Seroprevalence and risk factors of Toxoplasma gondii infection in stray dogs in northern China

Zhang, Xiaoxuan; Cai, Yanan; Wang, Chunfeng; Jiang, Jing; Xu, Yixin; Yang, Genhua; Zhao, Quan

doi:10.1007/s00436-015-4746-y

Cited by 12 publications

(4 citation statements)

References 33 publications

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“…It may cause asymptomatic infection or severe symptomatic infection including developmental defects, early embryonic death, stillbirth, or abortion to T. gondii-infected pregnancies (Dubey and Jones, 2008;Dubey and Dubey, 2010;Pan et al, 2017). Dogs are the intermediate hosts, and multiple studies have demonstrated the prevalence of T. gondii in dogs in a variety of countries or areas worldwide (Jiang et al, 2015;Zhang et al, 2015;Dubey et al, 2016;Rengifo-Herrera et al, 2017;Zarra-Nezhad et al, 2017). Although these serological surveys and diagnosis analysis of dogs infected T. gondii have been reported, the interactions between the host dog and the parasite T. gondii remain not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii Triggers Neutrophil Extracellular Traps Release in Dogs

Wei

Wang

Liu

et al. 2020

Front. Cell. Infect. Microbiol.

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Toxoplasma gondii (T. gondii) can cause zoonotic toxoplasmosis worldwide. Neutrophil extracellular traps (NETs) have been known as a novel effector mechanism against T. gondii infection in the innate system of humans, cats, and sheep. Dogs are the intermediate host of T. gondii, in which the use of NETs against T. gondii infection remains unclear. Thus, this study aims to examine the effects of T. gondii on NETs release in dogs, and to further investigate the mechanism involved in the process. T. gondii-triggered NETs were analyzed by scanning electron microscopy (SEM) and fluorescence confocal microscopy, and the mechanism of T. gondii-triggered NETs release was determined by using inhibitors and a fluorometric reader. The results showed that T. gondii tachyzoites significantly triggered NETs-like structures, which consisted of DNA decorated with neutrophil elastase (NE) and myeloperoxidase (MPO). Further investigations revealed that reactive oxygen species (ROS)-, NADPH oxidase-, Rac 1or p38 mitogen-activated protein kinase (MAPK)-signaling pathways were relevant to T. gondii tachyzoites-triggered NETs release. Moreover, zymosan-triggered NETs release was strikingly degraded by T. gondii tachyzoites treatment, indicating that T. gondii may escape from the NETs-based capture strategy. Taken together, promoting NETs release is suggested to limit motility and evade infection of T. gondii in dogs.

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Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii Triggers Neutrophil Extracellular Traps Release in Dogs

Wei

Wang

Liu

et al. 2020

Front. Cell. Infect. Microbiol.

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“…Toxoplasmosis is a zoonosis caused by T. gondii (Zhang et al 2015). It is widely parasitic in human and animal nucleated cells (Kang et al 2016).…”

Section: Introductionmentioning

confidence: 99%

A Seroepidemiological Survey of Toxoplasma gondii and Chlamydia Infection in Chickens, Ducks, and Geese in Jilin Province, Northeastern China

Yang

Yin

et al. 2020

Vector-Borne and Zoonotic Diseases

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Toxoplasma gondii and Chlamydia are common protozoan pathogens, which can pose health risks to people around the world and cause considerable economic losses. Although information on the seroprevalence of T. gondii and Chlamydia in chickens can be found in China, knowledge on the infection of these two diseases in rural chickens, ducks, and geese is limited. Therefore, blood samples from 377 chickens, 268 ducks, and 379 geese were taken from rural areas in seven cities in northeastern China, and their seropositivity was analyzed by the indirect hemagglutination antibody (IHA) test with a cutoff titer of 1:64. The overall seroprevalence of T. gondii and Chlamydia was 10.6% and 21.0%, respectively. Moreover, the free-range poultry (20.75% and 30.55%) have significantly higher seroprevalences than caged poultry (5.47% and 15.66%) (p < 0.001). Moreover, the seroprevalence of T. gondii in older and younger poultry was found to be 5.48% and 12.89%, and those in Chlamydia were 23.53% and 15.16%, respectively. There were significant differences between different ages (p < 0.05). But regarding the prevalence of both, it is not clear in this way which one is the prevalence for younger and older for each specific pathogen. Logistic regression analysis suggested that geography were considered as a risk factor for T. gondii infection in this study. Our study is the first report on the seroprevalence of T. gondii and Chlamydia in poultry in rural areas of Jilin Province, China. These data reflect that T. gondii and Chlamydia are widespread in poultry in northeastern China, leading to a risk of infection in human health. Therefore, the prevention and control of Toxoplasma and Chlamydia infection in poultry, other animals, and humans should be strengthened.

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“…It is estimated that one-third of the human population is infected by the parasite. The majority of infections are asymptomatic; however, T. gondii infection in pregnant women and immunocompromised patients can cause serious illnesses and even death (ZHANG et al, 2015). Similarly, infection in dogs may be asymptomatic, but clinical signs are variable and may include respiratory, digestive, ocular, and neuromuscular symptoms (HOSSEININEJAD et al, 2011;LANGONI et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii in dogs of riverside communities of Mato Grosso Pantanal, Brazil

Rodrigues

Almeida

Sorte

et al. 2016

Rev. Bras. Parasitol. Vet.

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Toxoplasma gondii is an intracellular protozoan with worldwide distribution and dogs act as sentinels of human infection. This search aimed to determine the occurrence of antibodies against T. gondii in dogs of the communities on the Cuiabá River, Mato Grosso and variables associated with infection. The dogs of the riverside communities in Cuiabá River, which includes Barranco Alto, Praia do Poço, Engenho Velho, Varginha, Bom Sucesso, Passagem da Conceição and São Gonçalo Beira Rio, were evaluated for the presence of T. gondii antibodies by indirect immunofluorescence antibody test (IFAT). The prevalence and factors associated with infection were calculated by chi-squared test (χ 2 ) or Fisher's exact test, and univariate and multiple analysis. Of the 248 dogs surveyed, 107 (43.1%) were seropositive for T. gondii. The seroprevalence ranged from 25.6% to 64.3%. There was no statistically significant difference between the communities studied (p > 0.05). As for the associated factors, the only statistically significant factor was that of dogs living with cats (p = 0.02), with approximately twice the risk of acquiring infection. In conclusion, the seroprevalence in dogs of riverside communities in the Baixada Cuiabana demonstrated that high rates of infection, being the factor associated with infection, contact with domestic cats.Keywords: Toxoplasma gondii, dogs, associated factors, Cuiabá River, Pantanal, Brazil. ResumoToxoplasma gondii é um protozoário intracelular com distribuição mundial e o cão atua como sentinela para infecção humana. Esta pesquisa teve por objetivo determinar a ocorrência de anticorpos contra T. gondii em cães de comunidades ribeirinhas ao Rio Cuiabá, Mato Grosso e as variáveis associadas à infecção. Os cães das comunidades ribeirinhas do Rio Cuiabá, que inclui Barranco Alto, Praia do Poço, Engenho Velho, Varginha, Bom Sucesso, Passagem da Conceição e São Gonçalo Beira Rio, foram avaliados para a presença de anticorpos para T. gondii pela reação de imunofluorescência indireta (IFI). A prevalência e fatores associados com a infecção foram calculados pelo teste de qui-quadrado (χ 2 ) ou exato de Fisher, e análise univariada e multivariada. Dos 248 cães estudados, 107 (43,1%) foram soropositivos para T. gondii. A prevalência variou de 25,6% a 64,3%. Não houve diferença estatisticamente significativa entre as comunidades estudadas (p > 0,05). Quanto aos fatores associados, o único fator estatisticamente significante o convívio com gatos (p = 0,02), com cerca de duas vezes mais risco de adquirir a infecção. Em conclusão, a soroprevalência em cães de comunidades ribeirinhas da Baixada Cuiabana demonstram altas taxas de infecção, sendo o fator associado à infecção, o contato com gatos domésticos.

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Seroprevalence and risk factors of Toxoplasma gondii infection in stray dogs in northern China

Cited by 12 publications

References 33 publications

Toxoplasma gondii Triggers Neutrophil Extracellular Traps Release in Dogs

Toxoplasma gondii Triggers Neutrophil Extracellular Traps Release in Dogs

A Seroepidemiological Survey of Toxoplasma gondii and Chlamydia Infection in Chickens, Ducks, and Geese in Jilin Province, Northeastern China

Seroprevalence of Toxoplasma gondii in dogs of riverside communities of Mato Grosso Pantanal, Brazil

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