Serial In Vitro Marrow Culture in Acute Myelocytic Leukemia

Bull, Joan M C; Duttera, M. J.; Stashick, Eleanor; Northup, J. D.; Henderson, Edward S.; Carbone, Paul P.

doi:10.1182/blood.v42.5.679.679

Cited by 49 publications

(3 citation statements)

References 9 publications

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“…Robinson et al (29,30) found repeatedly a poor response to treatment in patients whose cells did not form colonies. However, Bull et al ( 5 ) and Curtis et al (7) did not find any correlation between CFU-C and the frequency of remission. In the hitherto most extensive study of ANLL patients (n=108), Moore et al (25) concluded that the growth of small clusters (3-20 cells) or colonies (>40 cells) was related to a more favourable prognosis than if large clusters were formed or ifthere was no growth at all.…”

Section: Prognostic Injluence Of Age Und Conventionul Heniutological mentioning

confidence: 92%

In Vitro Colony Studies in 87 Patients with Acute Nonlymphoblastic Leukemia

Hörnsten

Gahrton

Sundman

et al. 1982

Journal of Internal Medicine

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ABSTRACT. Colony‐forming cells (CFU‐C) in peripheral blood and bone marrow and colony‐stimulating activity (CSA) in mononuclear peripheral white blood cells were studied at diagnosis in 87 patients with acute nonlymphoblastic leukemia (ANLL). Absence of CFU‐C in peripheral blood was more frequent in patients who did not enter remission than in those who did, and survival was significantly shorter in CFU‐C‐negative than in CFU‐C‐positive patients. No correlation was found between CFU‐C in the bone marrow and frequency of remission or survival time. Absence of CSA was significantly more frequent in patients who did not enter remission than in those who did. Only 4 of 28 patients who lacked CSA entered remission. Survival was significantly longer in CSA‐positive than in CSA‐negative patients. Thus, CSA synthesis in peripheral mononuclear blood cells appears to be a valuable prognostic factor in ANLL.

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Section: Prognostic Injluence Of Age Und Conventionul Heniutological mentioning

confidence: 92%

In Vitro Colony Studies in 87 Patients with Acute Nonlymphoblastic Leukemia

Hörnsten

Gahrton

Sundman

et al. 1982

Journal of Internal Medicine

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“…We do not consider such mechanisms explicitly, but only assume the existence of some control system, which is governed by the total population of the neutrophil system consisting of both proliferative and nonproliferative cells. This assumption is the most novel and critical one that we make, and one for which we cannot provide any direct experimental evidence, although there is some indication that leukemic cells do act to inhibit the colony-forming capacity of normal proliferative cells (13,14,16). The principal justification for our assumptions resides in the comparison we shall make subsequently of the deductions from our model with some of the known kinetic characteristics of AML.…”

Section: Introductionmentioning

confidence: 98%

A mathematical model of the acute myeloblastic leukemic state in man

Rubinow¹,

Lebowitz²

1976

Biophysical Journal

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A dynamical mathematical model of the acute myeloblastic leukemic state is proposed in which normal neutrophils and their precursors, and leukemic myeloblasts, proliferate as distinct but interacting cell populations. Each population has a Go compartment, consisting of resting cells, that acts as a control center to determine the rate of proliferation. These rates are assumed to depend on the total number of cells in the combined populations. The presence of the leukemic population destabilizes the homeostatic state of the normal population, which is stable in the absence of leukemic cells, and drives the system to a new stable state consisting entirely of leukemic cells and no normal cells. Calculations based on the theory suggest that it is able to simulate the kinetic features of this disease state, at least in its typical manifestations.

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“…Using in vitro assays for cloning of human haemopoietic cells in vitro (Pike & Robinson, 1970) it has been repeatedly shown that cells from either bone marrow or blood of acute non-lymphatic leukaemia (ANLL) patients reveal defects of colony formation in soft-media cultures in vitro (Aye et all 1972;Bull et al, 1973;Brown & Carbone, 1971;Greenberg et all 1971;Granstrom & Gahrton, 1974;Iscove et al, 1971; Moore et al, 1973;Robinson et al, 1971;Vincent etal, 1977) or production of colony stimulating activity (CSA) (Golde et al, 1974;Goldman et al, 1976;Greenberg et al, 1971;Granstrom & Gahrton, 1974;Robinson & Entringer, 1974) in vitro.…”

mentioning

confidence: 99%

Response to Treatment in Acute Non‐lymphatic Leukaemia: Prognostic Value of Colony Forming and Colony Stimulating Capacities of Bone Marrow and Blood Cells Compared to Other Parameters

1980

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Growth of bone marrow and mononuclear white blood cells (MWBC) in soft-agar cultures was studied in 26 patients with untreated acute non-lymphocytic leukaemia (ANLL). Marrow and MWBC from 30 healthy volunteers served as controls. All ANLL patients revealed an abnormal growth in vitro. Patients with an increased number of clones in marrow cultures and large cluster predominance ('excessive growth') responded poorly to therapy with only one of 10 patients entering remission. On the contrary, only two of the 15 patients with a decreased clone number ('low growth') failed to achieve remission. The number of colonies and clusters in both bone marrow and blood cultures was significantly lower at presentation in patients who later entered remission than in those who did not. The correlations between the number of colonies and clusters in the blood and the marrow cultures were statistically significant. No significant correlations were found between prognosis or colony formation, on one hand, and the production of colony stimulating activity (CS)bA), by bone marrow and blood cells of ANLL patients, on the other. Nor could such correlations be found between prognosis, blood cell counts, and age. It is concluded that the growth pattero cytostatic drugs and particularly in selecting patients with a high probability to respond poorly to current cytostatic regimes.

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Serial In Vitro Marrow Culture in Acute Myelocytic Leukemia

Cited by 49 publications

References 9 publications

In Vitro Colony Studies in 87 Patients with Acute Nonlymphoblastic Leukemia

In Vitro Colony Studies in 87 Patients with Acute Nonlymphoblastic Leukemia

A mathematical model of the acute myeloblastic leukemic state in man

Response to Treatment in Acute Non‐lymphatic Leukaemia: Prognostic Value of Colony Forming and Colony Stimulating Capacities of Bone Marrow and Blood Cells Compared to Other Parameters

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