Serotonin-induced paw edema in the rat: Pharmacological profile

Cole, Harlan W.; Brown, Charles Eric; Magee, David E.; Magee, Christopher; Roudebush, Roger E.; Bryant, Henry U.

doi:10.1016/0306-3623(94)00180-u

Cited by 14 publications

(15 citation statements)

References 15 publications

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“…The paw volume started to increase beginning at 0 hr and continued up to 1 hr before it gradually decreased. Similar study conducted by Cole et al [17] also showed a significant increase of paw edema volume at the first hour ( P < 0.05) after injection of serotonin. AEBO at doses of 50 and 150 mg/kg effectively suppressed the edema and demolished the peak at 1 hr following serotonin injection.…”

Section: Discussionsupporting

confidence: 85%

“…Among the several methods of acute inflammation, the carrageenan-induced inflammatory response which was described in 1962 [17] in the rat paw has been well established as a valid model to study acute inflammation. To ascertain the effect of the AEBO, serotonin (inflammatory mediator agent) was used as oedemogen [19].…”

Section: Discussionmentioning

confidence: 99%

“…Acute inflammation was produced by the subplantar injection of 0.1 mL of 0.2 mg/mL concentration [17] of serotonin in distilled water into the footpad [18]. The AEBO at 50 and 150 mg/kg was given orally for four days and 60 min before serotonin injection on the fourth day.…”

Section: Methodsmentioning

confidence: 99%

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Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration byBixa orellanaLeaf Extract

Yong

Sulaiman

Hakim

et al. 2013

BioMed Research International

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The aim of the present study was to evaluate the anti-inflammatory activities of aqueous extract of Bixa orellana (AEBO) leaves and its possible mechanisms in animal models. The anti-inflammatory activity of the extract was evaluated using serotonin-induced rat paw edema, increased peritoneal vascular permeability, and leukocyte infiltrations in an air-pouch model. Nitric oxide (NO), indicated by the sum of nitrites and nitrates, and vascular growth endothelial growth factor (VEGF) were measured in paw tissues of rats to determine their involvement in the regulation of increased permeability. Pretreatments with AEBO (50 and 150 mg kg−1) prior to serotonin inductions resulted in maximum inhibitions of 56.2% of paw volume, 45.7% of Evans blue dye leakage in the peritoneal vascular permeability model, and 83.9% of leukocyte infiltration in the air-pouch model. 57.2% maximum inhibition of NO and 27% of VEGF formations in rats' paws were observed with AEBO at the dose of 150 mg kg−1. Pharmacological screening of the extract showed significant (P < 0.05) anti-inflammatory activity, indicated by the suppressions of increased vascular permeability and leukocyte infiltration. The inhibitions of these inflammatory events are probably mediated via inhibition of NO and VEGF formation and release.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration byBixa orellanaLeaf Extract

Yong

Sulaiman

Hakim

et al. 2013

BioMed Research International

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“…Besides, it has been reported that development of carrageenan-induced edema (Khaksari et al, 1999) and skin inflammation (De Vries et al, 1995) in rats, as well as serotonin-induced paw edema in mice (Cole et al, 1995) were blunted by Ca 2+ antagonist. Con A induces a rapid initial increase in intracellular concentration of Ca 2+ and successive Ca 2+ influx through Ca 2+ channels (Ikegami et al, 1991).…”

Section: Discussionmentioning

confidence: 97%

Strain differences in concanavalin a-induced paw edema in the rat: Involvement of histamine H1 and H2 receptors

Kuštrimović¹,

Mitić²,

Dimitrijević³

et al. 2011

Acta vet. (Beogr.)

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The present study tests the hypothesis that the difference in the intensity of paw edema found between the Dark Agouti (DA) and Albino Oxford (AO) rat strains originates from the distinct participation of histamine, serotonin and their corresponding receptors in Concanavalin A (Con A)-induced inflammation. DA and AO male rats were intraplantarly injected with specific receptor antagonists prior to Con A, and the intensity of inflammation was determined by measuring the paw diameter. Our results have showed that histamine H1 and H2 receptor antagonists reduced the Con A-induced paw edema in DA rats, while serotonin 5HT3 receptor antagonist diminished the inflammation in both DA and AO rat strains. The calcium channel blocker did not change Con A-induced inflammation. Strain differences in the intensity and kinetics of inflammation observed between the DA and AO rats are most likely defined by the diversity of mediators released and their receptors activated upon Con A injection

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“…Each endpoint was taken as the time as peak response of hind paw oedema induced by PAF and histamine. Since serotonin is known to induce a linear increase in the paw oedema within 1 h, the endpoint was taken as 30 min after the injection (Cole et al, 1995).…”

Section: Time-resolved Fluorometric Assaymentioning

confidence: 99%

C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo

Sato

Yamanaka

et al. 2014

European Journal of Pharmacology

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Serotonin-induced paw edema in the rat: Pharmacological profile

Cited by 14 publications

References 15 publications

Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration byBixa orellanaLeaf Extract

Suppressions of Serotonin-Induced Increased Vascular Permeability and Leukocyte Infiltration byBixa orellanaLeaf Extract

Strain differences in concanavalin a-induced paw edema in the rat: Involvement of histamine H1 and H2 receptors

C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo

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