Seminal plasma magnesium and premature ejaculation: a case‐control study

Aloosh, Mehdi; Hassani, Mohammad; Nikoobakht, Mohammad Reza

doi:10.1111/j.1464-410x.2006.06320.x

Cited by 14 publications

(9 citation statements)

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“…Rosecrans et al [ 8 ] also reported that there were significant correlations of K + ( r = 0.51), carnitine ( r = 0.54), and AST ( r = 0.70) in seminal plasma and serum, but we have not observed such phenomena in present study. Other comparative studies on biochemical markers in seminal plasma and serum were focused mostly on a single marker, such as the level of Mg in seminal plasma and serum samples obtained from normal fertile men and patients with premature ejaculation [ 9 ], and the levels of Ca and Mg in seminal plasma and serum from 113 men [ 10 ]. Moreover, the levels of protein, electrolytes, enzymes, and other components in seminal plasma samples in animals such as brown bears [ 11 ], rabbits [ 12 ], stallion [ 13 ], and bactrian camels [ 14 ] have been investigated, but the useful information was very limited in these studies.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men

Feng

Lü

Zhang

et al. 2015

BioMed Research International

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Introduction. The relationships of the biochemical components in seminal plasma and serum, and their origins and physiological effects in male reproductive system have been poorly understood. Methods. Based on the calibration and quality control measures, 26 biochemical markers, in seminal plasma and serum samples from 36 male infertility patients with nonazoospermia were detected and compared. Results. Only PA was undetectable in all seminal plasma samples. There were significant differences of all other 24 biochemical markers in seminal plasma and serum (P < 0.05) except for UA (P = 0.214). There were rich proteins in seminal plasma, and globulin accounted for about 90%. There were also abundant enzymes in seminal plasma, and the activities of ALT, AST, AKP, GGT, LDH, CK, and αHBDH in seminal plasma were significantly higher than those in serum while ADA was inversely lower. There were relatively low levels of Glu, TG, TC, and hsCRP in seminal plasma, but Glu was undetectable in 8 of 36 cases. Conclusions. The differences of the levels of biochemical markers in seminal plasma and serum might be associated with the selective secretion of testis, epididymis and male accessory glands, and the specific environment needed for sperm metabolism and function maintenance.

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Section: Discussionmentioning

confidence: 99%

A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men

Feng

Lü

Zhang

et al. 2015

BioMed Research International

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“…Some small studies in patients with normal kidney function postulate a role of decreased seminal magnesium in premature ejaculation. In a case–control study by Aloosh et al,38 it was demonstrated that there was a significant relationship between seminal plasma magnesium and premature ejaculation. The same results were found in a case–control study of 38 patients by Nikoobakht et al36 However, these studies have not found any relation between serum magnesium and premature ejaculation.…”

Section: Discussionmentioning

confidence: 97%

The impact of hypomagnesemia on erectile dysfunction in elderly, non-diabetic, stage 3 and 4 chronic kidney disease patients: a prospective cross-sectional study

Toprak¹,

Sarı²,

Koç³

et al. 2017

CIA

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BackgroundErectile dysfunction (ED) is common in older men with chronic kidney disease. Magnesium is essential for metabolism of nitric oxide which helps in penile erection. There is little information available about the influence of serum magnesium on ED. The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients.Subjects and methodsA total of 372 patients aged 65–85 years, with an estimated glomerular filtration rate of 60–15 mL/min/1.73 m2, were divided into two groups according to serum magnesium levels: hypomagnesemia, n=180; and normomagnesemia, n=192. ED was assessed through the International Index of Erectile Function-5. Hypomagnesemia is defined as serum magnesium <1.8 mg/dL.ResultsThe prevalence of ED was higher among hypomagnesemic subjects compared to that among normomagnesemics (93.3% vs 70.8%, P<0.001). Severe ED (62.8% vs 43.8%, P=0.037), mild-to-moderate ED (12.2% vs 5.2%, P=0.016), abdominal obesity (37.2% vs 22.9%, P=0.003), metabolic syndrome (38.4% vs 19.2%, P=0.026), proteinuria (0.83±0.68 vs 0.69±0.48 mg/dL, P=0.023), and C-reactive protein (6.1±4.9 vs 4.1±3.6 mg/L, P<0.001) were high; high-density lipoprotein cholesterol (48.8±14.0 vs 52.6±13.5 mg/dL, P=0.009), and albumin (4.02±0.53 vs 4.18±0.38 g/dL, P=0.001) were low in the hypomagnesemia group. Serum magnesium ≤1.85 mg/dL was the best cutoff point for prediction of ED. Hypomagnesemia (relative risk [RR] 2.27), age ≥70 (RR 1.74), proteinuria (RR 1.80), smoking (RR 21.12), C-reactive protein (RR 1.34), abdominal obesity (RR 3.92), and hypertension (RR 2.14) were predictors of ED.ConclusionOur data support that ED is related to hypomagnesemia in elderly patients with moderately to severely reduced kidney function.

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“…Decreased levels of magnesium result in an increase in thromboxane A2 levels, which leads to a rise in endothelial intracellular calcium and a decline in nitric oxide levels. These changes will ultimately result in cavernosal smooth muscle contraction, which might be a contributing factor to PE 100101…”

Section: Etiopathogenesis Of Pementioning

confidence: 99%

Premature ejaculation: an update on definition and pathophysiology

2019

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Premature ejaculation (PE) is the most common male sexual dysfunction, which represents a diagnostic as well as a therapeutic challenge for physicians. However, no universally accepted definition is currently available for PE. As a result, physicians continue to diagnose patients with PE according to major guidelines set by the professional societies. These guidelines either recommend the use of validated questionnaires or patient-reported outcomes. Recent efforts directed toward classifying PE may help provide a better understanding of the prevalence and risk factors of this disorder. While the exact etiology of PE has not been clearly elucidated, several risk factors have been strongly reported in the literature. Clearly, to understand the revised definition of PE, its etiology and pathophysiology is necessary to improve the clinical management of this medical condition and form the basis of future research in this regard. In this review, we highlight the past and current definitions of PE and present an appraisal on the classifications and theories suggested for the etiopathogenesis of PE.

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Seminal plasma magnesium and premature ejaculation: a case‐control study

Cited by 14 publications

References 11 publications

A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men

A Pilot Comparative Study of 26 Biochemical Markers in Seminal Plasma and Serum in Infertile Men

The impact of hypomagnesemia on erectile dysfunction in elderly, non-diabetic, stage 3 and 4 chronic kidney disease patients: a prospective cross-sectional study

Premature ejaculation: an update on definition and pathophysiology

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