Seroprevalence of human herpes virus 8 antibody in populations at high or low risk of transfusion, graft, or sexual transmission of viruses

Challine, Dominique; Roudot‐Thoraval, Françoise; Sarah, Turiaf; Laperche, Liliane; Boisson, Bruno; Mauberquez, Stephanie; Dubernet, Fabienne; Rigot, Pierrette; Lefrère, François; Mercier, Bernard; Brossard, Y.; Raffi, François; Girot, Robert; Loiseau, Pascale; Girard, Danièle; Claquin, J; Loty, B.; Lerable, J; Mariotti, Martine; Pawlotsky, Jean‐Michel; Lefrère, Jean‐Jacques

doi:10.1046/j.1537-2995.2001.41091120.x

Cited by 51 publications

(40 citation statements)

References 27 publications

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“…The high frequency of iatrogenic KS in Saudi Arabia reflects the 7% endemic seroprevalence of KSHV in healthy Saudi donors or patients with non-KS malignancies (412). Interestingly, transplant-associated KS is seen predominantly in kidney allograft recipients and not other solid-organ or bone marrow transplant recipients (230); kidney recipients have a greater than two-fold-higher seroprevalence than those at low risk of KS in France (85). Although Andreoni et al found that 21.4% of liver recipients, but only 8.6% of kidney recipients, seroconverted for KSHV, the risk of KS was higher in the kidney transplant recipients.…”

Section: Iatrogenic Ksmentioning

confidence: 99%

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Dourmishev

Palmeri

et al. 2003

Microbiol Mol Biol Rev

309

367

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Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection

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Section: Iatrogenic Ksmentioning

confidence: 99%

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Dourmishev

Palmeri

et al. 2003

Microbiol Mol Biol Rev

309

367

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“…[4][5][6][7][8][9] However, only a few studies have investigated risk factors for progression to KS among individuals coinfected with HIV and HHV-8.…”

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confidence: 99%

“…[1][2][3] Previous studies of acquired immunodeficiency syndrome (AIDS) patients have identified risk factors for infection with HHV-8, including sexual activity among homosexual men, intravenous drug use and blood transfusion. [4][5][6][7][8][9] However, only a few studies have investigated risk factors for progression to KS among individuals coinfected with HIV and HHV-8.…”

mentioning

confidence: 99%

Risk factors for Kaposi's sarcoma among HHV‐8 seropositive homosexual men with AIDS

Nawar

Mbulaiteye

Gallant

et al. 2005

Intl Journal of Cancer

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Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sectional analysis of 99 cases among 503 HHV-8 seropositive homosexual men with AIDS. Data were collected by computerassisted personal interviews and medical chart reviews. HHV-8 seroreactivity was determined by enzyme-linked immunosorbent assay for antibodies against HHV-8 K8.1 glycoprotein. KS was significantly less common in blacks compared to whites [risk ratio (RR) = 0.4; 95% CI = 0.2=0.8] and more common in subjects who had completed college (RR = 1.7; 95% CI = 1.1-2.7) or had annual income greater than $30,000 (RR = 1.5; 95% CI = 1.1-2.2). KS was less common in cigarette smokers (RR = 0.6; 95% CI = 0.5-0.9) and users of crack cocaine (RR = 0.4; 95% CI = 0.1-0.8). KS was less common in bisexual men compared to men who were exclusively homosexual (estimated RR = 0.6; 95% CI = 0.4-0.9) and inversely associated with number of female partners. KS was also less common in men who had received pay for sex (RR = 0.6; 95% CI = 0.4-1.0). These cross-sectional associations could be biased by potential differences in relative timing of HHV-8 and HIV infection, a postulated determinant of KS risk. Alternatively, our findings may reflect factors protective against KS in individuals infected with HHV-8. Future research should focus on identifying practical measures for countering KS that do not increase the risk of other diseases. Published 2005 Wiley-Liss, Inc.Key words: Kaposi's sarcoma; human herpesvirus; AIDS-related malignancy Human immunodeficiency virus (HIV)-related Kaposi's sarcoma (KS) is an opportunistic neoplasm caused by coinfection with human herpesvirus 8 (HHV-8).1-3 Previous studies of acquired immunodeficiency syndrome (AIDS) patients have identified risk factors for infection with HHV-8, including sexual activity among homosexual men, intravenous drug use and blood transfusion. [4][5][6][7][8][9] However, only a few studies have investigated risk factors for progression to KS among individuals coinfected with HIV and HHV-8.Homosexual men may be at greater risk of AIDS-related KS than are members of other HIV transmission groups, even adjusted for differences in prevalence of HHV-8.1 Furthermore, HHV-8-infected individuals progress to KS at different rates or frequently not at all, 10-12 suggesting the existence of cofactors that influence risk. We therefore examined potential associations with KS in a cross-sectional analysis of HHV-8 seropositive homosexual men with AIDS enrolled in the AIDS Cancer Cohort Study. Material and methodsThe National Cancer Institute's AIDS Cancer Cohort Study is directed toward identifying rates and risk factors for HIV-associated malignancies. From October 1997 to January 2000, 2,803 persons with Centers for Disease Control and Prevention-defined AIDS 13 were enro...

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“…The performance of these assays can be quite variable, and could account for the differences in seroprevalence reported in different studies (Pellett et al, 2003;Rabkin et al, 1998;Tedeschi et al, 2002). In North America and Northern and Western Europe, KSHV seroprevalence in adult general population or blood donors ranges from 0% to 8% (Challine et al, 2001;de Sanjose et al, 2002;Gambus et al, 2001;Gao et al, 1996b;Goedert et al, 1998;Lennette et al, 1996;Simpson et al, 1996). In these countries, the seroprevalence of KSHV in different risk groups mirrors the incidence of AIDS-KS, with a seroprevalence rate of between 25% and 50% among homosexual men.…”

Section: B Kshv Epidemiologymentioning

confidence: 99%

The Viral Etiology of AIDS‐Associated Malignancies

Angeletti

Zhang

Wood

2008

Advances in Pharmacology

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Seroprevalence of human herpes virus 8 antibody in populations at high or low risk of transfusion, graft, or sexual transmission of viruses

Cited by 51 publications

References 27 publications

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Risk factors for Kaposi's sarcoma among HHV‐8 seropositive homosexual men with AIDS

The Viral Etiology of AIDS‐Associated Malignancies

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