Seorang Anak Laki-Laki dengan Kolestasis, Cytomegalovirus dan Anemia: Laporan Kasus

Abstract

Introduction: Cholestasis can cause obstruction of substances that should be secreted into the duodenum for further digestive process. Causes of intrahepatic cholestasis in children less than 2 months of age include idiopathic neonatal hepatitis; infections such as Cytomegalovirus (CMV), Human Immunodeficiency Virus (HIV), toxoplasmosis, Urinary Tract Infection (UTI), sepsis; and metabolic disorders, resulting from long-term administration of Total Parenteral Nutrition, and part of a syndrome. The infection can be transmitted either vertically or horizontally. Objective: This case report aims to determine congenital infections that can occur in children during pregnancy. Method: This study is a case report that applies a descriptive observational method about a 2.5-month-old boy being treated at Dr. Kariadi Semarang with a diagnosis of cholestasis, cytomegalovirus, normochromic microcytic anemia. Data was obtained from primary and secondary sources. Results and discussion: This case report explains that transmission of CMV infection can occur from mother to fetus during pregnancy, thus causing congenital infection. This infection becomes a chronic infection in children, thus affecting Hb levels in the blood and causing anemia. Examination of bilirubin, liver enzymes, and ultrasound of the abdomen confirmed the diagnosis of cholestasis. A head CT scan and ABR test are important for long-term monitoring. Conclusion: Infections that occur in patients due to cytomegalovirus may be acquired intrauterine. Complete investigations are needed to establish the diagnosis, so that appropriate therapy can be given. Long-term monitoring is important for the presence of intracranial calcifications as well as hearing loss.

The Effect of Giving Pork Oil and Egg Yolk as Components of a High Fat Diet on The Hematological and Cholesterol Profiles of Mice (Mus musculus)

“…Figure 4 shows that Mean Corpuscular Hemoglobin (MCH), in the normal value of female mice is 15.80 pg, while in male mice it is 15.40 pg (Wirth-Dzięciołowska et al, 2008). In this study, the MCH result of the negative control treatment (standard feed) was 12.5 pg and the positive control result of the high fat diet (egg yolk and lard) was 13.2 Figure 5 shows that Mean Corpuscular Hemoglobin Concentration (MCHC), the normal value is 32-36 mg/dl (Mayangsari, 2021). In this study, it was found that the MCHC results of the positive control treatment (diet high in lard and lard) were lower and below the normal MCHC value compared to the MCHC results of the negative control treatment (standard feed).…”