The control strategy is very important for semi-active control or active control systems. An integrated intelligent control strategy for building structures incorporated with magnetorheological (MR) dampers subjected to earthquake excitation is proposed. In this strategy, the time-delay problem is solved by a neural network and the control currents of the MR dampers are determined quickly by a fuzzy controller. Through a numerical example of a three-storey structure with one MR damper installed in the first floor, the seismic responses of the uncontrolled, the intelligently controlled, the passive-on controlled, and the passive-off controlled structures under different earthquake excitations are analyzed. Based on the numerical results, it can be found that the time domain and the frequency domain responses are reduced effectively when the MR damper is added in the structure, and the integrated intelligent control strategy has a better earthquake mitigation effect. magnetorheological damper, semi-active control, intelligent