Septal vasopressin induced preservation of social recognition in rats was abolished by pinealectomy

Neuropathology and behavior after short-term and long-term pinealectomy in the rat

“…One reason for this finding is that the cell loss in both the CA1 and CA3 was a modest one {<21%) and hence, was simply not sufficient enough to disrupt memory processes. This finding was in accordance with several studies that have demonstrated that pinealectomized rats are not impaired on several behavioral paradigms (Appenrodt & Schwartzberg, 1999;Appenrodt et al, 2002;Juszczak et al, 1996). Moreover, pinealectomy did not result in an increase in anxietyrelated behaviors on the elevated plus maze.…”

“…This is consistent with our previous finding that pinealectomy did not affect working memory as assessed by both a tactile and a standard radial arm maze task (De Butte et al, 2002). It is also consistent with other findings that they are not different on passive and active avoidance tasks (Appenrodt 8c Schwartzberg, 1999;Juszczak et al, 1996), and social memory tasks (Appenrodt et al, 2002).…”

Arginine vasopressin V1a receptor antagonist impairs maternal memory in rats

“…It is known that both central [23] and peripheral [24] AVP administration can improve social recognition and memory in rodents, and the distribution of the V1a receptor subtype in primates suggests that it has a role in higher cognitive functions, such as memory [25]. Exogenous AVP injected into the septum improves social recognition, and V1 receptor antagonists interfere with social recognition [26][27][28]. Brattleboro rats, which are incapable of synthesizing biologically active AVP in their hypothalamic nuclei, display impaired social recognition compared to normal Long-Evans rats, and the microdialysis administration of synthetic AVP improves social recognition in both rat strains [26,29].…”

Intraamygdalar Melatonin Administration and Pinealectomy Affect Anxiety Like Behavior and Spatial Memory

“…For instance, while the pinealectomy itself did not have a detrimental effect on cognitive performance in rats, the interaction of it with the other lesion (i.,e, lesion on habenula) impaired such performance (Lecourtier et al, 2005). Many studies have shown that pinealectomy did not have a significant effect on the acquisition and extinction of the active avoidance behavior (Appenrodt and Schwarzberg, 2003), anxiety behavior (Appenrodt and Schwarzberg, 2000), passive avoidance learning (Appenrodt and Schwarzberg, 1999), open field exploratory activity (Kovács et al, 1974), and social recognition (Appenrodt et al, 2002).…”