Selenium suppresses the activation of transcription factor NF-κB and IRF3 induced by TLR3 or TLR4 agonists

Youn, Hyung‐Sun; Lim, Hyo Jin; Choi, Youngin; Lee, Joo Young; Lee, Mi-Young; Ryu, Jae‐Ha

doi:10.1016/j.intimp.2007.12.008

Cited by 62 publications

(42 citation statements)

References 28 publications

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“…Both Ca 2 + flux and ROS feed into NFjB activation, and Se supplementation of macrophages to above-adequate levels may be particularly disruptive for the redox balance that regulates NFjB signaling. For example, experiments involving RAW 264.7 mouse macrophages and an NFjB reporter system demonstrated that higher Se status in these cells inhibited NFjB activation induced by LPS (277). Expression of cyclooxygenase-2 (Cox-2) and inducible nitric oxide synthase (iNos), both of which depend on NFjB activation, were also decreased with Se supplementation during activation through either Toll-like receptor 3 (Tlr3) or Tlr4 using poly(i:c) or LPS, respectively.…”

Section: The Effects Of Se Intake On Camentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

715

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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Section: The Effects Of Se Intake On Camentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

715

496

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“…The expression and production of TSLP was controlled by NF-jB in mast cells . Youn et al (2008) reported that Se suppresses LPS-induced NF-jB activation in RAW 264.7 cells. In addition, Se inhibited LPS-induced nuclear translocation of NF-jB in murine macrophage cells, J774A.1 cells (Kim et al 2004).…”

Section: Discussionmentioning

confidence: 99%

The suppression of thymic stromal lymphopoietin expression by selenium

Moon

Kim

2011

Amino Acids

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Thymic stromal lymphopoietin (TSLP) is a key mediator of allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis. Selenium (Se) has various effects such as antioxidant, antitumor, antiulcer, and anti-inflammatory effects. However, the effect of Se on the production of TSLP has not been clarified. Thus, we investigated how Se inhibits the production of TSLP in the human mast cell line, HMC-1 cells. Se suppressed the production and mRNA expression of TSLP in HMC-1 cells. The maximal inhibition rate of TSLP production by Se (10 μM) was 59.14 ± 1.10%. In addition, Se suppressed the nuclear factor-κB luciferase activity induced by phorbol myristate acetate plus A23187. In the activated HMC-1 cells, the activation of caspase-1 was increased; whereas the activation of caspase-1 was decreased by pretreatment with Se. These results suggest that Se can be used to treat inflammatory and atopic diseases through the suppression of TSLP.

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“…Attempts to enhance gastrointestinal development and protect against infection and necrotizing enterocolitis have included use of prebiotics and probiotics, which bolster development of the microbiota. A recent study showed that although enteral supplementation with a prebiotic mixture of neutral and Protein calorie malnutrition, dietary deficiency (Moynahan, 1974;Stevens and Lubitz, 1998), high phytate (Moynahan, 1974;Stevens and Lubitz, 1998), transport deficiency (Moynahan, 1974;Stevens and Lubitz, 1998) Supplementation in infection (Stafford et al, 2013) Prenatal maternal supplement (Shah and Sachdev, 2006;Wieringa et al, 2010) Maternal supplementation (Terrin et al, 2013) Infant supplementation (Osendarp et al, 2007;Osendarp et al, 2006) Thymic atrophy, lymphopenia altered T-cell subsets, (Youn et al, 2008;Smith et al, 2008) Humans (Chen, 2012) HIV-1 infection (Shah and Sachdev, 2006;Wieringa et al, 2010;Smith et al, 2008) ↑Microbial diversity, composition, & colonization (Kasaikina et al, 2011) Required for glutathione peroxidase activity ↓NF-κB activity, enhanced virulence of coxsackie B virus Deficiency in HIV-1 linked to progression, antiretroviral therapy increased levels acidic oligosaccharides did increase early postnatal intestinal colonization with a trend toward increased bifidobacteria, extensive use of broad-spectrum antibiotics counteracted the growth of all intestinal microbiota and delayed normal microbiota development (Westerbeek et al, 2013).…”

Section: Influence Of Nutrients In Priming and Development Of The Gasmentioning

confidence: 99%

“…Selenoproteins are an important component of the antioxidant host defense system, affecting leukocyte and natural killer (NK) cell function and inhibiting NF-κB activation by some agonists including LPS (Youn et al, 2008). Deficiencies in micronutrients, including copper, selenium, and vitamin E, may be associated with increased oxidative stress, altered immune function, and greater virulence of both amyocarditic and myocarditic strains of coxsackievirus B3 (CVB3), leading to increased pathology that has been attributed to increased viral load in the case of copper or changes in the viral genome in selenium and vitamin E deficiency (Smith et al, 2008).…”

Section: Malnutrition Nutrient Deficiency and Infectionmentioning

confidence: 99%