Serological Survey for Arthropod-Borne Virus Infections in the Philippines

Wm, Hammon; Wd, Schrack; Ge, Sather

doi:10.4269/ajtmh.1958.7.323

Cited by 84 publications

(47 citation statements)

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“…Throughout the second half of the 20th century and into the early years of the 21st century, ZIKV serologic surveys indicated that human infection was confined to central and western Africa and to areas of South and Southeast Asia (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). In addition, phylogenetic analysis was consistent with two distinct introductions from Uganda into West Africa and with one introduction from Uganda into Malaysia (16).…”

Section: The Discovery and Early Characterization Of Zika Virusmentioning

confidence: 84%

“…Evidence of human ZIKV infection was obtained primarily via identification of ZIKV neutralizing antibodies in human serum (4,(6)(7)(8)(9)(10)(11)(12)(13). In serologic surveys conducted in Nigeria, Macnamara et al (10) noted that sera capable of neutralizing ZIKV in mouse protection experiments were also strongly associated with neutralization of DENV and YFV, suggesting serologic overlap or cross-reactivity.…”

Section: Zika Virus Diagnosticsmentioning

confidence: 99%

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Zika Virus: Diagnostics for an Emerging Pandemic Threat

2016

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Section: The Discovery and Early Characterization Of Zika Virusmentioning

confidence: 84%

Section: Zika Virus Diagnosticsmentioning

confidence: 99%

Zika Virus: Diagnostics for an Emerging Pandemic Threat

2016

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“…Epidemiological studies point to a widespread distribution of ZIKV in the northern half of the African continent, as well as in many countries in Southeast Asia, including Malaysia, India, the Philippines, Thailand, Vietnam, Indonesia, and Pakistan (2)(3)(4)(5)(6)(7)(8)(9). Many different Aedes species mosquitoes can account for the transmission of ZIKV, including Aedes aegypti (10,11), which at present is considered to be the main vector of the virus in South and Southeast Asia (11,12).…”

Section: Importancementioning

confidence: 99%

Biology of Zika Virus Infection in Human Skin Cells

Hamel

Dejarnac

Wichit

et al. 2015

J Virol

1,061

1,283

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Zika virus (ZIKV) is an emerging arbovirus of the Flaviviridae family, which includes dengue, West Nile, yellow fever, and Japanese encephalitis viruses, that causes a mosquito-borne disease transmitted by the Aedes genus, with recent outbreaks in the South Pacific. Here we examine the importance of human skin in the entry of ZIKV and its contribution to the induction of antiviral immune responses. We show that human dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells are permissive to the most recent ZIKV isolate, responsible for the epidemic in French Polynesia. Several entry and/or adhesion factors, including DC-SIGN, AXL, Tyro3, and, to a lesser extent, TIM-1, permitted ZIKV entry, with a major role for the TAM receptor AXL. The ZIKV permissiveness of human skin fibroblasts was confirmed by the use of a neutralizing antibody and specific RNA silencing. ZIKV induced the transcription of Toll-like receptor 3 (TLR3), RIG-I, and MDA5, as well as several interferonstimulated genes, including OAS2, ISG15, and MX1, characterized by strongly enhanced beta interferon gene expression. ZIKV was found to be sensitive to the antiviral effects of both type I and type II interferons. Finally, infection of skin fibroblasts resulted in the formation of autophagosomes, whose presence was associated with enhanced viral replication, as shown by the use of Torin 1, a chemical inducer of autophagy, and the specific autophagy inhibitor 3-methyladenine. The results presented herein permit us to gain further insight into the biology of ZIKV and to devise strategies aiming to interfere with the pathology caused by this emerging flavivirus. IMPORTANCEZika virus (ZIKV) is an arbovirus belonging to the Flaviviridae family. Vector-mediated transmission of ZIKV is initiated when a blood-feeding female Aedes mosquito injects the virus into the skin of its mammalian host, followed by infection of permissive cells via specific receptors. Indeed, skin immune cells, including dermal fibroblasts, epidermal keratinocytes, and immature dendritic cells, were all found to be permissive to ZIKV infection. The results also show a major role for the phosphatidylserine receptor AXL as a ZIKV entry receptor and for cellular autophagy in enhancing ZIKV replication in permissive cells. ZIKV replication leads to activation of an antiviral innate immune response and the production of type I interferons in infected cells. Taken together, these results provide the first general insights into the interaction between ZIKV and its mammalian host.

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“…During 1952À1953, in India, serum samples have been collected from residents of 38 localities in 6 states and tested for neutralizing antibodies against 15 different arthropod-borne viruses and a significant number of samples showed neutralizing activity against Zika virus (Smithburn, Kerr, Gatne 1954). Subsequently, the presence of antibodies against Zika virus was reported in several countries À Malaysia (Smithburn 1954), Borneo (Smithburn 1954), Vietnam (Pond 1963), Thailand (Smithburn 1954), Egypt , Philippines (Hammon et al 1958), Somalia (Henderson et al 1968), Kenya (Geser et al 1970), Gabon Saluzzo et al 1982), Nigeria (Monath et al 1973;Fagbami 1977;Fagbami 1979;Adekolu-John & Fagbami 1983), SierraLeone (Robin & Mouchet 1975), Indonesia (Olson et al 1981), Central African Republic (Saluzzo et al 1981), Pakistan (Darwish et al 1983), Senegal Monlun et al 1993), Nigeria (Baba et al 1999 (Lanciotti et al 2008;Duffy et al 2009), Cameroon (Fokam et al 2010), USA (Foy et al 2011), Cambodia , Zambia (Babaniyi et al 2015), and French Polynesia (Aubry et al 2015).…”

Section: Epidemiology Transmission and Spreadmentioning

confidence: 99%

Zika virus – emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives – a comprehensive review

Singh

Dhama

Malik

et al. 2016

Veterinary Quarterly

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This review converses the Zika virus which has attained global concern due to its rapid pandemic potential and impact on humans. Though Zika virus was first isolated in 1947, till the recent large-scale outbreak which occurred in Micronesia, in 2007, the virus was placed into the innocuous pathogen category. The World Health Organization on 1 February 2016 declared it as a 'Public Health Emergency of International Concern.' Of the note, American as well as Pacific Island strains/isolates is relatively closer to Asian lineage strains. The African and American strains share more than 87.5% and 95% homologies with Asian strains/isolates, respectively. Asian strains form independent clusters, except those isolated from China, suggesting relatively more diversity than African strains. Prevention and control are mainly aimed at the vector population (mosquitoes) with Aedes aegypti being the main species. Surveys in Africa and Asia indicated seropositivity in various animal species. However, so far its natural reservoir is unknown. There is an urgent need to understand why Zika virus has shifted from being a virus that caused mild illness to unforeseen birth defects as well as autoimmune-neurological problems. Unfortunately, an effective vaccine is not available yet. Availability of cryo-electron microscopy based on 3.8 A resolution revealing mature Zika virus structure and the probable virus attachment site to host cell would provide critical insights into the development of antiviral treatments and vaccines.

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Serological Survey for Arthropod-Borne Virus Infections in the Philippines

Cited by 84 publications

References 0 publications

Zika Virus: Diagnostics for an Emerging Pandemic Threat

Zika Virus: Diagnostics for an Emerging Pandemic Threat

Biology of Zika Virus Infection in Human Skin Cells

Zika virus – emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives – a comprehensive review

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