Septicaemia with Neisseria elongata ssp. Nitroreducens in a Patient with Hypertrophic Obstructive Cardiomyopathia

Hofstad, Tor; Hope, Ottar; Falsen, Enevold

doi:10.1080/003655498750003672

Cited by 18 publications

(8 citation statements)

References 8 publications

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“…A search of PubMed (the National Library of Medicine's bibliographic database of biomedical journals) from 1966 through mid-1999 located five reports of meningococcal supraglottitis: two from Colorado (2,4), one from Ohio (3), one from Singapore (5), and one from Helsinki, Finland (6). Including our patient in the series of six, the ages of the patients (three were women) were 44, 54, 60, 65, 81, and 95.…”

Section: Discussionmentioning

confidence: 99%

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Fulminant Meningococcal Supraglottitis: An Emerging Infectious Syndrome?

Schwam

Cox

1999

Emerg. Infect. Dis.

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We report a case of fulminant supraglottitis with dramatic external cervical swelling due to associated cellulitis. Blood cultures were positive for Neisseria meningitidis. The patient recovered completely after emergency fiberoptic intubation and appropriate antibiotic therapy. We summarize five other cases of meningococcal supraglottitis, all reported since 1995, and discuss possible pathophysiologic mechanisms

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Section: Discussionmentioning

confidence: 99%

“…We describe a rare case of meningococcal supraglottitis (2-6) further complicated by cervical cellulitis. Reports of five other cases suggest an emerging clinical syndrome due to this pathogen.…”

mentioning

confidence: 99%

Fulminant Meningococcal Supraglottitis: An Emerging Infectious Syndrome?

Schwam

Cox

1999

Emerg. Infect. Dis.

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“…3,7 Preexisting heart diseases (valvular or congenital heart disease) are the primary risk factors for N. elongata endocarditis including our case who had bicuspid aortic valve. 8 Endocarditis due to these saprophytic Neisseriae usually results in an acute febrile illness and a large vegetation. Disease is often destructive, associated with severe complications, especially systemic embolism and perivalvular abscesses.…”

Section: Discussionmentioning

confidence: 99%

Endocarditis due to Neisseria elongata: A case report and review of the literature

Youssef

Marroush

Levine

et al. 2019

Germs

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Introduction Neisseria elongata, which is part of the normal oropharyngeal bacterial flora, can be an aggressive organism causing serious infections including infective endocarditis. N. elongata infective endocarditis is rare and no current guidelines exist to direct antibiotic selection and/or duration of treatment.Case report We report a case of infective endocarditis due to N. elongata and a review of the literature. Our patient is a healthy young woman, who was found to have an aortic root abscess with valve perforation requiring valve replacement. Discussion N. elongata infective endocarditis typically affects the left cardiac chambers and is associated with high risk of embolization. A transesophageal echocardiogram should be performed as part of the initial workup to assess the extent of infection, as a high percentage of patients develop perivalvular abscess formation and/or valve perforation. Most patients require prolonged antibiotic therapy and early surgical intervention.Conclusions This case demonstrates the potential severity of N. elongata endocarditis. Further studies are needed to establish management guidance.

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“…Despite DGI being a rare complication, its incidence is currently increasing relative to the steady increase in the incidence of gonorrhea worldwide [45]. N. cinerea Blood Septicemia [127,128] Brain Meningitis [128] Genitourinary tract Genital infections [129] Urinary infection [130] Peritoneum Peritonitis [131] Eye Conjunctivitis/ophthalmia neonatorum [132,133] N. dumasiana Sputum (Insufficient clinical data) [134] N. elongata Heart Endocarditis [135,136] Blood Septicemia [137] Bone Osteomyelitis [138] N. flava Heart Rheumatic heart disease/ventricular septaldefect/endocarditis [139] Endocarditis [140] Blood Sepsis/conjunctival petechia [139] N. flavescens Heart Endocarditis [141,142] Brain Meningitis [143,144] Blood Septicemia [145,146] Lung Pneumonia/empyema [147] Genitourinary tract Genital infections [148] N. lactamica Brain Meningitis [149,150] Blood Septicemia [145,151] Pharynx Pharyngitis [152] Lung Cavitary lesion [153] Pneumonia [154] Genitourinary tract Genital infections [129,155,156] N. mucosa Heart Endocarditis [157][158][159] Brain Meningitis [160,161] Blood Septicemia…”

Section: Disseminated Gonococcal Infections (Dgis)mentioning

confidence: 99%

“…other than N. meningitidis and N. gonorrhoeae identified as causing meningitis include N. flavescens [143,144], N. lactamica [149,150], N. mucosa [160,161], N. sicca [177,178], and N. subflava [185][186][187]. Moreover, several non-gonococcal, non-meningococcal Neisseria species have been isolated from blood cultures, many of which have been associated with infections including endocarditis (see above, Section 4.1), septicemia and meningitis [124,127,128,137,139,145,146,151,162,169,186,190] ( Table 1).…”

Section: Meningitis and Septicemiamentioning

confidence: 99%

Atypical, Yet Not Infrequent, Infections with Neisseria Species

Humbert

Christodoulides

2019

Pathogens

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Neisseria species are extremely well-adapted to their mammalian hosts and they display unique phenotypes that account for their ability to thrive within niche-specific conditions. The closely related species N. gonorrhoeae and N. meningitidis are the only two species of the genus recognized as strict human pathogens, causing the sexually transmitted disease gonorrhea and meningitis and sepsis, respectively. Gonococci colonize the mucosal epithelium of the male urethra and female endo/ectocervix, whereas meningococci colonize the mucosal epithelium of the human nasopharynx. The pathophysiological host responses to gonococcal and meningococcal infection are distinct. However, medical evidence dating back to the early 1900s demonstrates that these two species can cross-colonize anatomical niches, with patients often presenting with clinically-indistinguishable infections. The remaining Neisseria species are not commonly associated with disease and are considered as commensals within the normal microbiota of the human and animal nasopharynx. Nonetheless, clinical case reports suggest that they can behave as opportunistic pathogens. In this review, we describe the diversity of the genus Neisseria in the clinical context and raise the attention of microbiologists and clinicians for more cautious approaches in the diagnosis and treatment of the many pathologies these species may cause.

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Septicaemia with Neisseria elongata ssp. Nitroreducens in a Patient with Hypertrophic Obstructive Cardiomyopathia

Cited by 18 publications

References 8 publications

Fulminant Meningococcal Supraglottitis: An Emerging Infectious Syndrome?

Fulminant Meningococcal Supraglottitis: An Emerging Infectious Syndrome?

Endocarditis due to Neisseria elongata: A case report and review of the literature

Atypical, Yet Not Infrequent, Infections with Neisseria Species

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