Pemberian suplementasi zat besi untuk mencegah dan mengatasi anemia belum mampu memaksimalkan penurunan angka anemia pada anak. Zat besi yang tidak mencukupi kebutuhan harian, rendahnya penyerapan zat besi, dan kurangnya keanekaragaman makanan yang mengandung zat tersebut menjadi penyebab utama anemia pada anak. Kemampuan absorbsi makro dan mikro-nutrient sangat dipengaruhi oleh struktur histologi usus halus. Perbaikan struktur histologi usus halus dengan pemberian probiotik dan zinc pada kasus malnutrisi diharapkan mampu meningkatkan fungsi absorbsi, sehingga penyerapan nutrisi, terutama zat besi, dapat lebih baik. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh probiotik dan zinc terhadap kadar hemoglobin pada tikus malnutrisi.

Introduction: Cholestasis can cause obstruction of substances that should be secreted into the duodenum for further digestive process. Causes of intrahepatic cholestasis in children less than 2 months of age include idiopathic neonatal hepatitis; infections such as Cytomegalovirus (CMV), Human Immunodeficiency Virus (HIV), toxoplasmosis, Urinary Tract Infection (UTI), sepsis; and metabolic disorders, resulting from long-term administration of Total Parenteral Nutrition, and part of a syndrome. The infection can be transmitted either vertically or horizontally. Objective: This case report aims to determine congenital infections that can occur in children during pregnancy. Method: This study is a case report that applies a descriptive observational method about a 2.5-month-old boy being treated at Dr. Kariadi Semarang with a diagnosis of cholestasis, cytomegalovirus, normochromic microcytic anemia. Data was obtained from primary and secondary sources. Results and discussion: This case report explains that transmission of CMV infection can occur from mother to fetus during pregnancy, thus causing congenital infection. This infection becomes a chronic infection in children, thus affecting Hb levels in the blood and causing anemia. Examination of bilirubin, liver enzymes, and ultrasound of the abdomen confirmed the diagnosis of cholestasis. A head CT scan and ABR test are important for long-term monitoring. Conclusion: Infections that occur in patients due to cytomegalovirus may be acquired intrauterine. Complete investigations are needed to establish the diagnosis, so that appropriate therapy can be given. Long-term monitoring is important for the presence of intracranial calcifications as well as hearing loss.