Serotonin and serotonin-immunoreactive neurons in the nervous system of insects

Nässel, Dick R.

doi:10.1016/0301-0082(88)90002-0

Cited by 229 publications

(111 citation statements)

References 297 publications

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“…2). For histamine the strongest signal appeared in the visual system (Pollack and Hofbauer, 1991), which also showed a strong signal for 5-HT (Nässel, 1987). Dopamine showed very little labeling in the optic lobe, however, as previously reported (Nässel et al, 1988), for which reason we compared immunolabeling to this amine in the region of the central brain of frontal sections.…”

Section: Mutants Have Reduced Immunoreactivities To Histamine and Cspmentioning

confidence: 59%

DrosophilaABC transporter mutantswhite,brownandscarlethave altered contents and distribution of biogenic amines in the brain

Borycz

Kubów

Lloyd

et al. 2008

Journal of Experimental Biology

149

169

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SUMMARYMonoamines such as dopamine, histamine and serotonin (5-HT) are widely distributed throughout the brain of the fruit fly Drosophila melanogaster, where many of their actions have been investigated. For example, histamine is released from photoreceptor synapses in the lamina neuropile of the visual system. Mutations of the genes white, an important eye pigmentation marker in fly genetics that encodes an ABC transporter, and its binding partner brown, cause neural phenotypes not readily reconciled solely with actions in eye pigmentation. We find that flies mutant for these genes, and another binding partner, scarlet, have about half the wild-type amount of histamine in the head, as well as reduced 5-HT and dopamine. These differences parallel reductions in immunoreactivity to the corresponding biogenic amines. They also correlate with the amine content of fractions after differential centrifugation of head homogenates. Thus, most of the amine is found in the vesicle-rich fraction of wild-type head homogenates, whereas it is found in the supernatant fractions from white, brown and scarlet flies. White co-expresses in lamina epithelial glia with Ebony, which conjugates histamine to β-alanine. Histamine is then released when the conjugate is hydrolyzed in photoreceptors, by Tan. Mutant white ameliorates the effects of tan on head histamine whereas it exacerbates the effects of ebony. Our results are consistent with the proposal that histamine uptake by the epithelial glia may be white dependent. Behavioral abnormalities in white, brown and scarlet mutants could arise because aminergic neurons in the Drosophila brain have reduced amine for release.

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Section: Mutants Have Reduced Immunoreactivities To Histamine and Cspmentioning

confidence: 59%

DrosophilaABC transporter mutantswhite,brownandscarlethave altered contents and distribution of biogenic amines in the brain

Borycz

Kubów

Lloyd

et al. 2008

Journal of Experimental Biology

149

169

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“…Serotonin (5-hydroxytryptamine, 5-HT), a biogenic amine that can act as a neurotransmitter, neuromodulator, or as a neurohormone (Edwards and Kravitz, 1997;Nässel, 1987), is found in widely branching neurons in the insect brain, some supplying the mushroom bodies (Schürmann and Klemm, 1984;Homberg and Hildebrand, 1989;Dacks et al, 2006). Evidence suggests that it may influence olfactory learning in honey bees (Mercer and Menzel, 1982) and modulate the sensitivity and excitability of projection neurons in the antennal lobes of the moth Manduca sexta (Mercer et al, 1995;Kloppenburg et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Global and local modulatory supply to the mushroom bodies of the moth Spodoptera littoralis

Sinakevitch¹,

Sjöholm

Hansson

et al. 2008

Arthropod Structure & Development

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The moth Spodoptera littoralis, is a major pest of agriculture whose olfactory system is tuned to odorants emitted by host plants and conspecifics. As in other insects, the paired mushroom bodies are thought to play pivotal roles in behaviors that are elicited by contextual and multisensory signals, amongst which those of specific odors dominate. Compared with species that have elaborate behavioral repertoires, such as the honey bee Apis mellifera or the cockroach Periplaneta americana, the mushroom bodies of S. littoralis were originally viewed as having a simple cellular organization. This has been since challenged by observations of putative transmitters and neuromodulators. As revealed by immunocytology, the spodopteran mushroom bodies like those of other taxa, are subdivided longitudinally into discrete neuropil domains. Such divisions are further supported by the present study, which also demonstrates discrete affinities to different mushroom body neuropils by antibodies raised against two putative transmitters, glutamate and γ-aminobutyric acid, and against three putative neuromodulatory substances: serotonin, A-type allatostatin, and tachykinin-related peptides. The results suggest that in addition to longitudinal divisions of the lobes, circuits in the calyces and lobes are likely to be independently modulated.

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“…Some neuropils of the insect brain, such as the OL (Nässel, 1988), CC (Homberg, 1991), AL (Rehder et al, 1987) and MBs (Homberg et al, 1989), show dense immunoreactivity, indicating an important role of 5-HT in these neuropils. The functional properties of biogenic amines in insect brains still need to be investigated further: individual neurons containing particular biogenic amines should be examined in detail physiologically and morphologically, and their target neurons should be identified.…”

Section: Presumptive Roles Of Serotonin-immunoreactive Neurons In Thementioning

confidence: 99%

“…(Mercer and Menzel, 1982;Blenau and Erber, 1998;Robinson et al, 1999;Wagener-Hulme et al, 1999;Schulz and Robinson, 2001;Schulz et al, 2003). Serotonin is particularly widespread in the insect brain, and immunocytochemical studies suggest that serotoninimmunoreactive neurons play different roles in functionally discrete neuropils of insect brains (Rehder et al, 1987;Salecker and Distler, 1990;Homberg, 1991;Sun et al, 1993;Nässel, 1988;Iwano and Kanzaki R, 2005;Dacks et al, 2006). Serotonin enhances responsiveness in AL glomeruli and behavioral responses to pheromone in Bombyx (Hill et al, 2003;Gatellier et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Serotonin-immunoreactive Neurons in the Antennal Sensory System of the Brain in the Carpenter Ant, Camponotus japonicus

et al. 2007

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Serotonin and serotonin-immunoreactive neurons in the nervous system of insects

Cited by 229 publications

References 297 publications

DrosophilaABC transporter mutantswhite,brownandscarlethave altered contents and distribution of biogenic amines in the brain

DrosophilaABC transporter mutantswhite,brownandscarlethave altered contents and distribution of biogenic amines in the brain

Global and local modulatory supply to the mushroom bodies of the moth Spodoptera littoralis

Serotonin-immunoreactive Neurons in the Antennal Sensory System of the Brain in the Carpenter Ant, Camponotus japonicus

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