Sensitive DNA electrical detection based on interdigitated Al/Al2O3 microelectrodes

Moreno-Hagelsieb, L.

doi:10.1016/j.snb.2003.10.036

Cited by 76 publications

(38 citation statements)

References 15 publications

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“…One impedance amplification approach is the (enzyme) label-catalyzed precipitation of an insoluble material onto the electrode [75][76][77][78]. Electroless deposition of silver onto metallic nanoparticle labels has also been used [37,[79][80][81]. Various methods have been reported for post-affinity attachment of charged and/or bulky particles that alter the interface impedance [82][83][84][85].…”

Section: Amplificationmentioning

confidence: 99%

Label‐Free Impedance Biosensors: Opportunities and Challenges

2007

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Impedance biosensors are a class of electrical biosensors that show promise for point-of-care and other applications due to low cost, ease of miniaturization, and label-free operation. Unlabeled DNA and protein targets can be detected by monitoring changes in surface impedance when a target molecule binds to an immobilized probe. The affinity capture step leads to challenges shared by all label-free affinity biosensors; these challenges are discussed along with others unique to impedance readout. Various possible mechanisms for impedance change upon target binding are discussed. We critically summarize accomplishments of past label-free impedance biosensors and identify areas for future research.

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Section: Amplificationmentioning

confidence: 99%

Label‐Free Impedance Biosensors: Opportunities and Challenges

2007

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“…This type of electrode surface reduces the nonspecific precipitation of silver that occurs on conventional noble-metal electrodes. A change in capacitance by a factor of at least 2, using DNA solutions down to 0.2 nM spotted on the electrodes, was observed [75].…”

Section: Voltammetric Analysismentioning

confidence: 97%

Gold Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors

Ambrosi¹,

Escosura‐Muñiz

Castañeda

et al. 2009

Biosensing Using Nanomaterials

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“…Another approach has been demonstrated by on-line DC resistance monitoring, which were performed during the autometallographic enhancement process of gold particle-labeled analytes [21]. Beside the described DC approaches, AC capacitance measurements offer a further method of detecting an electrical signal, which does not necessarily requires a fully conductive structure between the electrodes [22]. Recently, the conventional use of metal nanoparticles as labels was extended by enzyme-catalyzed metal deposition [23][24][25].…”

Section: Electrical Detectionmentioning

confidence: 99%

DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics

Fritzsche

Csáki

Möller

et al. 2007

BioMEMS and Nanotechnology III

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Metal (especially gold) nanoparticles exhibit unique electronic, optical, and catalytic properties. In order to utilize these properties, an integration of the particles into technical setups such as a chip surface is helpful. We develop techniques to use (bio) molecular tools in order to address and control the positioning of particles on microstructured chips. These techniques are utilized for novel DNA detection schemes using optical or electrical principles. Plasmonic properties of the particles and the combination of nano-apertures with particles are promising fields for further bioanalytical developments.On the other hand, methods for defined positioning of single molecules or molecular constructs in parallel approaches are under development, in order to provide needed defined nanostructures for applications in nanoelectronics. Connecting DNA with nanoparticles, metallization of DNA or positioning of individual DNA-structures over microstructured electrode gap including subsequent metal particle binding are important steps in this direction. The utilization of (bio) molecular tools and principles based on highly specific binding and self-assembly represent a promising development in order to realize novel nanoparticle-based devices for bioanalytics, nano-optics andelectronics.

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Sensitive DNA electrical detection based on interdigitated Al/Al2O3 microelectrodes

Cited by 76 publications

References 15 publications

Label‐Free Impedance Biosensors: Opportunities and Challenges

Label‐Free Impedance Biosensors: Opportunities and Challenges

Gold Nanoparticles: A Versatile Label for Affinity Electrochemical Biosensors

DNA-conjugated metal nanoparticle for bioanalytics, nanophotonics, and nanoelectronics

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