Serotonergic perturbations in dystonia disorders—a systematic review

Smit, Marije; Bartels, Anna L.; Faassen, Martijn van; Kuiper, Anouk; Niezen-Koning, Klary E.; Kema, IP; Dierckx, Rudi; Koning, Tom J. de; Tijssen, Marina A. J.

doi:10.1016/j.neubiorev.2016.03.015

Cited by 24 publications

(28 citation statements)

References 123 publications

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“…Dystonia (D) -is an involuntary movement disorder, often inherited, that occurs due to neuromediators disturbances. Different researchers reported changes in metabolism of biogenic amines, most important mediators, and those reports are very contradictory [1][2][3][4][5][6][7][8][9][10][11][12][13]. In our first personal studies we revealed tendency to enhancement of the level of Noradrenaline, Hidroxyindolacetic acid and Serotonin in D [14][15][16].…”

Section: Introductionmentioning

confidence: 95%

Analysis of Biogenic Amines Exchange in Dystonia

Belenky¹,

Vladimir²,

Koroleva³

et al. 2018

J Med - Clin Res & Rev

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Dystonia-is the debilitating movement disorder of central nervous system often inherited, appearing as involuntary movements, which occur due to deficiency or excess of neurotransmitters, mainly biogenic amines, such as dopamine, noradrenalin, and serotonin. The exact cause has been unveiled only in few forms of dystonia, such as dopa-responsive dystonia, where dopamine deficiency has been established, while the cause of most others forms of dystonia remaining obscure. Numerous studies of these forms have detected neurotransmitters disturbance, but those reports are very contradictory. In present study we explore the latent factors unifying some biogenic amines together into clusters bearing common certain functional mission in norm and in pathologic states such as dystonia. We compare the results obtained in dystonia group and in control of group of patients observed for suspicion for neuroglial tumors and we established that latent factors, unifying groups of biogenic amines, differ between the D group and the control group. We also have compared these two groups by means of discriminative analysis and As a result of discriminate analysis we derived equations of canonical linear discriminate (classification) functions (LCF) that probably can detect or exclude dystonia at examination of latent forms or "formes frustes" of this disorder. We expect to get even much more evident result by recruiting healthy control and by widening the spectre of biogenic amines measured.

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Section: Introductionmentioning

confidence: 95%

Analysis of Biogenic Amines Exchange in Dystonia

Belenky¹,

Vladimir²,

Koroleva³

et al. 2018

J Med - Clin Res & Rev

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“…Currently, it is not frequently used because of significant side effects due to effects on other neurotransmitter systems such as serotonin and norepinephrine 13. As suggested in a recent review, an SSRI to raise serotonin levels might be effective in CD 12. We hypothesised that escitalopram would reduce tremor and jerks and dystonic and psychiatric symptoms in patients with CD.…”

Section: Introductionmentioning

confidence: 97%

“…Neurotransmitter imbalance (especially increased levels of dopamine and decreased levels of serotonin) has been suggested to play a role in the pathophysiology of dystonia 12. Medication restoring this balance might be useful in treating all symptoms of CD, including the psychiatric symptoms 12.…”

Section: Introductionmentioning

confidence: 99%

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Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor

Zoons

Booij

Delnooz

et al. 2018

J Neurol Neurosurg Psychiatry

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“…Further evidence that alterations of the serotonergic system may play a role in the pathogenesis of dystonia, including CD, can be inferred from case reports describing dystonia induced by selective serotonin reuptake inhibitors. Also, in children with dopa-responsive dystonia as well as in adults with idiopathic adult-onset dystonia decreased levels of serotonin metabolites in cerebrospinal fluid have been reported ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Relationships between Serotonin Transporter Binding in the Raphe Nuclei, Basal Ganglia, and Hippocampus with Clinical Symptoms in Cervical Dystonia: A [11C]DASB Positron Emission Tomography Study

et al. 2018

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PurposeAlterations of the central serotonergic system have been implicated in the pathophysiology of dystonia. In this molecular imaging study, we assessed whether altered presynaptic serotonin transporter (SERT) binding contributes to the pathophysiology of cervical dystonia (CD), concerning both motor and non-motor symptoms (NMS).MethodsWe assessed the non-displaceable binding potential (BPND) using the selective SERT tracer [11C]DASB and positron emission tomography (PET) in 14 CD patients and 12 age- and gender-matched controls. Severity of motor symptoms was scored using the Toronto Western Spasmodic Torticollis Rating Scale and Clinical Global Impression jerks/tremor scale. NMS for depressive symptoms, anxiety, fatigue, and sleep disturbances were assessed with quantitative rating scales. The relationship between SERT binding and clinical patient characteristics was analyzed with the Spearman’s rho test and multiple regression.ResultsWhen comparing the CD patients with controls, no significant differences in BPND were found. Higher BPND in the dorsal raphe nucleus was statistically significantly correlated (p < 0.001) with motor symptom severity (rs = 0.65), pain (rs = 0.73), and sleep disturbances (rs = 0.73), with motor symptom severity being the most important predictor of SERT binding. Furthermore, fatigue was negatively associated with the BPND in the medial raphe nucleus (rs = −0.61, p = 0.045), and sleep disorders were positively associated with the BPND in the caudate nucleus (rs = 0.58, p = 0.03) and the hippocampus (rs = 0.56, p = 0.02).ConclusionMotor symptoms, as well as pain, sleep disturbances, and fatigue in CD showed a significant relationship with SERT binding in the raphe nuclei. Moreover, fatigue showed a significant relationship with the medial raphe nucleus and sleep disorders with the caudate nucleus and hippocampus. These findings suggest that an altered serotonergic signaling in different brain areas in CD is related to different motor as well as NMS, which will further stimulate research on the role of serotonin in the pathogenesis of dystonia.

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Serotonergic perturbations in dystonia disorders—a systematic review

Cited by 24 publications

References 123 publications

Analysis of Biogenic Amines Exchange in Dystonia

Analysis of Biogenic Amines Exchange in Dystonia

Randomised controlled trial of escitalopram for cervical dystonia with dystonic jerks/tremor

Relationships between Serotonin Transporter Binding in the Raphe Nuclei, Basal Ganglia, and Hippocampus with Clinical Symptoms in Cervical Dystonia: A [11C]DASB Positron Emission Tomography Study

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