SEN virus infection among patients on maintenance hemodialysis in southern Taiwan

Dai, Chia‐Yen; Chuang, Wan‐Long; Chang, Wen‐Yu; Chen, Shinn‐Cherng; Sung, Ming-Hsing; Hsieh, Ming‐Yen; Hsieh, Ming‐Yuh; Wang, Liang‐Yen; Tsai, Jer‐Chia; Yu, Ming‐Lung

doi:10.1016/j.jinf.2004.10.007

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…This is in accordance with Abd El-Hady et al 3 results that documented the prevalence of HCV and HBV by 27.3% and 29.1% in hemodialysis patients and negative control group. It also matched with Dai et al 17 results who reported the prevalence of HCV and HBV in hemodialysis patients as 24.2% and 7.1% respectively and negative blood donors. While Abdel Hady et al 18 findings stated that, the HCV was detected in 25.3% of hemodialysis group with negative controls and HBV was detected in 35% and 30.6% of hemodialysis patients and blood donors respectively with nonsignificant difference This may be due to the difference in control group characteristics.…”

Section: Discussionsupporting

confidence: 90%

Prevalence of SEN Virus and Torque Teno Virus in Hemodialysis Patients and Healthy Blood Donors in Menoufia University Hospitals

Elaskary

Elgendy²,

Elbassal³

et al. 2023

Egyptian Journal of Medical Microbiology

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Background: Blood transfusion and hemodialysis are considered major sources for blood-borne infections by different ways as the equipment, surfaces, and personnel, not only for HCV and HBV but also for SENV and TTV. Objectives: To determine the prevalence of SENV-D/H and TTV among HD patients and blood Donors (control group) in relation to HBV and HCV infection in Menoufia University Hospitals. Methodology: Serum samples from all tested HD patients and blood donors were investigated for ALT, AST by automated chemistry analyzer, anti HBsAg. and HCV antibodies by immunoassay. Also, SENV-D/H and TTV were detected by nested PCR. Results: Total SENV prevalence was 67.5% & 9.6% for HD patients and controls respectively. TTV had a prevalence of 38.9% in HD group and 17.8% in controls. SENV& TTV coinfection was 12.1% and 3.8% for HD patients and controls respectively. Non-significant association between different SENV genotypes, TTV infections and HBV or HCV infections. The positivity of SENV and TTV infections were significantly related to increased duration of hemodialysis, history of blood transfusion and elevated AST and ALT. Conclusions: SENV and TTV are more prevalent in hemodialysis patients than controls. Duration of hemodialysis, history of blood transfusion, and elevated ALT and AST are significantly related to SENV and TTV infection. They have non-significant role in increasing the severity of HBV or HCV infection among hemodialysis patients.

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Section: Discussionsupporting

confidence: 90%

Prevalence of SEN Virus and Torque Teno Virus in Hemodialysis Patients and Healthy Blood Donors in Menoufia University Hospitals

Elaskary

Elgendy²,

Elbassal³

et al. 2023

Egyptian Journal of Medical Microbiology

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“…This discrepancy is not surprising: actually a geographical distribution of SENV variants has been noted and differences between regions in the same country have been reported [12]. Moreover, none of the patients included in the present study was HIV‐1 co‐infected and, as previously demonstrated, SENV variant distribution is different between patients with different risk factors [12,13].…”

Section: Discussionmentioning

confidence: 55%

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

Moriondo

Resti

Betti

et al. 2006

Journal of Viral Hepatitis

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SEN is a newly discovered blood-transmissible virus. Among its variants, SENV-D and -H are most often associated with non-A, -E hepatitis. Very little is known about the risk of vertical transmission of the virus. By using polymerase chain reaction with specific primers for SENV-D and -H, we investigated the prevalence of SENV-H and -D infection, the transmission rate of SENV infection and clinical features of SENV-infected children in 89 hepatitis C virus (HCV)-positive human immunodeficiency virus type 1-negative mothers. SENV infection was found in 36 (40%) mothers, and SENV-D was more frequent than SENV-H infection (34/36, 94%vs 5/36, 14%, P < 0.01). No difference in SENV infection rates was found between injection drug user (IDU) mothers (17/51, 33%) and mothers with no risk for bloodborne infection (19/38, 50%, P = ns). SENV-H infection was found only in IDU mothers and mothers with HCV genotype1b. Both SENV-D and -H can be transmitted to the offspring with an overall rate of 47%. Vertical transmission of HCV does not facilitate SENV infection of the offspring. Among 17 SENV-infected children, none was co-infected with HCV. Maternal HCV genotype or viral load does not interfere with mother-to-infant transmission of SENV. Persistence of SENV infection was demonstrated in 100% of infected children after 1-year follow-up, but none had clinical evidence of liver disease.

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“…This result indicates that SEN-V and HCV/HBV are unlikely to transmit by common routes. No SEN-V-infected hemodialysis patients had clinical or biochemical signs of liver disease in previous reports (4-6). In our study, PD patients with SEN-V-H viremia had lower ALT levels than noninfected patients.…”

Section: Discussionmentioning

confidence: 72%

“…SEN-V infection is high in patients on maintenance hemodialysis. Kobayashi et al reported a prevalence of 37.6% among hemodialysis patients in Japan (4) and Dai et al reported a prevalence of 61.6% among hemodialysis patients in southern Taiwan (6), but Schroter et al reported a low prevalence, at 10.9%, in hemodialysis patients (5). In our study, the prevalence of SEN-V infection is about 32.6% in healthy adults and 27.7% in patients on PD.…”

Section: Discussionmentioning

confidence: 99%

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Sen Virus Infection in Patients on Peritoneal Dialysis

Hsu

Wang

et al. 2007

Perit Dial Int

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Background Many reports have demonstrated SEN virus (SEN-V) infection rates in hemodialysis patients, but the SEN-V infection rate in peritoneal dialysis (PD) patients has never been reported. In this study, we determined the prevalence rate of SEN-V viremia in a PD population. Methods Serum samples from 47 PD patients and a control group of 43 subjects from the general population at their health examination were assayed for SEN-V-D and -H viremia using polymerase chain reaction. Results The proportions of female gender ( p = 0.001), previous transfusion ( p < 0.0001), and higher mean serum AST level ( p = 0.012) were significantly higher in PD patients. The prevalence rates of SEN-V-D and/or -H viremia were not significantly different between PD patients and controls (27.7% vs 32.6%). SEN-V-D(+) patients had lower mean duration of PD than SEN-V(–) patients. Mean ALT level was significantly lower in SEN-V-H(+) than in SEN-V(–) patients (12.8 ± 5.8 vs 19.6 ± 12.1 (IU/L), p = 0.025). None of the SEN-V-infected PD patients had overt clinical or biochemical signs of liver disease. There were no statistically significant differences in prevalence of SEN-V-D and/or -H viremia between automated PD (APD) patients and continuous ambulatory PD (CAPD) patients. Conclusions These results indicate that the SEN-V infection rate is not different between healthy individuals and PD patients. Infection with SEN-V is not associated with evident liver disease in PD patients and SEN-V infection rate is not different between APD patients and CAPD patients.

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SEN virus infection among patients on maintenance hemodialysis in southern Taiwan

Cited by 8 publications

References 21 publications

Prevalence of SEN Virus and Torque Teno Virus in Hemodialysis Patients and Healthy Blood Donors in Menoufia University Hospitals

Prevalence of SEN Virus and Torque Teno Virus in Hemodialysis Patients and Healthy Blood Donors in Menoufia University Hospitals

SEN virus co‐infection among HCV‐RNA‐positive mothers, risk of transmission to the offspring and outcome of child infection during a 1‐year follow‐up

Sen Virus Infection in Patients on Peritoneal Dialysis

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