Serological Findings in a Case of Haemolytic Anaemia

Weiner, William J.; Battey, Diana A.; Cleghorn, T. E.; Marson, F. G. W.; Meynell, M. J.

doi:10.1136/bmj.2.4828.125

Cited by 92 publications

(13 citation statements)

References 5 publications

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“…Some precedence for such a concept is seen in the case of the autoantibodies to red cells in acquired hemolytic anemia of the warm variety. Here, the antibodies are rarely to the dominant Rho antigens but are usually directed against relative weak (rh") antigen (48). Also, in the work of Mackay and associates, in certain instances complement-fixing antibodies, measured with whole tissue extracts reacted poorly with the extracts from the patient's own tissues (49) compared to their reactions with extracts from tissues of other individuals.…”

Section: Discussionmentioning

confidence: 99%

Specificity of the Reaction Between Rheumatoid Factors and Gamma Globulin

Fudenberg

Kunkel

1961

The Journal of Experimental Medicine

125

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The possibility that the rheumatoid factors represent antibodies to v-globulin has been entertained for a number of years. This concept originated primarily from the observations that the various serological tests for rheumatoid factors require v-globulin either as antibody or as inert material, in order for agglutination to take place (1). The precipitin reaction with soluble aggregates of v-globulin and the interaction to give a complex detectable in the ultracentrifuge furnished additional evidence for this point of view (2-4). Recently, the demonstmtion that these factors in physical, chemical, and antigenic properties closely resembled classical antibodies of the 19S class, considerably strengthened the antibody concept (5-8). The apparent specificity for v-globulin, however, has not been clearly delineated.In 1956, Grubb and Laurell noted that certain rare rheumatoid sera could be utilized as test reagents for detecting genetic differences between human v-globulins (9). These results were confirmed and extended by various investigators (10-12). However, although the genetic differences demonstrable by these tests have been widely utilized by human geneticists (13-19), they have contributed little to an understanding of the rheumatoid factors involved. The possibility arose that a study of the interaction of different rheumatoid factors with a wide variety of v-globulins from single individuals might reveal specificity for certain types of "}'-globulin. Such specificity would considerably strengthen the antibody concept and perhaps throw light on the hypothesis that the rheumatoid factors represent autoantibodies directed against the patient's own type of v-globulin. Recent work by Oudin, Dray, and others have indicated a wide variety of antigenically different v-globulins in different individuals of the same species (20)(21)(22)(23)(24)(25). A modification (26) of the test system of Waller and Vaughan, utilizing incomplete Rh antibodies from single donors as a test system for rheumatoid factors, has been primarily employed in the present investigation (27).The results indicate a high degree of specificity for the reaction between individual rheumatoid factors and v-globulin in the form of incomplete Rh antibodies from single individuals. A large number of different rheumatoid factors are distinguishable according to their reactivity with such individual v-globu-* Aided by a grant from the National Foundation.

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Section: Discussionmentioning

confidence: 99%

Specificity of the Reaction Between Rheumatoid Factors and Gamma Globulin

Fudenberg

Kunkel

1961

The Journal of Experimental Medicine

125

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“…Thus, in the acquired hemolytic anemias the positive direct Coombs test has been considered to be a consequence of autoimmune mechanisms (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)40). This concept has gained considerable support by the demonstration of specificities of certain of these "antibodies" in acquired hemolytic anemia (41,42). Attractive as this hypothesis is the possibility of the production of abnormal globulins capable of attachment to erythrocytes by non-antigenic pathways cannot be ignored (21,22 (43)(44)(45) on the production of a positive direct and indirect Coombs test in the dog by infusing incompatible blood and in canine hemolytic disease of the newborn in which "incomplete antibodies" were implicated as the causative factor.…”

Section: Discussionmentioning

confidence: 99%

Positive Direct Coombs Test Induced by Phenylhydrazine1

Muirhead¹,

Groves²,

Bryan³

1954

J. Clin. Invest.

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“…J. 's blood group composition than A1 is to A2• Patients suffering from haemolytic anacmia occasionally form blood group specific antibodies, directed against one of their own blood group antigens as first described by Weiner, Battey, Marson and Meynell [14].…”

Section: Dlscussionmentioning

confidence: 99%