Self-Nanoemulsifying Powder of Isotretinoin: Preparation and Characterization

Chavda, Hitesh; Patel, Jaimeen; Chavada, Gordhan; Dave, Shruti D; Patel, Ankini; Patel, Chhagan N.

doi:10.1155/2013/108569

Cited by 41 publications

(24 citation statements)

References 16 publications

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“…The resultant mixture was shaken on rotary flask shaken for 48 h at ambient temperature followed by centrifugation for 10 min at 6000 rpm. The supernatant was filtered through a membrane filter, and isotretinoin was determined spectrophotometrically at 344 nm [9].…”

Section: Screening Of Essential Oils Surfactants and Cosurfactants mentioning

confidence: 99%

Formulation, Characterization, and in Vitro Evaluation of Novel Microemulsion-Based Spray for Topical Delivery of Isotretinoin

Ashwini

Sanghani

Wani³

2018

Asian J Pharm Clin Res

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Objective: The present study aimed at the development of a suitable formulation for the treatment of acne using microemulsion-based topical spray system. In this study, we have designed and evaluated novel isotretinoin microemulsion-based spray and gel using basil oil. The rationale of work is to develop single topical formulation with multiple effects by combining effect of retinoid (prevention of comedones formation) and natural oil like basil oil (antibacterial, anti-inflammatory, and penetration enhancer).Methods: The optimized microemulsion-based spray comprised basil oil, Kolliphor RH40, Ethanol, and water was prepared by an aqueous titration method with the help of a ternary phase diagram. The microemulsion-based gel was prepared using Carbopol ETD 2020. The formulations were evaluated for their physicochemical properties. The formulations were subjected to antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus using cup plate method against hydrogen peroxide as standard. Finally, the drug released from spray and gel formulations was studied and compared to a commercially available product.Results: Isotretinoin microemulsion-spray showed highest flux (27.67±0.12 μg/cm2/h) in comparison to formulated microemulsion gel (21.81±0.103 μg/cm2/h) and conventional marketed gel (19.29±0.34 μg/cm2/h). The particle size of optimized microemulsion was found to be 68.43 nm. The results indicate that the formulated microemulsion-based spray presents a promising alternative for acne therapy.Conclusion: This mentioned delivery system presented several benefits such as photostability, better patient compliance, antibacterial activity, and good penetration into the desired skin layer when compared to in vitro diffusion of conventional gel and microemulsion-based gel.

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Section: Screening Of Essential Oils Surfactants and Cosurfactants mentioning

confidence: 99%

Formulation, Characterization, and in Vitro Evaluation of Novel Microemulsion-Based Spray for Topical Delivery of Isotretinoin

Ashwini

Sanghani

Wani³

2018

Asian J Pharm Clin Res

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“…The optimum formula shows a PI value lower than 0.5 which indicate uniformity droplet size distribution [40].…”

Section: Droplet Sizementioning

confidence: 95%

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

et al. 2019

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Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

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“…The value obtained was calculated using Eq. 1 and compared with ranges sited in (Table 4) (Chavda et al 2013).…”

Section: Measurement Of Angle Of Reposementioning

confidence: 99%

Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies

Ali

Hussein

2017

AAPS Open

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Candesartan cilexetil is an ester prodrug antagonist to angiotensin II receptor type 1 (AT1) used in management of many cardiovascular diseases. The absolute bioavailability of candesartan cilexetil is about (14-40%). Therefore, the paper aim was to prepare and evaluate solid self-nanoemulsifying drug delivery systems for candesartan cilexetil in order to improve its solubility, dissolution and stability. Solubility study was run in different vehicles to select the best excipients for dissolving candesartan cilexetil. Pseudo-ternary phase diagrams were constructed at 1:1, 2:1, 3:1 and 4:1 ratios and four formulations were prepared using various concentrations of cinnamon oil, tween 80 with poloxamer 407 mixture and transcutol HP as oil, surfactant mixture and co-surfactant, respectively. After this step about (0.2 milliliter) of each formulation was adsorbed on to two different adsorbent mixtures set which were: avicel 101 with aerosil 200 and avicel 101 with dibasic calcium phosphate anhydrous resulted in eight solid nanoformulations. All prepared formulations were evaluated for particle size distribution, polydispersity index, zeta potential, scanning probe microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffractometry and in vitro drug dissolution. It was found that release rate and extent for all prepared formulations were significantly higher (p < 0.05) than marketed tablet as well as plain drug powder. It could be concluded from the study that self-nanoemulsifying drug delivery system is a promising approach to improve solubility, wettability, dissolution and stability of candesartan cilexetil.

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Self-Nanoemulsifying Powder of Isotretinoin: Preparation and Characterization

Cited by 41 publications

References 16 publications

Formulation, Characterization, and in Vitro Evaluation of Novel Microemulsion-Based Spray for Topical Delivery of Isotretinoin

Formulation, Characterization, and in Vitro Evaluation of Novel Microemulsion-Based Spray for Topical Delivery of Isotretinoin

Optimization of Self-Nanoemulsifying Drug Delivery Systems of Lemongrass (Cymbopogon Citratus) Essential Oil

Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies

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