We analyze return predictability for U.S. sectors based on fundamental, macroeconomic, and technical indicators and analyze whether return predictions improve tactical asset allocation decisions. We study the out-of-sample predictive power of individual variables for forecasting sector returns and analyze multivariate predictive regression models, including OLS, regularized regressions, principal component regressions, the three-pass regression filter, and forecast combinations. Using an out-of-sample Black–Litterman portfolio optimization framework and employing predicted returns as investors’ ‘views’, we evaluate the benefits of sector return forecasts for investors. We find that portfolio optimization with sector return prediction models significantly outperforms portfolios using historical averages as well as passive benchmark portfolios.