Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activity

Clissold, Kara A.; Choi, Eugene; Pratt, Wayne E.

doi:10.1016/j.pbb.2013.10.002

Cited by 40 publications

(28 citation statements)

References 58 publications

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“…The frontal cortex shows a very high density of 5HT receptors and is important for memory functions, emotional behavior, attention and introspective processing (Hahn et al 2012). 5HT1A inhibition additionally decreased FC within the thalamic, caudate putamen, somatosensory and nucleus accumbens networks, consistent with the known involvement of serotonin in motor activity, sensory gating, and motivated behavior (Bishop et al 2009;Clissold et al 2013;van den Buuse 2013). When comparing the effect of cholinergic and serotonergic modulation, the frontal and thalamic networks were more affected by the latter.…”

Section: Discussionmentioning

confidence: 78%

Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain

et al. 2015

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Resting-state functional MRI (rsfMRI) is a widely implemented technique used to investigate large-scale topology in the human brain during health and disease. Studies in mice provide additional advantages, including the possibility to flexibly modulate the brain by pharmacological or genetic manipulations in combination with high-throughput functional connectivity (FC) investigations. Pharmacological modulations that target specific neurotransmitter systems, partly mimicking the effect of pathological events, could allow discriminating the effect of specific systems on functional network disruptions. The current study investigated the effect of cholinergic and serotonergic antagonists on large-scale brain networks in mice. The cholinergic system is involved in cognitive functions and is impaired in, e.g., Alzheimer's disease, while the serotonergic system is involved in emotional and introspective functions and is impaired in, e.g., Alzheimer's disease, depression and autism. Specific interest goes to the default-mode-network (DMN), which is studied extensively in humans and is affected in many neurological disorders. The results show that both cholinergic and serotonergic antagonists impaired the mouse DMN-like network similarly, except that cholinergic modulation additionally affected the retrosplenial cortex. This suggests that both neurotransmitter systems are involved in maintaining integrity of FC within the DMN-like network in mice. Cholinergic and serotonergic modulations also affected other functional networks, however, serotonergic modulation impaired the frontal and thalamus networks more extensively. In conclusion, this study demonstrates the utility of pharmacological rsfMRI in animal models to provide insights into the role of specific neurotransmitter systems on functional networks in neurological disorders.

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Section: Discussionmentioning

confidence: 78%

Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain

et al. 2015

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“…However, the specific function of the 5-HT7-receptor in cognitive processes remains largely unknown, except for a role in memory formation, sleep, and psychiatric disorders 45 . Activation of 5-HT7 receptors in rat ventral striatum decreased ambulatory activity but had no effects on reward-related behaviour 46 . On balance, we therefore believe that it is unlikely that the present effects of amisulpride were mediated by 5-HT7…”

Section: Discussionmentioning

confidence: 90%

The dopaminergic reward system underpins gender differences in social preferences

et al. 2017

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“…The primary mode of action of SSRI is blockade of serotonin (5-HT) re-uptake into the pre-synaptic nerve ending, causing an elevated concentration of serotonin in the synaptic cleft. Serotonin is involved in a vast array of systems in the body and is known to affect satiety (Grignaschi et al, 1998;Ward et al, 1999), mood parameters such as aggression (Ricci and Melloni, 2012) and locomotor activity (Clissold et al, 2013;Olsén et al, 2014). In humans, sexual dysfunction is a common result of elevated serotonin levels (Keltner et al, n.d.) and suppressed serotonin levels cause clinical depression (Van Praag, 1977).…”

Section: Introductionmentioning

confidence: 99%

Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus)

et al. 2015

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PostprintThis is the accepted version of a paper published in Aquatic Toxicology. This paper has been peerreviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the original published paper (version of record):Kellner, M., Porseryd, T., Porsch-Hallstrom, I., Hansen, S., Olsén, H. (2015) Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus).Aquatic Toxicology,[158][159][160][161][162][163][164][165][166][167][168][169][170] http://dx.doi.org/10.1016/j.aquatox. 2014.11.003 Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. NOTICE: this is the author's version of a work that was accepted for publication in Aquatic Toxicology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Aquatic Toxicology, Vol. 158,[165][166][167][168][169][170] Abstract Selective Serotonin Re-uptake Inhibitors (SSRI) are mood-altering, psychotropic drugs commonly used in the treatment of depression and other psychological illnesses. Many of them are poorly degraded in sewage treatment plants and enter the environment unaltered. In laboratory studies, they have been demonstrated to affect a wide range of behaviours in aquatic organisms. In this study we investigated the effect of a three week exposure of 0.15 and 1.5 µg/l of the SSRI citalopram dissolved in the ambient water on the feeding behaviour in three-spine stickleback (Gasterosteus aculeatus). Feeding, measured as the number of attacks performed on a piece of frozen bloodworms during a 10 minute period, was reduced by 40-60% in fish exposed to both 0.15 and 1.5 µg/l citalopram. The effects of the environmentally relevant dose 0.15 µg/l on feeding, an important fitness characteristic, suggests that the ecological significance of environmental SSRI exposure may be pronounced.

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Serotonin 1A, 1B, and 7 receptors of the rat medial nucleus accumbens differentially regulate feeding, water intake, and locomotor activity

Cited by 40 publications

References 58 publications

Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain

Cholinergic and serotonergic modulations differentially affect large-scale functional networks in the mouse brain

The dopaminergic reward system underpins gender differences in social preferences

Environmentally relevant concentrations of citalopram partially inhibit feeding in the three-spine stickleback (Gasterosteus aculeatus)

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