Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Huai, Pengcheng; Li, Furong; Li, Zhen; Sun, Lele; Fu, Xi’an; Pan, Qing; Yu, Gongqi; Chai, Zemin; Chu, Tongsheng; Mi, Zihao; Bao, Fangfang; Wang, Honglei; Zhou, Bingni; Wang, Chuan; Sun, Yonghu; Niu, Guiye; Zhang, Yuan; Fu, Fanghui; Lang, Xiaoqiao; Wang, Xiaoling; Zhao, Hui; Liu, Daina; Liu, Hong; Liu, Dianchang; Liu, Jian; Xu, Aiqiang; Zhang, Furen

doi:10.1186/s12879-019-3995-2

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…These studies had approximately 2.5-10 times lower HSV-2 seroprevalence compared to Nigeria. Also, contrary to the findings of many studies [27,[30][31][32][33], it was found that seroprevalence of HSV-2 was higher in males compared to females in Nigeria, but this observation should be interpreted with caution as only 3 studies with a total sample population of 14 were used to estimate the seroprevalence of HSV-2 among Nigerian males and as such the disparity may be due to sparseness of seroprevalence data amongst the Nigerian male population. The seroprevalence of 57.5% among HIV-infected patients is in tandem with the established trend of risk association between HSV-2 and HIV [34].…”

Section: Discussioncontrasting

confidence: 74%

Seroprevalence of herpes simplex virus types 1 and 2 in Nigeria: a systematic review and meta-analyses

Reward

Muo

Orabueze

et al. 2019

Pathogens and Global Health

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A source of comprehensive information on the prevalence of herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) can help researchers and policymakers address HSV related burden in the society. At the moment, this is not readily available. This study aims to fill this gap by attempting to estimate the seroprevalence of HSV-1 and HSV-2 infections in Nigeria on the basis of published data. A systematic review and meta-analysis including cross-sectional studies on HSV-1 and HSV-2 in Nigeria was conducted. Electronic databases including PubMed/MEDLINE, CENTRAL, African Journals Online (AJOL), ScienceDirect, WHO-Afro Library, WHO-IRIS and African Index Medicus were searched for English Language publications on HSV-1 and HSV-2. Seven relevant publications were identified. Seroprevalence measures of 3 and 23 for HSV-1 and HSV-2, respectively, were extracted. The pooled mean seroprevalences for HSV-1 and HSV-2 were 74.0% (37.4-99.4%) and 63.4% (56.1-70.4%) respectively. The mean seroprevalence of HSV-1 was higher among females, 82.4% (n = 509, CI, 36.6-100.0%), than males, 54.5% (n = 198, CI, 47.6-61.4%). The mean seroprevalence of HSV-2 were 51.8% (n = 1414, CI: 39.4-64.0%) and 86.5% (n = 162, CI: 80.8-91.3%) among healthy and clinical populations, respectively. The study was limited by the paucity of quality studies, variations in diagnostic methods and high heterogeneity in seroprevalence estimates. In conclusion, the seroprevalence of HSV-1 and HSV-2 remain high in Nigeria. Large and representative national epidemiological surveys covering all regions and specific groups are recommended.

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Section: Discussioncontrasting

confidence: 74%

Seroprevalence of herpes simplex virus types 1 and 2 in Nigeria: a systematic review and meta-analyses

Reward

Muo

Orabueze

et al. 2019

Pathogens and Global Health

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“…Therefore, improving HSV-2 related knowledge and the frequency of condom use is an effective method to prevent and control HSV-2 infection and transmission among MSM in Shenzhen. Most studies demonstrated that having multiple sex partners is associated with HSV-2 infection [ 31 , 32 ]. Although FAC3_1 (X 8 = Number of male sex partners in P6M) was not associated with HSV-2 infection in this study, it is necessary to prevent and control HSV-2 infection in MSM with multiple sexual partners.…”

Section: Discussionmentioning

confidence: 99%

Trends of HIV/Syphilis/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective study

et al. 2021

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Objectives To analyze the trends of HIV/syphilis/HSV-2 seropositive rate and explore the related factors with HSV-2 infection to provide the basis for adjusting STD intervention strategies and formulating prevention and control measures among MSM in Shenzhen. Methods Time-location sampling was conducted among MSM in Shenzhen in 2012, 2014, 2016, and 2018. Data on demographics, sexual behaviors and the laboratory test results of HIV, syphilis, HSV-2 were collected. The χ2 trend test was used to analyze the trends of HIV/syphilis/HSV-2 seropositive rate. The binary logistic regression model was used to explore the factors associated with HSV-2 infection. Results The seropositive rate of HIV fell significantly from 15.9% in 2012 to 8.7% in 2018 (Ptrend = 0.003), syphilis seropositive rate was significantly decreased from 20.4% in 2012 to 14.8% in 2018 (Ptrend = 0.025), HSV-2 seropositive rate had no significant change (16.7% in 2012 to 14.0% in 2018; Ptrend = 0.617). In principal component logistic regression analysis showed that FAC1_1 (X1 = Ever had sex with female, X2 = Gender of first sexual partner, X3 = Marital status, X4 = Age group), FAC2_1 (X5 = Education, X6 = Monthly income (RMB), X7 = Frequency of condom use in anal sex with men in the past 6 months), and FAC4_1 (X9 = History of STDs) were significantly associated with HSV-2 infection. Conclusions The seropositive rates of HIV and syphilis have dropped significantly but are still high. HSV-2 seropositive rate had no significant change and maintained a high level. It is necessary to continue strengthening HIV and syphilis interventions among MSM in Shenzhen. HSV-2 detection and intervention are urgently required for MSM, which might be another effective biological strategy further to control the HIV epidemic among MSM in Shenzhen.

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“…A study conducted among pregnant women in rural regions of India have shown a lower seroprevalence of HSV-2 relative to studies in a given region [24]. Other studies originating in China have also shown that the seroprevalence of HSV-2 was higher in individuals from the eastern region and urban areas of Shandong than those from other regions [25]. The other large epidemiological study on the occurrence of HSV in the Polish population covering 4 regions reported geographical place of residence as a significant risk factor for HSV-2 seropositivity [26].…”

Section: Discussionmentioning

confidence: 88%

Congenital herpes simplex virus infection among hospitalized infants in Poland

Rząd¹,

Nitsch–Osuch²,

Tyszko³

et al. 2021

Ann Agric Environ Med.

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Introduction and objective.Congenital herpes simplex virus infection (cHSV) is a rare entity and may pose a life-threatening disease for the newborns. Due to the public health and clinical importance of cHSV infection in infants, the recent data on this disease in Poland should be investigated. The aim of the study was to evaluate the incidence and other factors related to cHSV. Materials and method. The study is retrospective, population-based that utilised the hospital discharge records of cHSV patients. Data were obtained from National Institute of Public Health NIH -National Research Institute in Warsaw, Poland, covering the period 2014-2019.Results. The study group consisted of 1,573 cHSV newborns (841 males and 732 females). Among this group, 70.1% were infants up to 90 days of age and 3.6% were neonates up to 28 days of age. The mean and median age was 98 days (95% CI: 94.5-101.8, SD 74) and 70 days (IQR: 53-104), respectively. Based on the hospital registry the overall average cHSV incidence over the study period was estimated to be 69 per 100,000 live births. The number of cHSV infection fluctuated over the years 2014-2019 with a significant decreasing trend from 2015-2019 (P<0.01). A significantly higher cHSV incidence was observed among patients from urban than rural areas of Poland (88 vs 40/100,000 live births; P<0.001). Conclusions. CHSV incidence may be related to multifactorial conditions for the occurrence of this disease. Further studies on changes in the incidence of cHSV are needed.

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Seroprevalence and associated factors of HSV-2 infection among general population in Shandong Province, China

Cited by 11 publications

References 30 publications

Seroprevalence of herpes simplex virus types 1 and 2 in Nigeria: a systematic review and meta-analyses

Seroprevalence of herpes simplex virus types 1 and 2 in Nigeria: a systematic review and meta-analyses

Trends of HIV/Syphilis/HSV-2 seropositive rate and factors associated with HSV-2 infection in men who have sex with men in Shenzhen, China: A retrospective study

Congenital herpes simplex virus infection among hospitalized infants in Poland

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