Semen quality and cryopreservation in adolescent cancer patients

Bahadur, Gulam; Ling, Kun; Hart, Roger; Ralph, David; Wafa, R.; Ashraf, Ale Yasin; Jaman, N.; Mahmud, Sultan; Oyede, A.W.

doi:10.1093/humrep/17.12.3157

Cited by 101 publications

(60 citation statements)

References 38 publications

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“…Teens as young as 12 have the physical capacity and emotional maturity to provide semen samples and should be informed routinely of this option. 39 Yet a survey of over 200 male patients seen in major cancer centers revealed that only half recalled being told about sperm banking. The most common reason (other than having completed all family building at cancer diagnosis) for not banking sperm was not having been informed in time (25% of men who did not bank sperm).…”

Section: Fertility Preservation: the Need For Better Communication Bementioning

confidence: 99%

Sexuality and Fertility after Cancer

Schover¹

2005

Hematology

164

124

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As more people achieve long-term survival after cancer, sexual dysfunction and infertility have increasingly been recognized as negative consequences that impact quality of life. Sexual dysfunction is a frequent long-term side effect of cancer treatment, but damage to different underlying physiological systems is salient in men versus women. Men frequently have erectile dysfunction (ED) related to damage to the autonomic nervous system and/or reduced circulation of blood to the penis. Hormonal impairment of sexual function is less common. Women, in contrast, are able to overcome damage to autonomic nerves if genital tissues remain structurally intact and estrogenized. Female sexual dysfunction is frequently associated with sudden premature ovarian failure or direct effects of radiation fibrosis or scar tissue causing pain with sexual activity. The lack of validated interventions for sexual rehabilitation after cancer is a major problem, as is finding cost-effective ways of providing services. Concerns about fertility are also a major source of distress to people treated for cancer during childhood or young adulthood, yet many young survivors do not recall any discussion about future childbearing potential with their oncology team. Since fertility preservation is becoming more practical for both men and women, producing patient and professional educational materials and developing professional practice guidelines should be high priorities for oncology societies.As long as cancer treatments cannot be exclusively targeted to tumor cells, damage to the reproductive system will remain an important aspect of cancer morbidity. Problems with sexual function and fertility after cancer are not only ubiquitous, they are less likely to resolve with time than most other treatment side effects. Although not every cancer survivor cares about remaining sexually active, longterm sexual dysfunction has been documented in at least 50% of those treated for breast, prostate, colorectal or gynecological cancer.1 Most available information about sexual dysfunction and fertility is from patients treated for solid tumors. Distress about cancer-related infertility is typically highest among those diagnosed in their reproductive years. Although a much smaller percentage of people treated for cancer are affected by infertility than by sexual dysfunction, 1 in 71 men and 1 in 51 women are diagnosed with a malignancy before age 39.2 Although some cancer treatments can cause both sexual dysfunction and infertility, these two types of morbidity are frequently independent. For example, many young men treated with chemotherapy have poor semen quality, but with all but the highdose regimens, their testosterone levels and sexual function remain normal.3 Therefore, sexual function and fertility will be discussed in separate sections. Sexual Function, Gender, and Damage from Cancer TreatmentThe most common sexual problems after cancer treatment include loss of desire for sex in men or women, erectile dysfunction (ED) in men, and pain with sexual act...

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Section: Fertility Preservation: the Need For Better Communication Bementioning

confidence: 99%

Sexuality and Fertility after Cancer

Schover¹

2005

Hematology

164

124

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“…All pubertal boys with testis volumes above 10 -12 mL are encouraged to donate a semen sample before cancer therapy (43,44). Alternatively, electro-ejaculation or testicular sperm extraction from a biopsy can be used as a source to retrieve spermatozoa for boys unable to ejaculate (33).…”

Section: Cryopreservation Of Gametesmentioning

confidence: 99%

Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue or Germline Stem Cells

et al. 2006

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“…Chez la petite fille, la congelation et la conservation du tissu ovarien peut ~tre proposee. Chez le garcon pubere, des spermatozoides isoles du sperme ou des urines peuvent 6tre congeles [2] alors que la conservation du tissu testiculaire immature n'est actuellement pas proposee dans la majorite des pays chez le gars prepubere.…”

Section: Effet Des Traitements Anti-cancereux Sur La Spermatogeneseunclassified

What is the future of testicular tissue cryoconservation?

Vaudreuil

Rives

Milazzo

et al. 2005

Androl.

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RESUMEUne augmentation globale de rincidence des cancers est observde depuis vingt ans chez I'adulte comme chez I'enfant. Cependant, les progr&s rdalisds dans la prise en charge diagnostique et thdrapeutique de ces cancers ont transforme une maladie fatale en maladie curable. L'amelioration de refficacit6 des th6rapeutiques passe par une augmentation de leur toxicit6. Un grand nombre de complications ou s6quelles peuvent survenir chez ces survivants gudris d'une affection maligne de I'enfance, parmi lesquelles les alt(~rations du tissu gonadique sont de loin les plus fr(~quentes.Chez la petite fille, la cong61ation du tissu ovarien est devenue une pratique accessible et I'utilisation du tissu ovarien par greffe semble ouvrir des perspectives int6-ressantes. Chez le gargon pub~re, I'autoconservation de spermatozoYdes (~jacul(~s est envisageable, alors qu'en cas d ' d c h e c ou d~ de r(~alisation de ce recueil mais aussi chez le gargon non pub(~re, une autre stratdgie doit 6tre mise en oeuvre : le prel6vement chirurgical du tissu testiculaire et sa congdlation.Les protocoles de congdlation des gametes males matures djacules sont bien (~tablis. Cette methodologie a (~te transposee secondairement sur les spermatozo'ides pr~-levds au niveau de I'(~pididyme mais aussi extraits de fragments de tissu testiculaire. Cependant, la congdlation du tissu testiculaire adulte entier est moins r(~pan-due. Les protocoles de cong(Hation du sperme djaculd ont dtd (Habor(~s pour les spermatozo'ides et ne sont pas adaptds aux cellules germinales immatures, les spermatogonies. Ces cellules riches en cytoplasme prdsentent une certaine vulndrabilit(~ ~ la cong(Hation. Ainsi, les protocoles de congdlation restent ~ ddfinir tant sur la composition du milieu de cong(Hation, les temps d'incubation dans ce milieu, la courbe de descente en tempdrature que sur les modalitds de d(~congdlation.L'utilisation ult~rieure du tissu testiculaire immature c o n g e l e d(~finira la s t r a t e g i e de c o n g d l a t i o n . Deux options peuvent @tre retenues : (i) la cong61ation du tissu testiculaire entier ou (ii) la congdlation des spermatogonies en suspension. L'utilisation du tissu testicuiaire immature congel(~ pourra s'effectuer soit apr~s maturation in vitro des cellules germinales, soit par transplantation des cellules germinales ou du tissu entier par greffe autologue voire sugg~r6 par certains auteurs par x(~no-greffe. Cependant, cette derni~re approche soul(~ve des questions ~ la fois (~thiques et biologiques.

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Semen quality and cryopreservation in adolescent cancer patients

Cited by 101 publications

References 38 publications

Sexuality and Fertility after Cancer

Sexuality and Fertility after Cancer

Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue or Germline Stem Cells

What is the future of testicular tissue cryoconservation?

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