C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo

Sato, Akira; Oe, Keitaro; Yamanaka, Hikaru; Yokoyama, Izumi; Ebina, Keiichi

doi:10.1016/j.ejphar.2014.10.020

Cited by 8 publications

(4 citation statements)

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“…The use of proteins as biomarkers for systemic inflammatory response is well established, with CRP being prominent due to its ease of acquisition, cost-effectiveness, and extensive literature support 19 , 20 . CRP levels can rise rapidly in response to acute inflammatory conditions 21 .…”

Section: Discussionmentioning

confidence: 99%

Effects of curcumin supplementation on abdominal surgical wound healing

Santos,

Campos,

Gonçalves Junior

et al. 2024

Acta Cir. Bras.

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Purpose: To evaluate the effects of curcumin supplementation on abdominal surgical wound healing in rats using clinical, histological, and hematological parameters. Methods: Forty Wistar rats were randomly divided into two groups: the curcumin group, and the control group. The curcumin group received, in addition to water and standard feed, curcumin via gavage at the dose of 200 mg/kg for seven days preceding and seven days following surgery. The control group received only water and standard feed. Both groups underwent median laparotomy and left colotomy. On the eighth postoperative day, the groups were euthanized, and the left colon was resected for histological analysis. Results: In the preoperative evaluation, there was a significant decrease in the mean C-reactive protein levels in the curcumin group (0.06) compared to the control group (0.112) (p = 0.0001). In the postoperative wound healing assessment, a significant decrease was observed in inflammatory infiltrate (p = 0.0006) and blood vessel count (p = 0.0002) in the curcumin group compared to the control group. Conclusions: Curcumin supplementation was able to significantly reduce inflammatory parameters in both pre-and post-operative phases of abdominal surgical wounds in rats.

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Section: Discussionmentioning

confidence: 99%

Effects of curcumin supplementation on abdominal surgical wound healing

Santos,

Campos,

Gonçalves Junior

et al. 2024

Acta Cir. Bras.

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“…Early studies found CRP inhibits PAF‐induced platelet aggregation suggesting CRP may act as an early protective anti‐inflammatory mechanism in acute inflammation 113 . However, CRP enhances PAF‐induced inflammatory activity through binding to PAF 114 and recent research found a significant positive correlation between PAF and CRP and concluded that although hsCRP was a valuable diagnostic marker for coronary atherosclerosis, PAF was a better prognostic indicator for coronary atherosclerosis 73 …”

Section: Discussionmentioning

confidence: 99%

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

et al. 2022

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Traditionally cardiovascular disease (CVD) risk has been assessed through blood lipids and inflammatory marker C-reactive protein (hsCRP). Recent clinical interest in novel pro-inflammatory markers platelet-activating factor (PAF) and lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) recognizes that vascular damage can exist in the absence of traditional risk factors. This crosssectional study investigated the potential relationship between circulating PAF, Lp-PLA 2 , hsCRP, and traditional risk factors for CVD. One hundred adults (49 ± 13 years, 31% male) with variable CVD risk were recruited. Fasting inflammatory markers PAF, Lp-PLA 2 and hsCRP and total, high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol, and triglycerides were measured. Blood pressure, body mass index, and waist circumference were measured. Medical and physical activity data were self-reported. Linear and multiple regressions were performed. PAF, Lp-PLA 2 , and hsCRP independently correlated with several CVD risk factors. PAF was correlated significantly with risk factors in an unexpected way; there was a medium positive correlation between PAF and HDL cholesterol (r = 0.394, p < 0.001) and medium negative correlations with Total:HDL cholesterol; (r = À0.436, p < 0.001) systolic blood pressure; (r = À0.307, p = 0.001); BMI (r = À0.381, p < 0.001); and waist circumference (r = À0.404, p < 0.001). There were large positive correlations between Lp-PLA 2 and LDL (r = 0.525, p < 0.001) and non-HDL cholesterol (r = 0.508, p < 0.001). There were large positive correlations between hsCRP and Total:HDL cholesterol (r = 0.524, p < 0.001); BMI

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“…CRP is an acute phase inflammatory marker that increases rapidly and dramatically in response to acute inflammation [ 37 ]. It has been shown that CRP can enhance the platelet-activating factor (PAF)-induced inflammation via binding to PAF and its precursor [ 38 ]. One of our key findings is that AIRME received rats exhibited lower levels of CRP as well as decreased WBC and platelet count, which implies potent anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro and In Vivo Studies

et al. 2021

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In our in vitro and in vivo studies, we used Acalypha indica root methanolic extract (AIRME), and investigated their free radical scavenging/antioxidant and anti-inflammatory properties. Primarily, phytochemical analysis showed rich content of phenols (70.92 mg of gallic acid/g) and flavonoids (16.01 mg of rutin/g) in AIRME. We then performed HR-LC-MS and GC-MS analyses, and identified 101 and 14 phytochemical compounds, respectively. Among them, ramipril glucuronide (1.563%), antimycin A (1.324%), swietenine (1.134%), quinone (1.152%), oxprenolol (1.118%), choline (0.847%), bumetanide (0.847%) and fenofibrate (0.711%) are the predominant phytomolecules. Evidence from in vitro studies revealed that AIRME scavenges DPPH and hydroxyl radicals in a concentration dependent manner (10–50 μg/mL). Similarly, hydrogen peroxide and lipid peroxidation were also remarkably inhibited by AIRME as concentration increases (20–100 μg/mL). In vitro antioxidant activity of AIRME was comparable to ascorbic acid treatment. For in vivo studies, carrageenan (1%, sub-plantar) was injected to rats to induce localized inflammation. Acute inflammation was represented by paw-edema, and significantly elevated (p < 0.05) WBC, platelets and C-reactive protein (CRP). However, AIRME pretreatment (150/300 mg/kg bodyweight) significantly (p < 0.05) decreased edema volume. This was accompanied by a significant (p < 0.05) reduction of WBC, platelets and CRP with both doses of AIRME. The decreased activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase in paw tissue were restored (p < 0.05 / p < 0.01) with AIRME in a dose-dependent manner. Furthermore, AIRME attenuated carrageenan-induced neutrophil infiltrations and vascular dilation in paw tissue. For the first time, our findings demonstrated the potent antioxidant and anti-inflammatory properties of AIRME, which could be considered to develop novel anti-inflammatory drugs.

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C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo

Cited by 8 publications

References 50 publications

Effects of curcumin supplementation on abdominal surgical wound healing

Effects of curcumin supplementation on abdominal surgical wound healing

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors

Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro and In Vivo Studies

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C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo

Cited by 8 publications

References 50 publications

Effects of curcumin supplementation on abdominal surgical wound healing

Effects of curcumin supplementation on abdominal surgical wound healing

Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A2 activity and traditional cardiovascular risk factors

Phytochemical Profile, Free Radical Scavenging and Anti-Inflammatory Properties of Acalypha Indica Root Extract: Evidence from In Vitro and In Vivo Studies

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Product

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Interrelationships among platelet‐activating factor and lipoprotein‐associated phospholipase A₂ activity and traditional cardiovascular risk factors