Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Bai, Yuanyuan; Yang, Rui; Song, Yanan; Wang, Yuhuan

doi:10.1055/s-0043-122142

Cited by 10 publications

(6 citation statements)

References 17 publications

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“…Previous research revealed that UA is related to serum 1,5‐AG in both the diabetic and nondiabetic population . Our research group also found that the values of 1,5‐AG had positive correlations to UA independently ( P < 0.01).…”

Section: Discussionsupporting

confidence: 80%

“…Levels of 1,5-AG decreased when the kidneys were slightly impaired (eGFR 30-59 mL/min) or during ultrafiltration. Other research 31,39 has indicated that eGFR is not a determinant for 1,5-AG during slight to moderate renal impairment (eGFR >30 mL/min/1.73 m 2 ). Each participant of this study had an eGFR larger than 30 mL/ min/1.73 m 2 , ranging from 42.4 to 153.1 mL/ min/1.73 m 2 .…”

Section: Discussionmentioning

confidence: 94%

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Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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Background: Serum 1,5-anhydroglucitol (1,5-AG) is a new glycemic marker which can reflect glucose fluctuation over 3 to 7 days and is now increasingly used to monitor glucose control and to screen for diabetes. However, 1,5-AG has not been widely used in China due to lack of epidemiological support. Our study aims to establish the reference intervals for a population with normal glucose tolerance in Jiangsu Province and to explore the determinants of these intervals. Method:The study enrolled 646 healthy adults aged 20 to 70 years in Jiangsu Province in 2018 after oral glucose tolerance test. 1,5-AG, fasting and 2-hour glucose, UA, liver enzyme, serum lipid, creatinine, and glycosylated hemoglobin were measured. We calculated reference intervals using the parametric method and examined the relationship between 1,5-AG and influence factors.Results: The average age of the participants was 50.5 ± 9.0 years, and 69.5% of them were females. The reference intervals were 15.8 to 52.6 μg/mL for males and 14.3 to 48.0 μg/mL for females. Among females, the reference intervals were 13.9 to 45.3 and 14.6 to 49.6 μg/mL for menopausal and postmenopausal females, respectively. Males showed higher 1,5-AG concentrations than females, and postmenopausal females had higher 1,5-AG than menopausal females. There was a positive correlation between uric acid and 1,5-AG in both genders. Positive correlation between 1,5-AG and age was only observed in females. Conclusion:We established reference intervals for 1,5-AG in Jiangsu Province, and the level of 1,5-AG is affected by sex, uric acid, and age. Highlights• Males, menopausal females, and postmenopausal females had corresponding reference intervals for 1,5-anhydroglucitol (1,5-AG). • Levels of serum uric acid and age should be taken into consideration when interpreting 1,5-AG.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 94%

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Chen

Wang

Tan

et al. 2020

Journal of Diabetes

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“…In the present study, the subjects were classified into different groups by eGFR, and we found that 1,5-AG was still negatively associated with HbA1c in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m 2 . Considering these results, we conclude that 1,5-AG remain a reliable glycemic control marker even if patients suffer mild or moderate renal dysfunction, which is consistent with a previous observation [35]. In addition, in the current study, we showed that serum 1,5-AG levels were not influenced by eGFR, whereas a previous study reported that 1,5-AG was negatively correlated with kidney function, which might be owing to an age-associated decrease in the renal glucose threshold [28].…”

Section: Discussionsupporting

confidence: 92%

Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Zhang

Xue

Yuan

et al. 2019

International Journal of Endocrinology

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Aim. Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions. Methods. A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Patients’ clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured. Correlation analyses were carried out to analyze their correlation with serum 1,5-AG and SUA. Results. The male group showed higher levels of SUA than the female group (282.1 ± 91.2 and 244.7 ± 71.89 μmol/L, respectively, P<0.01). Pearson’s correlation coefficients determine that SUA was positively associated with 1,5-AG in both men (r=0.213, P<0.05) and women (r=0.223, P<0.05), and such relationship can be influenced by the renal function. The positive association still existed with moderate impaired renal function. Moreover, 1,5-AG had a negative association with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m2 (P<0.01). Conclusion. The positive association between SUA and 1,5-AG still exists in T2DM with moderate renal failure. 1,5-AG can still reflect the glucose levels in patients with CKD stages 1-3.

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“…Several recent clinical studies have demonstrated that low serum 1,5-AG levels are a strong indicator of cardiovascular disease in patients not undergoing HD, suggesting that 1,5-AG is involved in the development of this disorder [ 2 , 13 , 14 , 20 ]. Nevertheless, the mechanisms by which serum 1,5-AG levels are decreased other than poor renal reabsorption have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis

Tanaka¹,

Sakasai-Sakai

Motomiya³

et al. 2021

Diabetol Metab Syndr

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Background 1,5-anhydroglucitol is a reduction product of 1,5-anhydrofructose. Circulating 1,5-anhydroglucitol is usually excreted by the kidneys and is reabsorbed via sodium-glucose co-transporter 4 in the renal tubules. In patients on hemodialysis, serum levels of 1,5-anhydroglucitol have been reported to be low; however, the underlying mechanism remains unclear. Methods We measured inter-dialysis changes in the levels of serum 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products (AGEs) in 78 patients on hemodialysis. Serum levels of 1,5-anhydrofructose-derived AGEs were also determined using a polyclonal antibody. Results The serum 1,5-anhydroglucitol level was decreased to as low as 2.0 μg/mL in the regular hemodialysis group; however, we could not verify changes in the serum 1,5-anhydroglucitol level during inter-dialysis days because of undetectable levels in 29 patients. The measured serum level of 1,5-anhydrofructose-derived AGEs was significantly increased in both patient groups. In addition, the 1,5-anhydrofructose-derived AGEs/1,5-anhydroglucitol ratio was higher in patients on hemodialysis than in controls. Conclusions Accelerated glycation of 1,5-anhydrofructose is one possible mechanism by which serum 1,5-anhydroglucitol levels are lowered in patients on HD, and we propose that the 1,5-anhydrofructose-derived AGEs/1,5-anhydroglucitol ratio should be measured in clinical settings in which patients have low serum levels of 1,5-AG.

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Serum 1,5-Anhydroglucitol Concentrations Remain Valid as a Glycemic Control Marker In Diabetes with Earlier Chronic Kidney Disease Stages

Abstract: 1,5-AG values remain reliable as a glycemic control marker In diabetes with mild or moderate dysfunction. Serum UA was significantly and positively correlated with 1,5-AG levels. HbA1c may be a good biomarker for insulin resistance compared with 1,5-AG and FMN.

Cited by 10 publications

References 17 publications

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Reference intervals for serum 1,5‐anhydroglucitol of a population with normal glucose tolerance in Jiangsu Province

Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis

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