Seroepidemiology of hepatitis E virus in Western Iran

Raoofi, Rahim; Nazer, Mohammad Reza; Pournia, Yadollah

doi:10.1016/s1413-8670(12)70330-6

Cited by 7 publications

(2 citation statements)

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“…However, exposure to HEV increases with age. This is consistent with most studies which reported a significant association between age and higher anti-HEV positive values, since the prevalence of the disease increases with age [ 26 , 29 , 31 , 36 ]. Similarly high seroprevalence was found among adult population older than 60 years in China (70–80%), adult population older than 80 years in Bangladesh (67%), and adult population older than 80 years in Hong Kong (52–60%) [ 16 ].…”

Section: Discussionsupporting

confidence: 92%

“…In the present study we investigated the HEV seroprevalence among adult population in Ahvaz city and found that anti-HEV IgG and IgM seroprevalence were 46.1% and 1.4%, respectively. The result of the current study is considerably higher than that reported among adults in other parts of Iran [ 16 ]: 9.3% in Nahavand [ 25 ], 8.1% in Isfahan [ 17 ], 7.8% in Western Iran [ 26 ], 7.3% in sari [ 27 ], and 7.9–15% in Tehran [ 28 ]; it is also higher than that reported among adult population of some other countries: 3.9% in United Kingdom [ 16 ], 16.8% in Germany [ 29 ], 7.3% in Spain [ 30 ], about 20% in Korea [ 31 ], 23% in Thailand [ 32 ], 39–42% in USA [ 33 ], and 5.9% in Turkey [ 16 ]; however, it is lower than that reported among rural population older than four years in Egypt (51–78%) [ 16 , 34 ], pregnant women in Nile Delta, Egypt (84%) [ 16 , 35 ], general population older than 11 years in central Malaysia (50–67%) [ 16 ], tribes population (50–100%) and adult population (16–77%) in Andaman Islands, India [ 16 ], and homeless children in Cochabamba city, Bolivia (66%) [ 16 ].…”

Section: Discussioncontrasting

confidence: 68%

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Prevalence of Hepatitis E Virus among Adults in South-West of Iran

Farshadpour

Taherkhani

Makvandi

2015

Hepatitis Research and Treatment

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Background. Knowledge regarding prevalence of HEV in general population can be an indicator of the public health and hygiene. Therefore, this study was conducted to evaluate the prevalence of HEV among adults in South-West of Iran. Methods. Blood samples were taken from 510 participants, 206 (40.4%) males and 304 (59.6%) females from February to July 2014. Detection of anti-HEV IgG and IgM antibodies was carried out by ELISA test. Results. The overall anti-HEV IgG and IgM prevalence rates were 46.1% and 1.4%, respectively. Anti-HEV IgG and IgM seropositivity were not statistically associated with gender and race/ethnicity. Meanwhile, there were significant differences between the age groups regarding HEV IgG and IgM seropositivity. HEV IgG seroprevalence increased with age from 14.3% in subjects aged 18–30 years to 71.4% in persons over 71 years old, and considerably individuals aged 61 to 70 years had the highest HEV prevalence (90.9%). Also, 5.7% in the age group 18–30 years and 2.2% in the age group 31–40 years were positive for anti-HEV IgM antibodies and the highest rate was observed in subjects aged 18–30 years. Conclusion. In conclusion, high HEV IgG seroprevalence of 46.1% was observed among adults in South-West of Iran.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 68%

Prevalence of Hepatitis E Virus among Adults in South-West of Iran

Farshadpour

Taherkhani

Makvandi

2015

Hepatitis Research and Treatment

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Hepatitis E virus in the countries of the Middle East and North Africa region: an awareness of an infectious threat to blood safety

2015

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In the MENA region, the role of HEV as an infectious threat to blood safety is under-investigated. More data are needed to quantify the risk of transmission and to assess clinical outcomes. This requires, at least, surveillance screening of donors and recipients for HEV markers using sensitive and specific serological tests. At the present time, serious consideration should be given to selective screening for certain groups of patients (e.g., immunocompromised, pregnant women and others) who commonly require blood transfusion and are at high risk of hepatic failure or chronicity from HEV infection.

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Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population

Echevarría

2014

Scientifica

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Human hepatitis E virus (HHEV) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclinical, unrecognized infections. The overall prevalence of antibody to HHEV is high in most of the former areas and low in most of the later ones, but wide regional differences have been recorded in both cases. “Hot spots” of HHEV infection would exist for both types of strains in particular regions or among particular populations of the world. Studies on pork derivatives, shellfish bivalves, and vegetables for HHEV contamination at the sale point need to be extended for evaluating the impact of the agent on food safety, and the meaning of the finding of HHEV genotype 1 genomes in urban sewage from developed countries should be established through active surveillance. Consensus about technical issues in regard to anti-HEV testing would improve the knowledge of the HHEV epidemiology. Studies in particular regions and populations, and introduction of molecular diagnosis in the clinical setting as a routine tool, would also be required.

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Seroepidemiology of hepatitis E virus in Western Iran

Cited by 7 publications

References 1 publication

Prevalence of Hepatitis E Virus among Adults in South-West of Iran

Prevalence of Hepatitis E Virus among Adults in South-West of Iran

Hepatitis E virus in the countries of the Middle East and North Africa region: an awareness of an infectious threat to blood safety

Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population

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