Seminal Concentration of Trace Elements in Fox and Relationships to Spermatozoa Quality

Massányi, Péter; Trandžík, J.; Naď, P.; Skalická, M.; Korénekova, Beáta; Lukáč, Norbert; Fabiś, M.; Toman, R.

doi:10.1081/ese-200056166

Cited by 22 publications

(10 citation statements)

References 21 publications

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“…[24] The excessive copper intake has a negative effect on the organs of reproduction of males and females. [25,26] The striking power of an organism thus decreases and animals become more susceptible to other diseases.…”

Section: Discussionmentioning

confidence: 99%

In vitrocopper inhibition of the rabbit spermatozoa motility

Roychoudhury

Massányi

2008

Journal of Environmental Science and Health, Part A

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Copper is an essential trace element that is strongly bioaccumulated. In this study the effects of this environmental contaminant on various spermatozoa motility parameters in vitro was analyzed. Rabbit spermatozoa were cultured with copper (CuSO(4).5H(2)O) which was added to semen in 5% solution and subsequently diluted 1:1-10. Analysis was carried out using a Computer Assisted Semen Analyzer (CASA) system in 3 time periods (0, 60 and 120 minutes). At Time 0, the highest motility in control group was detected. Motility in groups with copper administration was significantly (P < 0.05) decreased to 8.25-19.37%. The decrease of progressive motility was even more significant - in control 73.37 +/- 7.01% and in experimental groups up to 0%. At Time 60, motility significantly (P < 0.05) decreased from 59.62 +/- 11.40% to 7.50 +/- 3.66%. Progressive motility decreased from 49.62 +/- 16.10% to 0% in the group with the highest copper concentration. After 120 minutes of incubation the motility was 57.75 +/- 5.82% in control group and in all experimental groups it significantly (P < 0.05) decreased to 8.75%. Detailed evaluation of spermatozoa distance (DCL - distance curved line; DAP - distance average path; DSL - distance straight line) and velocity (VCL - velocity curved line; VAP - velocity average path; VSL - velocity straight line) parameters detected significant (P < 0.05) decrease in all studied markers in groups with copper addition in comparison with control group at all time periods. Straightness, linearity, wobble, amplitude of lateral head displacement and beat cross-frequency of spermatozoa were altered weakly. Detected data clearly confirm negative effects of high copper concentrations in semen on spermatozoa motility parameters and subsequent reproductive alteration in male sexual functions.

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Section: Discussionmentioning

confidence: 99%

In vitrocopper inhibition of the rabbit spermatozoa motility

Roychoudhury

Massányi

2008

Journal of Environmental Science and Health, Part A

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“…In our previous studies we described various lead concentrations in semen affecting the quality of spermatozoa. [25,26] Lead administration reflects in the appreciable decline in fertility status. In cell kinetic studies, significant declines in various cell populations, spermatids and mature spermatozoa were detected.…”

Section: Discussionmentioning

confidence: 99%

Lead-induced alterations in rat kidneys and testesin vivo

Massányi

Lukáč

Makarevich³

et al. 2007

Journal of Environmental Science and Health, Part A

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The purpose of this study was to assess the effects of lead administration on the kidney and testicular structure of adult rats. Rats received lead (PbNO(3)) in single intraperitoneal dose 50 mg/kg (group A), 25 mg/kg (group B) and 12.5 mg (group C) per kilogram of body weight and were killed 48 h following lead administration. After the preparation of histological samples the results were compared with control. After the lead administration dilated Bowman's capsules and blood vessels in interstitium of kidney with evident hemorrhagic alterations were noted. Quantitative analysis determined increased relative volume of interstitium and tubules. Also, the diameter of renal corpuscules, diameter of glomeruli and diameter of Bowman's capsule were significantly increased, especially in group A, with the highest lead concentration. In testes, dilatation of blood capillaries in interstitium, undulation of basal membrane and occurrence of empty spaces in seminiferous epithelium were detected. An apoptosis assay confirmed increased incidence of apoptosis in the spermatogenetic cells after the lead administration. Also further morphometric analysis showed significant differences in evaluated parameters between control and treated groups. The number of cell nuclei was decreased in lead-treated groups, which is concerned with the occurrence of empty spaces as well as with the higher apoptosis incidence in germinal epithelium. This study reports a negative effect of lead on the structure and function of kidney and testes.

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“…On the other hand, it was also documented that Ni has adversative effects on spermatozoa as well as on the structure and function of prostate gland, seminal vesicles and testis (Massanyi et al 2005). Furthermore, many studies, reporting animal mice models, have evidenced the links between spermatozoa-toxic effects and nickel (Pandey and Srivastava 2000).…”

Section: Nickel (Ni)mentioning

confidence: 96%

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

Zafar

Eqani

Bostan

et al. 2014

Environ Geochem Health

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Aims of this study were to provide firsthand data on the incidence of trace metals in human seminal plasma and find possible correlations between levels of toxic metals and semen quality of Pakistani population. Human semen samples were collected from male partners of couples undergoing infertility assessment at the National Institute of Health Islamabad (Pakistan). We investigated seventy-five seminal plasma samples, which were further categorized into three groups (normozoospermia, oligozoospermia and azoospermia) according to WHO guidelines. The concentration of 17 different toxic metals in human seminal plasma was determined simultaneously by using Inductively coupled plasma mass spectrometry (ICP-MS). Out of 17 trace metals, Cd and Ni showed significant difference (p < 0.05) among three monitored groups. Ni and Cd concentrations in the seminal plasma were negatively correlated with sperm concentration (r = -0.26, -0.29) and motility (r = -0.33, -0.37), respectively. This study suggested that exposure of Ni and Cd is mainly related with the consumption of contaminated dietary items, including ghee (cooking oil), flour and other agri-products. In some semen samples, the concentrations of Sn, V, Cu, Pb, Cr and Hg exhibited high levels suggesting a recent human exposure to surrounding sources. In Pakistani human semen samples, the levels of trace metals were lower and/or comparable to that found in populations of other countries. The results show the first evidence of the effect of toxic metals on semen quality and male infertility in Pakistan.

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Seminal Concentration of Trace Elements in Fox and Relationships to Spermatozoa Quality

Cited by 22 publications

References 21 publications

In vitrocopper inhibition of the rabbit spermatozoa motility

In vitrocopper inhibition of the rabbit spermatozoa motility

Lead-induced alterations in rat kidneys and testesin vivo

Toxic metals signature in the human seminal plasma of Pakistani population and their potential role in male infertility

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