This paper is the second part of a two-part survey series on large-scale global optimization. The first part covered two major algorithmic approaches to large-scale optimization, namely decomposition methods and hybridization methods such as memetic algorithms and local search. In this part we focus on sampling and variation operators, approximation and surrogate modeling, initialization methods, and parallelization. We also cover a range of problem areas in relation to large-scale global optimization, such as multi-objective optimization, constraint handling, overlapping components, the component imbalance issue, and benchmarks, and applications. The paper also includes a discussion on pitfalls and challenges of current research and identifies several potential areas of future research.