1995
DOI: 10.1128/jcm.33.1.209-211.1995
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Serological reactivity and viral genotypes in hepatitis C virus infection

Abstract: Patients infected with hepatitis C virus (HCV) were examined with four commercial HCV immunoblotting assays and for anti-GOR antibody to ascertain whether serological findings varied with the genotype of the infecting virus. The results indicate that patients infected with different HCV genotypes tend to show different immunoblotting profiles, mainly due to a low prevalence of antibodies to the viral region NS4 in patients infected with genotypes III and IV. Differences were more evident with second-than with … Show more

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Cited by 20 publications
(8 citation statements)
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“…Previously unidentified subtypes could be circulating in the region, which are detected by the core-ELISA, but not by the commercial kits. Kits using recombinant proteins derived from NS4 (5-1-1 and c100-3) have been shown to be poor antigens for nontype 1 genotypes [Chan et al, 1991;McOmish et al, 1993;Maggi et al, 1995;Zein et al, 19951. It is also possible that high levels of antibodies with nonspecific binding activity affected the core-ELISA to a greater extent than the commercial kit causing these aberrant results.…”
Section: Discussionmentioning
confidence: 99%
“…Previously unidentified subtypes could be circulating in the region, which are detected by the core-ELISA, but not by the commercial kits. Kits using recombinant proteins derived from NS4 (5-1-1 and c100-3) have been shown to be poor antigens for nontype 1 genotypes [Chan et al, 1991;McOmish et al, 1993;Maggi et al, 1995;Zein et al, 19951. It is also possible that high levels of antibodies with nonspecific binding activity affected the core-ELISA to a greater extent than the commercial kit causing these aberrant results.…”
Section: Discussionmentioning
confidence: 99%
“…In these assays, a recombinant NS5 antigen has been added to the four antigens used in the second-generation assays. These third-generation assays have higher sensitivities and specificities than secondgeneration assays and are much less strongly influenced by the infecting genotype (57,76,77).…”
Section: Hcv Diagnostic Assaysmentioning
confidence: 99%
“…The diversity of the HCV genome also has implications for the development of diagnostic assays and an effective vaccine. The reactivity of immunology-based assays for the detection of anti-HCV antibodies may depend on the genotypes of viral antigens (12,18).…”
mentioning
confidence: 99%