Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide

Qin, Tao; Jin, Cheqing; Wang, Deyun; Hu, Yuanliang; Zhang, Jing; Wang, Mi; Qiu, Shulei; Gao, Zhenzhen; Liu, Rongrong; Yu, Yun; Huang, Yee; Wang, Qiaochu; Wang, Qiaoxiu

doi:10.1016/j.carbpol.2013.02.072

Cited by 52 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The serum antibody titers in sGPS 5 and sGPS 6 groups at all time points were significantly higher than those in unmodified GPS group at same time points, and in sGPS 6 group on D 14 –D 21 was the highest, these results indicated that selenylation modification could significantly enhance the humoral immune-enhancing activity of GPS, sGPS 6 possessed the best efficacy. Our previous research results also confirmed that selenylation modification can significantly enhance the immune-enhancing activity of CAP [36].…”

Section: Discussionsupporting

confidence: 80%

Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide

et al. 2014

Self Cite

View full text Add to dashboard Cite

The garlic polysaccharide was modified by HNO3-Na2SeO3 method according to orthogonal design L9(34) to obtain nine selenizing garlic polysaccharides, sGPS1-sGPS9. Their effects on chicken peripheral lymphocytes proliferation in vitro were compared by MTT assay. The results showed that sGPSs could significantly promote lymphocytes proliferation, sGPS3, sGPS5 and sGPS6 presented stronger efficacy. In vivo experiment, 14-day-old chickens were injected respectively with sGPS3, sGPS5 and sGPS6 when they were vaccinated with ND vaccine taking unmodified GPS as control. The results showed that three sGPSs could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-γ and IL-2 contents. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of GPS, sGPS6 possessed the best efficacy and could be as a candidate drug of immunoenhancer. Its optimal modification conditions were 400 mg of sodium selenite for 500 mg of GPS, reaction temperature of 70°C and reaction time of 6 h.

show abstract

Section: Discussionsupporting

confidence: 80%

Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Thus, increasing the absorption of dietary selenium by the human body could assist the proliferation of lymphocytes, which induces or promotes lymphocyte interferon, IL‐2, and other soluble immune‐active compounds. However, inorganic selenium compounds when accumulated are toxic and mutagenic, and it is usually difficult to control the dose of selenium in the diet (Qin and others ). On the contrary, organic selenium compounds treated by a methylation detoxification process have low toxicity and few side effects, but significant immune response and strong anticancer activity.…”

Section: Major Methods Of Molecular Modification Of Polysaccharidesmentioning

confidence: 99%

Molecular Modification of Polysaccharides and Resulting Bioactivities

Xiong

Lai

et al. 2015

Comp Rev Food Sci Food Safe

410

172

View full text Add to dashboard Cite

Polysaccharides are ideal natural resources for supplements and pharmaceuticals that have received more and more attention over the years. Natural polysaccharides have been shown to have fewer side effects, but because of their inherently physicochemical properties, their bioactivities were difficult to compare with those of synthetic drugs. Thus, researchers have modified the structures and properties of natural polysaccharides based on structure-activity relationships and have obtained better functionally improved polysaccharides. This review focuses on the major modification methods of polysaccharides, and discusses the effect of molecular modification on their physicochemical properties and bioactivities. Molecular modification methods mainly include chemical, physical, and biological changes. Chemical modification is the most widely used method; it can significantly increase the water solubility and bioactivities of polysaccharides by grafting onto other groups. Physical and biological modifications only change the molecular weight of a polysaccharide, and thereby change its physicochemical properties and bioactivities. Most of the molecular modifications bring about an increase in the antioxidant activity of polysaccharides, and among these, sulfated and acetylated modifications are very common. Furthermore, phosphorylation modification is the most common application to increase antitumor activity, and modified polysaccharides have been shown to have anti-HIV activity as the result of sulfated modification.

show abstract

“…The reasons may be that the selenylation modification is a widely used method to enhance the biological activities, especially in antioxidant and immune enhancement [18,19]. Many other researchers also proved that the efficacy of polysaccharides by reforming their structure was significantly better than nonreformed drugs [20].…”

Section: Changes Of Serum Tnf-α and Il-6 Concentrations In The Cy-trementioning

confidence: 99%

Effects of Selenizing Codonopsis pilosula Polysaccharide on Macrophage Modulatory Activities

Qin¹,

Ren²,

Lin³

et al. 2016

Journal of Microbiology and Biotechnology

Self Cite

View full text Add to dashboard Cite

The purpose of the present study was to investigate the immune-enhancing activity of selenizing Codonopsis pilosula polysaccharide (sCPPS5) in nonspecific immune response. In in vitro experiment, the results showed that sCPPS5 could promote the phagocytic uptake, NO production, and TNF-α and IL-6 secretion of RAW264.7 cells. sCPPS5 could also strongly increase the IκB-α degradation in the cytosol and the translocation of NF-κB p65 subunit into the nucleus of RAW264.7 cells. In the vivo experiment, sCPPS5 at medium doses could significantly improve the phagocytic index of peritoneal macrophages and induce the secretion of TNF-α and IL-6. Moreover, the effect of sCPPS5 was significantly better than Codonopsis pilosula polysaccharide (CPPS). These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CPPS in the nonspecific immune response.

show abstract

Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide

Cited by 52 publications

References 19 publications

Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide

Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide

Molecular Modification of Polysaccharides and Resulting Bioactivities

Effects of Selenizing Codonopsis pilosula Polysaccharide on Macrophage Modulatory Activities

Contact Info

Product

Resources

About