Self-healing/pH-responsive/inherently antibacterial polysaccharide-based hydrogel for a photothermal strengthened wound dressing

Actinomycin-X2-Immobilized Silk Fibroin Film with Enhanced Antimicrobial and Wound Healing Activities

“…Such differences could be due to the bacterial infection preventing the repair of the upper epidermis, and the A-5 group containing Ac.X2 can overcome this problem early. At the same time, it was observed that there was large number of collagen fibers and muscle fibers, but the A-5 treated samples showed obvious high densities of collagen fibers [ 72 , 73 ], while the control did not, and the performance of muscle fibers was also lacking. On the other hand, SF has been reported to promote wound healing by activating the classic NF-κB signaling pathway [ 74 ], which has been associated with pro-inflammatory cytokines.…”

pH-Responsive wound dressings: advances and prospects

“…Besides the inherent antibacterial activity of QCS and berberine in hydrogels, the photothermal effect greatly improved the antibacterial properties of hydrogels, reducing the number of colonies of S. aureus and E. coli to 3.5% and 4.3%. 61 The photothermal effect has attracted much attention in recent years. Hydrogels with photothermal effect can not only help enhance their antibacterial ability, but also broaden the application range of hydrogels by designing temperature sensitivity based on the photothermal effect.…”

Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

“…CS is transformed into QCS through a process called quaternization. There are several reports on different quaternization methods of CS; however the quaternization reaction using a cationic epoxide, glycidyl trimethyl ammonium chloride (GTMAC), has been extensively studied due to the facile synthesis and purification steps of the product as well as the high biocompatibility of the modified polymer ( Figure 1 b) [ 32 , 33 , 34 ]. In an aqueous solution containing 2 v / v % acetic acid and temperature ranging from 55 to 80 °C, CS is reacted with the epoxide group of glycidyl trimethyl ammonium chloride to give the water-soluble, cationic CS derivative.…”

“…These bonds are easily formed via the reaction of a carbonyl group, an aldehyde, or a ketone, with a primary amine, a hydrazine or a hydrazide, respectively ( Scheme 2 ), and possess reversible properties, thus enabling the formation of self-healing materials. Moreover, it was shown that hydrogels based on reversible Schiff base junctions possess higher mechanical strength compared to their physically cross-linked counterparts [ 32 ].…”

“…More recently, composite hydrogels comprising QCS cross-linked with OHA through imine bond formation were prepared [ 32 ]. The hydrogels were loaded with a natural antibacterial agent, berberine (BBH), the epidermal growth factor (EGF), and poly(3, 4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) as a photothermal agent, and released their cargo at the acidic wound area.…”