Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release

Wu, Qing-Xi; Wang, Dandan; Su, Ting; Cheng, Xiao-Du; Xu, Xin; Chen, Yan

doi:10.1007/s10570-017-1454-z

Cited by 21 publications

(7 citation statements)

References 61 publications

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“…[39] Thus, the above designed carriers demonstrated an improvement in drug loading as a result of drug conjugation to the BC polymer with various binding sites. The drug loading percentage of calcium alginate/sodium cellulose sulfate microcapsule for BSA was 38.14 %, [40] Ketamin@PEGÀ PLGA was 39.1 % [41] and that of, paclitaxel@BSA nanoparticles was 27.1 % [39] which is comparable with the results of this study. Additionally, encapsulation efficiency values were higher than those of folic acid-loaded chitosan nanoparticles and cellulose nanocrystals (62 %), [42] zidovudine-loaded in a carboxy methyl cellulose and compritolÀ PEG carrier (18 %), [43] and this was in the range of paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) nanoparticles.…”

Section: Determination Of %Dl and %Eesupporting

confidence: 90%

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Preparation and Characterization of 5‐Fluorouracil Loaded Cellulose and Exosome Nanocarriers: Sustained Release Behavior and Cytotoxicity Studies**

et al. 2023

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In recent years, much effort has been devoted to designing nanoparticle drug delivery systems and improving the efficacy of anticancer drugs. This study focused on the preparation of a novel biocompatible nanocarrier based on bacterial cellulose (BC) in the presence of exosome (Exo) for the controlled release of 5‐fluorouracil (5‐FU), known as 5‐FU.Exo@BC. The physicochemical properties of 5‐FU.Exo@BC were thoroughly characterized using field emission scanning electron microscopy (FESEM), differential scanning calorimetry (DSC), Fourier‐transform infrared spectroscopy (FTIR), and X‐ray diffraction (XRD). These results confirmed the successful preparation of 5‐FU.Exo@BC. The release behavior of 5‐FU.Exo@BC compared with 5‐FU and 5‐FU@BC demonstrated a significant sustained release over 162 h. The release mechanism of the above three systems followed Korsmeyer‐Peppas with non‐Fickian diffusion for 5‐FU@BC and 5‐FU.Exo@BC. Furthermore, the viability of HT‐29 cells (human colon cancer cell lines) against BC, 5‐FU@BC and 5‐FU.Exo@BC indicated that 5‐FU has promising efficacy in 5‐FU.Exo@BC system. Subsequently, the prepared bio‐nanocomposite could be suggested as a potential drug delivery system with an effective controlled‐release function.

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Section: Determination Of %Dl and %Eesupporting

confidence: 90%

“…In addition, the n value of 5-FU was greater than 0.85 indicating that Case-II transport and the release behavior of 5-FU@BC and 5-FU.Exo@BC followed non-Fickian diffusion with n values ranging from 0.43-1. [33,40] Therefore, BC could affect the drug release behavior.…”

Section: Kinetic Behaviormentioning

confidence: 99%

Preparation and Characterization of 5‐Fluorouracil Loaded Cellulose and Exosome Nanocarriers: Sustained Release Behavior and Cytotoxicity Studies**

et al. 2023

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“…Considering the drug loading percentage of most nanocarriers is generally less than 10% [30], the above designed carriers were improved the drug loading that was due to conjugating the drug to BC as a polymer with various binding sites. The drug loading percentage of calcium alginate/sodium cellulose sulfate microcapsule for BSA was 38.14% [31], Ketamin@PEG-PLGA was 39.1% [32] and also, paclitaxel@BSA nanoparticles was 27.1% [30] that comparable with the achievement results of this study. Additionally, encapsulation e ciency values were upper than folic acid-loaded in a chitosan nanoparticles and cellulose nanocrystals (62%) [33] and zidovudine-loaded in a carboxy methyl cellulose and compritol-PEG carrier (18%) [34] and in the range of paclitaxel loaded poly(N-vinylpyrrolidone)-b-poly(epsilon-caprolactone) nanoparticles [30].…”

Section: Determination Of %Dl %Eesupporting

confidence: 89%

“…The correlation coe cients of three kinetic models are shown in Table 1. Based on the results, the release pro le of 5-FU, 5-FU@BC and 5-FU.Exo@BC was tted well with Korsmeyer-Peppas release kinetic model and the n value of 5-FU was greater than 0.85, hence, the release behavior followed by Fickian diffusion and 5-FU@BC and 5-FU.Exo@BC were between 0.43-0.85, thus, the drug release followed by non-Fickian diffusion [31]. Therefore, BC could affect the drug release behavior.…”

Section: Kinetic Behaviormentioning

confidence: 71%

Cellulose/Exosome Nanocarrier for Improved Prolonged Release of 5-Fluorouracil: Preparation, Characterization, Drug Release Behavior and Cytotoxicity

Saeidifar

Seyedahmadi

Javadpour

et al. 2021

Preprint

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Designing of nanoparticle drug delivery systems and improving the efficacy of anticancer drugs are a great deal of effort in the recent years. In this study, a novel biocompatible nanocarrier based on bacterial cellulose (BC) in presence of exosome (Exo) was prepared to controlled release of 5-fluorouracil (5-FU), (5-FU.Exo@BC). The physicochemical properties of 5-FU.Exo@BC was characterized using field emission scanning electron microscopy (FESEM), Differential Scanning Calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), and X-ray Diffraction (XRD) techniques that confirmed the successful preparation of 5-FU.Exo@BC. The release behavior of 5-FU.Exo@BC compared to 5-FU and 5-FU@BC demonstrated a significant sustained release during 162 h. The release mechanism of the above three systems followed Korsmeyer-peppas with non-Fickian diffusion for 5-FU@BC and 5-FU.Exo@BC. In addition, the viability of HT-29 cells (human colon cancer cell line), towards BC, 5-FU@BC and 5-FU.Exo@BC indicated the promising efficacy of 5-FU into 5-FU.Exo@BC. Subsequently, the prepared bio-nanocomposite could be proposed as a potential drug delivery system with effective controlled-release function.

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“…LbL is a well-established technique to manufacture structurally diverse materials by the sequential deposition of the opposite polyelectrolyte coatings . LbL has already been associated with alginate microgels to deliver small molecules − and proteins . In drug delivery, the polyelectrolyte coating on the microgels can improve and modulate the drug encapsulation efficiency, which allows the release of a massive drug release only after the rupture of the outer polyelectrolyte membrane.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Biomimetic Microgels for 3D Cell Culture and Nonviral Gene Delivery

et al. 2021

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Localized release of nucleic acid therapeutics is essential for many biomedical applications, including gene therapy, tissue engineering, and medical implant coatings. We applied the substrate-mediated transfection and layer-by-layer (LbL) technique to achieve an efficient local gene delivery. In the experiments presented herein, we embeded lipoplexes containing plasmid DNA encoding for enhanced green fluorescent protein (pEGFP) within polyelectrolyte alginate-based microgels composed of poly(allylamine hydrochloride) (PAH), chondroitin sulfate (CS), and poly-L-lysine (PLL) with diameters between 70 and 90 μm. Droplet-based microfluidics was used as the main process to produce the alginate (ALG)-based microgels with discrete size, shape, and low coefficient of variation. The physicochemical and morphological properties of the polyelectrolyte microgels were characterized via optical microscopy, scanning electron microscopy (SEM), and zeta potential analysis. We found that polyelectrolyte microgels provide low cytotoxicity and cell− material interactions (adhesion, spreading, and proliferation). In addition, the microsystem showed the ability to load lipoplexes and a loading efficiency equal to 83%, and it enabled in vitro surface-based transfection of MCF-7 cells. This approach provides a new suitable route for cell adhesion and local gene delivery.

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Self-assembly of polyelectrolyte complexes microcapsules with natural polysaccharides for sustained drug release

Cited by 21 publications

References 61 publications

Preparation and Characterization of 5‐Fluorouracil Loaded Cellulose and Exosome Nanocarriers: Sustained Release Behavior and Cytotoxicity Studies**

Preparation and Characterization of 5‐Fluorouracil Loaded Cellulose and Exosome Nanocarriers: Sustained Release Behavior and Cytotoxicity Studies**

Cellulose/Exosome Nanocarrier for Improved Prolonged Release of 5-Fluorouracil: Preparation, Characterization, Drug Release Behavior and Cytotoxicity

Layer-by-Layer Biomimetic Microgels for 3D Cell Culture and Nonviral Gene Delivery

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