SERS spectroscopy for detection of hydrogen cyanide in breath from children colonised with P. aeruginosa

Lauridsen, Rikke Kragh; Skou, Peter Bæk; Rindzevicius, Tomas; Wu, Kaiyu; Molin, Søren; Engelsen, Søren Balling; Nielsen, Kim G.; Johansen, Helle Krogh; Boisen, Anja

doi:10.1039/c7ay01693j

Cited by 7 publications

(1 citation statement)

References 21 publications

(26 reference statements)

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“…The SERS detection of volatile organic compounds (VOCs) biomarkers in human breath, such as acetone in the case of diabetes or hydrogen cyanide in patients with cystic fibrosis, is gaining of importance as non-invasive tool in primary screening diagnosis. The group of Boisen detected 5ppmV of hydrogen cyanide in gas phase [4] and later on P. aeruginosa cultures [5]. The term of plasmonic nose was recently coined for a SERS substrate that consists on a core-shell structure of Ag nanocubes encapsulated in porous metal organic framework MOF, in particular ZIF-8 [6].…”

Section: Introductionmentioning

confidence: 99%

Gas phase detection of chemical warfare agents CWAs with portable Raman

Lafuente

Sanz

Urbiztondo

et al. 2020

Journal of Hazardous Materials

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The development of SERS substrates for chemical detection of specific analytes requires appropriate selection of plasmonic metal and the surface where it is deposited.Here we deposited Ag nanoplates on three substrates: i) conventional SiO 2 /Si wafer, ii) stainless steel mesh and iii) graphite foils. The SERS enhancement of the signal was studied for Rhodamine 6G (R6G) as common liquid phase probe molecule. We conducted a comprehensive study with =532, 633 and 785 nm on all the substrates.The best substrate was investigated, at the optimum laser 785 nm, for gas phase detection of dimethyl methyl phosphonate (DMMP), simulant of the G-series nerve agents, at a concentration of 2.5 ppmV (14 mg/m 3 ). The spectral fingerprint was clearly observed; with variations on the relative intensities of SERS Raman bands compared to bulk DMMP in liquid phase reflects the DMMP-Ag interactions. These interactions were simulated by Density Functional Theory (DFT) calculations and the simulated spectra matched with the experimental one. Finally, we were detected the characteristics DMMP fingerprint with hand-held portable equipment. These results open the way for the application of SERS technique on real scenarios where robust, light-weight, miniaturized and simple to use and cost-effective tools are required by first responders.

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Section: Introductionmentioning

confidence: 99%