Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis

Zhu, Hong; Zhao, Huizi; Xu, Songbing; Zhang, Yuan; Ding, Yuhao; Li, Jun; Huang, Cheng; Ma, Tao

doi:10.1016/j.phrs.2021.105926

Cited by 13 publications

(5 citation statements)

References 37 publications

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“…There is a strong body of evidence in support of the role of cytokine-induced JAK/STAT signaling serving as a regulator of hepatic fibrosis and regenerative activity (67). Zhu et al found sennoside A to be capable of inhibiting SOCS1 and decreasing HSC proliferation in liver fibrosis through the inhibition of inflammation (68). Accordingly, additional work should focus on the relationships between these TNF-a-and IFN-g-associated genes, gene-gene interactions, and the pathogenesis of LC.…”

Section: Discussionmentioning

confidence: 99%

The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

Zheng

Fang

et al. 2023

Front. Immunol.

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BackgroundInflammation serves as an essential driver of liver cirrhosis (LC) incidence. Accordingly, a meta-analysis was carried out to explore the association between specific polymorphisms in the interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) genes and the incidence of LC based on comparisons of genotype and allele frequencies.ObjectivesTo study the relationship between TNF-α rs361525 and IFN-γ rs2430561 polymorphisms and the risk of LC.MethodsA database search was performed for all studies published as of September 10, 2022. The strength of risk relationships was assessed based on odds ratios (ORs) with 95% confidence intervals (CIs).ResultsPooled analyses were conducted for one common TNF-α polymorphism (rs361525) as well as one common IFN-γ polymorphism (rs2430561). Both of these SNPs were identified as LC-related risk factors. Specifically, rs361525 was related to LC incidence in both alcoholic liver cirrhosis (OR: 1.86, 95%CI: 1.03-3.34) and hepatitis B virus (HBV)-related cirrhosis cases (OR: 1.44, 95%CI: 1.00-2.06) when using an allelic contrast model. Moreover, rs2430561 was significantly related to LC in an Asian population (OR: 1.45, 95%CI: 1.13-1.86) and in the context of HBV-related cirrhosis (OR: 1.48, 95%CI: 1.13-1.93) when using an allelic contrast model.ConclusionThese findings indicate that rs361525 and rs2430561 represent LC-related risk factors, although additional large-scale clinical and case-control studies will be vital to confirm these results.

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Section: Discussionmentioning

confidence: 99%

The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

Zheng

Fang

et al. 2023

Front. Immunol.

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“…NOX4 [76], SOCS1 [69] and NAT2 [77] expressions were shown to play an important role in diabetes mellitus, but these genes might be involved in the progression of COVID-19. NOX4 [78] and SOCS1 [79] were reported to be associated with liver injury, but these genes might be novel targets for COVID-19. NOX4 [80] and SOCS1 [81] were shown to participate in facilitating the secondary infections.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

Vastrad¹,

Vastrad²

2022

Preprint

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The ongoing pandemic of coronavirus disease 2019 (COVID-19) has made a serious public health threat globally. To discover key molecular changes in COVID-19 and its secondary complications, we analyzed next-generation sequencing (NGS) data of COVID-19. NGS data (GSE163151) was screened and downloaded from the Gene Expression Omnibus database (GEO). Differentially expressed genes (DEGs) were identified in the present study, using DESeq2 package in R programming software. Gene ontology (GO) and pathway enrichment analysis were performed, and the protein-protein interaction (PPI) network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network were established. Subsequently, receiver operating characteristic curve (ROC) analysis was used to validate the diagonostics valuesof the hub genes. Firstly, 954 DEGs (477 up regulated and 477 down regulated) were identified from the four NGS dataset. GO enrichment analysis revealed enrichment of DEGs in genes related to the immune system process and multicellular organismal process, and REACTOME pathway enrichment analysis showed enrichment of DEGs in the immune system and formation of the cornified envelope. Hub genes were identified from the PPI network, module analysis, miRNA-hub gene regulatory network and TF-hub gene regulatory network. Furthermore, the ROC analysis indicate that COVID-19 and its secondary complications with following hub genes, namely, RPL10, FYN, FLNA, EEF1A1, UBA52, BMI1, ACTN2, CRMP1, TRIM42 and PTCH1, had good diagnostics values. This study identified several genes associated with COVID-19 and its secondary complications, which improves our knowledge of the disease mechanism.

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“…In 2021, using the same cell line as with the animal model, it was shown that sennoside A consistently inhibits the expression of the liver fibrogenesis markers α -smooth muscle actin and type I collagen alpha-1 and suppresses the inflammatory response in vitro and in vivo. It can also promote SOCS1 expression in a DNMT1-dependent manner [ 49 ]. Besides, SOCS1 helps to protect against liver injury and fibrosis and may also protect against liver carcinogenesis [ 111 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic effects of herbal medicine

Lau

2023

Clin Epigenet

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Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic modification provides a potential link to gene expression changes that may be involved in the development of various chronic diseases, and targeting the epigenome becomes a plausible method for treating diseases. Traditional herbal medicine has gradually entered the vision of researchers due to its low toxicity and its effectiveness in treating diseases. As a matter of fact, researchers found that the possessed epigenetic modification capacity of herbal medicine had the ability to combat the progression of the disease, such as various types of cancer, diabetes, inflammation, amnesia, liver fibrosis, asthma, and hypertension-induced renal injury. Studies on the epigenetic effects of herbal medicine will provide valuable insights into the molecular mechanisms of human diseases, which may lead to new therapeutic approaches and diagnoses. Thus, this review summarized the impact of herbal medicine and its bioactive components on disease epigenome as examples of how utilization of epigenetic plasticity could be useful as the basis for the future development of targeted therapies in chronic diseases.

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Sennoside A alleviates inflammatory responses by inhibiting the hypermethylation of SOCS1 in CCl4-induced liver fibrosis

Cited by 13 publications

References 37 publications

The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

The TNF-α rs361525 and IFN-γ rs2430561 polymorphisms are associated with liver cirrhosis risk: a comprehensive meta-analysis

Comprehensive analysis of next-generation sequencing data in COVID-19 and its secondary complications

Epigenetic effects of herbal medicine

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