derived products. We focus on developments in sample preparation and the applied analytical conditions.

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Selenium supplementation shows protective effects against patulin-induced brain damage in mice via increases in GSH-related enzyme activity and expression

Cited by 57 publications

References 44 publications

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Effect of Selenium on the Levels of Cytokines and Trace Elements in Toxin-Mediated Oxidative Stress in Male Rats

Selenium – a fascinating antioxidant of protective properties

Developments in the Monitoring of Patulin in Fruits Using Liquid Chromatography: an Overview

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