Sensitive Electrochemical Detection of Nereistoxin by Reductive Desorption from Au(111) and Au(100)

Nishiyama, Katsuhiko; Tsuruta, Keisuke; Ikeda, Mizuki; Shimada, Hiroshi; Kitamura, Yusuke; Ihara, Toshihiro

doi:10.5796/electrochemistry.84.349

Cited by 3 publications

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“…In our previous study, NRTs were adsorbed on a single-crystal Au surface and showed a unique reductive desorption behavior in 0.1 M KOH. 29 The reductive desorption wave was so characteristic that we could distinguish NRT from other thiolated aliphatic amines. The detection limit was as low as 1 nM using an Au(100) single crystal.…”

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confidence: 99%

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Electrochemical Sensing of Neurotoxic Agents Based on Their Electron Transfer Promotion Effect on an Au Electrode

et al. 2017

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An electrochemical molecular sensor based on a new principle is reported. Nereistoxin (NRT, 4-N,N-dimethylamino-1,2-dithiolane), a naturally occurring neurotoxin (nicotinic acetylcholine receptor agonist), was adsorbed on an Au electrode via Au-S covalent bonding and accelerated the electron transfer between the electrode and the marker, ferricyanide anion. The contrast between the electrochemical responses obtained with the bare and NRT-modified Au electrodes was more pronounced at a low ionic strength of the supporting electrolyte, KCl. In the presence of 1 mM KCl, almost a 0/1 contrast between the signals was obtained through electrostatic interaction between the protonated tertiary amino group of NRT and the anionic ferricyanide ion. No current was observed with an electrode modified with mercaptopropionic acid. An unusually low ionic strength thickened the electric double layer to the degree where current was not observed with the bare electrode. The effect of the electrostatic concentration of the marker ion becomes obvious under such conditions. Commercially available NRT-related pesticides such as Cartap and Bensultap were also detected using the same format after pretreatments by hydrolysis/reduction. The present sensing method was successfully applied to human serum with satisfactory sensitivity.

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confidence: 99%

“…Therefore, NRT adsorbs on the Au surface by Au–S bond formation. In our previous study, NRTs were adsorbed on a single-crystal Au surface and showed a unique reductive desorption behavior in 0.1 M KOH . The reductive desorption wave was so characteristic that we could distinguish NRT from other thiolated aliphatic amines.…”

mentioning

confidence: 99%