Self assembled monolayer based liquid crystal biosensor for free cholesterol detection

Tyagi, M S; Chandran, Achu; Joshi, Tilak; Prakash, Jai; Agrawal, Ved Varun; Biradar, A. M.

doi:10.1063/1.4871704

Cited by 46 publications

(17 citation statements)

References 30 publications

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“…Introducing nanoparticles (metallic and non-metallic) in NLCs has created a targeted source of detection for certain biomolecules/viruses [ 46 , 48 , 51 , 52 ]. Nanomaterials like gold, silver, CdS, carbon nanotubes, quantum dots, etc.…”

Section: Introductionmentioning

confidence: 99%

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Choudhary

George

2018

Biosensors

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The established role of nematic liquid crystals (NLCs) in the recent rapid development of displays has motivated researchers to modulate the electro-optical properties of LCs. Furthermore, adding nanomaterials into NLCs has led to enhancements of the properties of NLCs, like reduced threshold of the operating voltage, variation in pretilt angle, reduced switching time, etc. These enhanced properties, due to interfacial dynamics, are enabling wider applications of NLCs and nanomaterials. The recent literature of nanomaterial-doped NLCs is rich with various kinds of nanomaterials in a variety of NLCs. The light has been focused on the most widely used and studied gold nanoparticles in NLCs. The intrinsic inherent property of easy excitation of surface plasmons polaritons (SPP) is the mediating interaction of NLC electric dipoles and the polarization of charges in the GNP surface. The concepts and methods for the application of metal nanomaterials as dopants in NLCs are discussed for future applications, especially biosensors. The biosensing application of NLCs alone has already been proven in the literature. However, it is always desirable to further enhance the detection efficiency and selectivity, which have been achieved by the conjugation of GNPs and nickel nanoparticles with NLCs and their compatibility with biological materials. This aspect of future application of nanoparticles and NLC makes the point more selective to be included in the present manuscript.

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Section: Introductionmentioning

confidence: 99%

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Choudhary

George

2018

Biosensors

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“…Despite their enormous success in display devices, there are several applications of LC in another arena like biology (as the combination of order and mobility is a basic requirement for structure formation in a living system) biomedicines, analytical chemistry and nanophysics [4][5][6][7]. The impact of LC on modern technology such as a biosensor, memory devices, LC-based lasers, holography has been profound [8,9]. Besides these modern familiar applications, there are other devices with improved properties of LC by doping nanoparticles or mixing with other inorganic/organic solvents as LCs are favorable material for the effective transfer of ions and electrons [6,[10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Nematic liquid crystal/dimethylsulphoxide mixture based tuning condenser

2020

Self Cite

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Here, we demonstrate experimentally the existence oftemporally variable dielectric behavior of a nematic liquid crystal (NLC), the most widely used liquid crystal (LC) phase among all LCs materials, by mixing dimethylsulphoxide (DMSO) into former. The intermolecular interactions and nanosegregation of the molecular LC structures have influenced their self-assembly by mixing DMSO into it. We mainly examined the dielectric parameters such as dielectric permittivity, dielectric loss factor, and absorption/energy dissipation and observed that the NLC/DMSO mixture shows a nearly dielectric-conductor (D-C) transition as time passes. The presence of DMSO in this analysis was confirmed by Fourier transform infrared spectroscopy while time-dependent dielectric studies were carried out using dielectric spectroscopic techniques. The promising idea of showing D-C transition is truly proven that may open the possibilities for real-time variable and supercapacitors.

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“…These coupled mechanisms result in a unique system for the detection or measurement of chemicals in solution. Several recent papers have already demonstrated the high sensitivity of liquid crystal-water interfaces in either planar or droplet geometries 3 , for the detection of agents such as bacterial endotoxin 4,5 , electrolytes 6 , cholesterol 7,8 , and for label-free monitoring of biomolecular interactions 9 .…”

Section: Introductionmentioning

confidence: 99%

X-ray reflectivity reveals ionic structure at liquid crystal–aqueous interfaces

Hallett¹,

Hayward

Arnold

et al. 2017

Soft Matter

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Here X-ray reflectivity has been used to determine the structure of liquid crystal monolayers for different cyanobiphenyl homologues supported on aqueous solutions of two different salt species. Sodium iodide induces homeotropic ordering for all of the monolayer forming liquid crystal homologues studied here, and forms a Stern layer of iodide ions at the liquid crystal cyano headgroup, similar to the case of lipids or surfactants supported on electrolyte solutions. The liquid crystal headgroups were also found to penetrate into the water surface when binding with iodide ions. Sodium bromide, however, does not form the same localisation of ions close to a liquid crystal monolayer, and instead appears to produce no noticeable change in the scattering length density of the liquid crystal monolayer compared to pure water. However, on further compression the X-ray reflectivity dramatically changes, revealing the emergence of the so-called "trilayer" structure for 5CB and 8CB. This transition occurs at a lower areal density for sodium bromide than for pure water, and unlike for the uncompressed film, a layer of bromide ions was found at the trilayer-water interface.

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Self assembled monolayer based liquid crystal biosensor for free cholesterol detection

Cited by 46 publications

References 30 publications

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Conjugation of Nanomaterials and Nematic Liquid Crystals for Futuristic Applications and Biosensors

Nematic liquid crystal/dimethylsulphoxide mixture based tuning condenser

X-ray reflectivity reveals ionic structure at liquid crystal–aqueous interfaces

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