Senoinflammation: A major mediator underlying age-related metabolic dysregulation

Kim, Dae Hyun; Bang, EunJin; Arulkumar, Radha; Ha, Sugyeong; Chung, Ki Wung; Park, Min Hi; Choi, Yeon Ja; Yu, Byung Pal; Chung, Hae Young

doi:10.1016/j.exger.2020.110891

Cited by 17 publications

(15 citation statements)

References 147 publications

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“…In fact, ageing causes cellular and molecular changes in tissue homeostasis, and it is associated with telomere shortening as well as with a multi-component senescence-associated secretory phenotype (SASP), displaying pro-inflammatory cytokines, chemokines, extracellular matrix (ECM)-degrading proteins and other cell-cycle arrest signaling molecules [ 94 , 95 , 96 , 97 ]. All the above factors result in the progressive deterioration of the structure and function of any given organ at the tissue and cell levels [ 97 ]. CSC ageing leads to a senescent phenotype, and to a decreased ability to differentiate and to heal cardiac injuries.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Papa

Marracino

Fortini

et al. 2020

JCM

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Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion of mutated clones of blood cells. This event is known as “clonal hematopoiesis.” Clonal hematopoiesis is closely associated with age, and carriers show an increased risk of developing blood cancers. Clonal hematopoiesis of indeterminate potential is defined by the presence of clones carrying a mutation associated with a blood neoplasm without obvious hematological malignancies. Unexpectedly, in recent years, it has emerged that clonal hematopoiesis of indeterminate potential carriers also have an increased risk of developing cardiovascular disease. Mechanisms linking clonal hematopoiesis of indeterminate potential to cardiovascular disease are only partially known. Findings in animal models indicate that clonal hematopoiesis of indeterminate potential-related mutations amplify inflammatory responses. Consistently, clinical studies have revealed that clonal hematopoiesis of indeterminate potential carriers display increased levels of inflammatory markers. In this review, we describe progress in our understanding of clonal hematopoiesis in the context of cancer, and we discuss the most recent findings linking clonal hematopoiesis of indeterminate potential and cardiovascular diseases.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Papa

Marracino

Fortini

et al. 2020

JCM

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“…Recent studies provide strong evidence suggesting an essential role of chronic inflammation in the pathogenesis of the above-mentioned ARDs [2][3][4]. In addition, genotoxic stress, which is a component of a wide variety of pathological conditions, not only causes extensive DNA damage but also activates pathways leading to chronic inflammation (the ERK, JNK, and p38 MAPK pathways) and transcription of pro-inflammatory cytokines (TNF-α, IL-1β, interleukin 6 (IL-6)), chemokines (interleukin 8 (IL-8)), adhesion molecules (VCAM-1, ICAM-1, P-, E-selectin), and other pro-inflammatory enzymes including iNOS and COX-2 [5]. This in turn leads to an elevated pro-inflammatory status that is likely to set the stage for increased vulnerability to many ARDs [6].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Properties of Lilium candidum L. and Its Phytochemicals

Zaccai

Yarmolinsky²,

Khalfin

et al. 2020

Plants

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Lilium candidum L., known as Madonna, meadow, or white lily, is a bulbous plant from the Liliaceae family, originating in the Middle East. L. candidum has been abundantly used in folk medicine since ancient times to relieve a variety of ailments, including age-related diseases, burns, ulcers, and coughs. The aim of this article is to investigate the anti-inflammatory and anti-diabetic activities of L. candidum extracts and its active phytochemicals. Some active volatile phytochemicals were identified using gas chromatography–mass spectrometry (GC-MS) analysis. Significant (p < 0.001) anti-diabetic properties of the extracts kaempferol, linalool, citronellal, and humulene were demonstrated by an elevation in glucose uptake by adipocytes. The significant (p < 0.01) effect of the plant extracts kaempferol, citronellal, and humulene on the secretion of pro-inflammatory cytokines interleukin 6 (IL-6) and interleukin 8 (IL-8) was demonstrated using enzyme-linked immunosorbent assay. Altogether, L. candidum and its rich collection of phytochemicals hold promising medicinal potential, and further investigations of its therapeutic prospects are encouraged.

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“…During aging, multiple cellular stresses such as inflammation, oxidative stress, and endoplasmic reticulum stress affect the central nervous system (CNS) [1][2][3][4]. In particular, elevated inflammatory responses in the brain are common during aging [1,5].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Fatty Acid Composition Underlying Hypothalamic Inflammation in Aged Mice

Kim

Yang

et al. 2020

Molecules

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Degenerative diseases, which can develop during aging, are underlined by inflammatory processes. Hypothalamic inflammation triggered by elevation in circulating fatty acid levels is directly coupled to metabolic disorders. The present study aimed to investigate and characterize the hypothalamic inflammation and composition of fatty acids in the hypothalami of aged mice. We verified that inflammation and microglial activation occur in the hypothalami of aged mice by performing quantitative real-time PCR and using immunohistochemistry methods. In addition, we observed increased levels of various saturated fatty acids in the hypothalami of aged mice, whereas no major changes in the levels of circulating fatty acids were detected using gas chromatography with a flame ionization detector. Collectively, our current findings suggest that increases in saturated fatty acid levels are coupled to hypothalamic inflammation and thereby cause perturbations in energy metabolism during the aging process.

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Senoinflammation: A major mediator underlying age-related metabolic dysregulation

Cited by 17 publications

References 147 publications

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Medicinal Properties of Lilium candidum L. and Its Phytochemicals

Characterization of Fatty Acid Composition Underlying Hypothalamic Inflammation in Aged Mice

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