Serious life events among resistant and non-resistant MDD patients

Amital, Daniela; Fostick, Leah; Silberman, A.; Beckman, Michael J.; Spivak, Baruch

doi:10.1016/j.jad.2008.01.006

Cited by 77 publications

(49 citation statements)

References 24 publications

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“…In spite of the increased suicidality, our patients with TRD and non-TRD had similar severity of depression. This is in contrast with more severe symptoms of depression observed in patients with TRD (Amital et al 2008) that were treated not only with antidepressant, like in the present study, but with combination of antidepressants and antipsychotics.…”

Section: Discussioncontrasting

confidence: 93%

“…So far, only one study (Papakostas et al 2003) investigated the suicidality in TRD and found that more than half of patients with TRD reported thoughts or wishes of death. The higher number of previous suicide attempts in our TRD compared to non-TRD patients is in line with the results of Amital et al (2008). In spite of the increased suicidality, our patients with TRD and non-TRD had similar severity of depression.…”

Section: Discussionsupporting

confidence: 89%

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The lack of association between components of metabolic syndrome and treatment resistance in depression

et al. 2013

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(2013) The lack of association between components of metabolic syndrome and treatment resistance in depression. npivac@irb.hr Psychopharmacology, 230 (1). Conflicts of Interest:Authors declare no conflict of interest. All authors state that they have full control of all primary data and that they agree to allow the journal to review this data. Acknowledgments:This study was supported by the Croatian Ministry of Science, Education and Sport, grants numbers 098-0982522-2455; 098-0982522-2457; 109-1083509-3513; 108-1083509-3511.

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Section: Discussioncontrasting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

The lack of association between components of metabolic syndrome and treatment resistance in depression

et al. 2013

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“…9 TRD carries high suicide attempt risk: 27% of patients reported at least 1 suicide attempt, consistent with other reports of 31%, which was greater than the attempted suicide rate of 15% in non-TRD MDD patients. 10 The TRD patients were notable for multiple failed SSRI trials, suggesting that repetitive (> 3) SSRI trials in MDD may not be warranted. 11 More aggressive antidepressant treatments with potential efficacy in TRD were seemingly underutilized, including ECT (60%) and MAOIs (37%).…”

Section: J Clin Psychiatry 76:11 November 2015mentioning

confidence: 97%

Clinical Characteristics and Management of Treatment-Resistant Depression

Conway

Gebara²,

Walker³

et al. 2015

J. Clin. Psychiatry

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To the Editor: Approximately one-third of patients with major depressive disorder (MDD) are treatment resistant. 1,2 Despite high prevalence, the clinical characteristics and management of treatment-resistant depression (TRD) are not well described. We present a comprehensive clinical description of a case series of 79 well-characterized patients with TRD referred to a university-based TRD specialty clinic.Method. Of 104 patients referred to our TRD clinic from 2009 to 2014, 79 met clinic inclusion criteria: DSM-IV-TR-defined MDD with resistance to ≥ 3 antidepressant trials of adequate dose and duration and no diagnoses of bipolar I or II disorder, personality disorder, psychotic disorder, or alcohol or drug abuse/dependence. Medical records for psychiatric treatments within at least 5 years were obtained. Psychiatric history, including symptom, clinical, family, and treatment information, was obtained at the initial visit. Patients completed the Montgomery-Asberg Depression Rating Scale (MADRS). 3 Institutional review board approval and patient consent were obtained for research use of data.Results. Of the 79 patients, 67% (n = 53) were women; the mean age was 49.3 years (SD = 14.2). One-third (n = 26) were receiving disability support. The mean age at MDD onset was 24.3 years (SD = 13.8), with 50% of patients reporting MDD onset after age 18. The mean number of lifetime MDD episodes was 2.6 (SD = 1.7), with 70% (n = 55) of patients reporting ≥ 2 episodes; 30% (n = 24) reported 1 sustained MDD episode. The mean number of lifetime MDD years was 18.6 (SD = 10.0), with 51% (n = 40) of patients reporting ≥ 18 years. Most patients, 63% (n = 50), reported at least 1 psychiatric hospitalization; 21% (n = 17) reported ≥ 4 hospitalizations (maximum = 20). Of those hospitalized at least once, the mean number of hospitalizations was 3.8 (SD = 4.3); 43% (n = 34) of all patients reported ≥ 2 hospitalizations. At least 1

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“…Non-responders are at significantly elevated risk for chronic depression and its Laura Grosse and Livia A. Carvalho share first authorship Hemmo A. Drexhage and Veerle Bergink share last authorship Electronic supplementary material The online version of this article (doi:10.1007/s00213-015-3943-9) contains supplementary material, which is available to authorized users. major complications, including social and functional impairments, somatic illness, and suicide (Amital et al 2008).…”

Section: Introductionmentioning

confidence: 99%