Self-sterilizing antibacterial silver-loaded microneedles

García, Laura E. González; MacGregor, Melanie; Visalakshan, Rahul Madathiparambil; Ninan, Neethu; Cavallaro, Alex; Trinidad, Abigail D.; Zhao, Yunpeng; Hayball, John D.; Vasilev, Krasimir

doi:10.1039/c8cc06035e

Cited by 75 publications

(25 citation statements)

References 22 publications

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“…This method allows for easy control of the number of silver nanoparticles immobilised on the surface and can lead to coatings providing full protection against bacterial colonisation, favourable integration of mammalian cells and tissue, and the absence of adverse immune responses. Another way to use these silver nanoparticles is to incorporate them in the material itself, as we did with nanocapsules, nanoparticles and microneedle patches [68,69,84]. Recently, we discovered that ultra-small 1-2 nm silver (and gold) nanoparticles synthesised in an aqueous medium have a very high potency against a range of clinically relevant pathogens, but also reduce expression of pro-inflammatory cytokines from immune cells and help wounds to close [88][89][90].…”

Section: Silver Containing Coatings and Materialsmentioning

confidence: 99%

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev

2019

Coatings

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This feature article begins by outlining the problem of infection and its implication on healthcare. The initial introductory section is followed by a description of the four distinct classes of antibacterial coatings and materials, i.e., bacteria repealing, contact killing, releasing and responsive, that were developed over the years by our team and others. Specific examples of each individual class of antibacterial materials and a discussion on the pros and cons of each strategy are provided. The article contains a dedicated section focused on silver nanoparticle based coatings and materials, which have attracted tremendous interest from the scientific and medical communities. The article concludes with the author’s view regarding the future of the field.

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Section: Silver Containing Coatings and Materialsmentioning

confidence: 99%

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev

2019

Coatings

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“…The distribution of the number of studies by characterization technique is detailed in Figure S2. In parallel, few studies characterized the devices with Fourier transform infrared spectroscopy (FTIR, n = 2) [55,64], X-ray diffraction (XRD, n = 2) [55,64], differential scanning calorimetry (DSC, n = 3) [55,64,65], and thermal gravimetric analysis (TGA, n = 2) [65,66] techniques. In comparison, FTIR, XRD, and DSC techniques were applied to nanostructured system characterization (Figure S1) in 11, 12, and 9 studies, respectively.…”

Section: Methods Employed In Quality Controlmentioning

confidence: 99%

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

2021

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The largest organ of the body provides the main challenge for the transdermal delivery of lipophilic or high molecular weight drugs. To cross the main barrier of the skin, the stratum corneum, many techniques have been developed and improved. In the last 20 years, the association of microneedles with nanostructured systems has gained prominence for its versatility and for enabling targeted drug delivery. Currently, the combination of these mechanisms is pointed to as an emerging technology; however, some gaps need to be answered to transcend the development of these devices from the laboratory scale to the pharmaceutical market. It is known that the lack of regulatory guidelines for quality control is a hindrance to market conquest. In this context, this study undertakes a scoping review of original papers concerning methods applied to evaluate both the quality and drug/protein delivery of dissolving and hydrogel-forming microneedles developed in association with nanostructured systems.

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“…Centrifugation or evacuation is required to remove air bubbles. MNs can be removed from the mold after solidification ( Figure 2B) [82]. The micromolding technique provides a simple and quick solution for mass production [83].…”

Section: Micromoldingmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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Self-sterilizing antibacterial silver-loaded microneedles

Abstract: Here we report the development of slef-sterilizing dissolving microneedles, a promising vehicle for vaccine and drug delivery.

Cited by 75 publications

References 22 publications

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Dissolving Microneedles Developed in Association with Nanosystems: A Scoping Review on the Quality Parameters of These Emerging Systems for Drug or Protein Transdermal Delivery

Engineering Microneedles for Therapy and Diagnosis: A Survey

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