Self-setting apatite cement. VI. Possibility as bone substitute.

Takezawa, Yasumasa; Doi, Yutaka; Shibata, Shunichi; Uno, Katsumi; Horiguchi, T.; Wakamatsu, Nobukazu; Kamemizu, Hideo; Gyotoku, Tomoyoshi; Adachi, Masanori; Moriwaki, Yuji; Yamamoto, Kōji; Haeuchi, Yoshio

doi:10.2330/joralbiosci1965.31.240

Cited by 18 publications

(4 citation statements)

References 9 publications

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“…A number of studies have reported methods for reducing the setting time of CPC, for example by addition of OHAp seed crystals in CPC [8] and by controlling the particle sizes of CPC ingredients [9]. Results from these studies showed that the setting times can be shortened somewhat but not significantly.…”

Section: Introductionmentioning

confidence: 96%

Properties and mechanisms of fast-setting calcium phosphate cements

Ishikawa

Takagi

Chow

et al. 1995

J Mater Sci: Mater Med

148

101

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The setting time of a calcium phosphate cement consisting of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) was reduced from 30 to 5 min by use of a cement liquid that contained a phosphate concentration of 0.25 mol/I or higher. The diametral tensile strength and conversion of the cement ingredients to hydroxyapatite (OHAp) during the first 3 h were also significantly increased by the phosphate. However, the phosphate produced no significant effects on the properties of the 24-h cement samples. Results from additional experiments in a slurry system verified that the high phosphate concentration in the solution accelerated the formation of OHAp in the "I-FCP + DCPA system, and this reaction could explain the fast-setting properties of the cements.

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Section: Introductionmentioning

confidence: 96%

Properties and mechanisms of fast-setting calcium phosphate cements

Ishikawa

Takagi

Chow

et al. 1995

J Mater Sci: Mater Med

148

101

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“…2H20 or DCPD], or MCPM [Ca(H2PO4)2" H20] to form hydroxyapatite [Calo-x(HPO4)~,(PO¢)6-0, (OH)2 -x where 0 _< x _< 1 or HAp] did not reach completion within clinically relevant periods of time without the use of accelerators [1][2][3][4]. Typically the kinetics and setting time of these reactions are accelerated [4][5][6][7][8][9][10][11][12] by the addition of either large proportions of HAp filler and/or by accelerating the reaction using acidic solutions (phosphoric acid, acetic acid, maleic acid, etc. ).…”

Section: Introductionmentioning

confidence: 99%

“…While a number of studies have investigated strength development and/or setting times of CPCs containing TetCP and DCP/DCPD [4,5,7,9,14,16] an in-depth investigation and interpretation of the kinetics of these types of reactions has not been reported. The present investigation describes reactions between TetCP and DCPD proportioned to form both calcium deficient (Ca/P = 1.50) and stoichiometric (Ca/P--1.67) HAp.…”

Section: Introductionmentioning

confidence: 99%

The kinetics of calcium deficient and stoichiometric hydroxyapatite formation from CaHPO4�2H2O and Ca4(PO4)2O

TenHuisen

Brown

1996

J Mater Sci: Mater Med

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Isothermal calorimetry was performed on intimate mixtures of CaHPO4.2H20 and Ca4(PO4)20 constituted at Ca/P molar ratios of 1.50 and 1.67 to form the hydroxyapatite compositions Ca9HPOdPO4)sOH and Cal0(PO4)dOH)2, respectively, at complete reaction. The temperature range investigated was 15-70 °C. The effects of the reaction temperature on the rates of heat evolution during hydroxyapatite formation were determined. Reactions were carried out utilizing a liquid-to-solids weight ratio of 1.0. A two-stage reaction mechanism was observed regardless of the Ca/P ratio as indicated by the presence of two reaction peaks in the plots of the rates of heat evolution against time. An Arrhenius relationship was found between the rate and temperature for each reaction stage for both compositions. Apparent activation energies of 120 and 90 kJ/mol (Ca/P = 1.67) and 118 and 83 kJ/mol (Ca/P = 1.50), respectively, were calculated for the first and second reaction peaks. An Arrhenius relationship was also found between the time of maximum rate and temperature. The following qualitative reaction mechanism is proposed for each of the two reaction stages for both compositions studied. The first stage involves the complete consumption of CaHPO4.2H20 and the partial consumption of Ca4(PO4)20 to form a noncrystalline calcium phosphate and nanocrystalline hydroxyapatite. During the second stage the remaining Ca4(PO4)20 reacts with the noncrystalline calcium phosphate to form the final product, stoichiometric or calcium deficient hydroxyapatite.

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“…Compared to the £-ray-sterilized samples, the non-sterilized cement showed a fracture surface morphology that is smoother and denser. As mentioned earlier, the strength of a CPC is often determined by multiple factors, such as apatite content, 26) porosity level 5) and cement morphology. 27) Since the £-raysterilized and non-sterilized samples of the present study had similar porosity values, the observed higher strength in nonsterilized samples is considered primarily due to their denser morphology and aforementioned higher apatite conversion ratio.…”

Section: Effect Of Gamma Radiation On Properties Of a Calcium Phosphamentioning

confidence: 99%

Effect of Gamma Radiation on Properties of a Calcium Phosphate-Calcium Sulfate Composite Cement

Chen

Lee

et al. 2013

Mater. Trans.

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The present study investigates £-radiation effect on structure and selected properties of a tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA)/calcium sulfate hemihydrate (CSH) cement immersed in Hanks' solution. The results indicate that, at a dosage of 25 kGy, the working and setting times of the cement paste derived from £-ray-sterilized TTCP/DCPA/CSH powder did not change significantly. At 50 kGy or higher, however, both significantly decreased. A dose of 25 kGy caused the 1-d compressive strength of the cement to decrease by 15%. Further increases in £-ray dose did not further change the strength. After immersion for 1 day, the pH values of all non-sterilized and sterilized samples were in the range of 7.68.0. The XRD patterns of non-sterilized and sterilized powders were substantially similar. After immersion for 1 day, TTCP phase was still distinguishable, while CSH peaks were largely diminished and apatite phase became dominant. The non-sterilized sample had a significantly higher apatite conversion ratio than those of £-ray-sterilized samples. The average 1-d porosity values of all sterilized and non-sterilized samples were similar (3133%). The £-ray-sterilized cement samples had coralline type morphology with numerous tiny apatite crystals and micropores. Compared to the sterilized samples, the non-sterilized cement showed a smoother and denser morphology.

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Self-setting apatite cement. VI. Possibility as bone substitute.

Abstract: Abstract:Self-setting apatite cement was investigated to evaluate its use as a possible bone substitute in the rat femur.

Cited by 18 publications

References 9 publications

Properties and mechanisms of fast-setting calcium phosphate cements

Properties and mechanisms of fast-setting calcium phosphate cements

The kinetics of calcium deficient and stoichiometric hydroxyapatite formation from CaHPO4�2H2O and Ca4(PO4)2O

Effect of Gamma Radiation on Properties of a Calcium Phosphate-Calcium Sulfate Composite Cement

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