Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men

Kazumi, Tsutomu; Kawaguchi, Akira T.; Hirano, Tsutomu; Yoshino, Gen

doi:10.1016/j.metabol.2003.12.008

Cited by 111 publications

(83 citation statements)

References 45 publications

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“…Furthermore, we corroborated the strong relationship previously described between adiponectin and HDLcholesterol [13,47,48]. HDL-cholesterol is an important predictor of endothelial function [49][50][51][52][53].…”

Section: Discussionsupporting

confidence: 90%

“…Our study demonstrates that in offspring of diabetic parents HDL-cholesterol correlates highly with adiponectin, an association previously reported in healthy [13,14], obese [47] and type 2 diabetic subjects [48]. The link between HDL-cholesterol and EDV that we demonstrate is well established: multiple studies show low HDLcholesterol is highly predictive of endothelial dysfunction in healthy and diabetic subjects [49][50][51][52][53], and in experimental models where HDL-cholesterol is raised acutely, EDV normalises [58].…”

Section: Discussionsupporting

confidence: 81%

“…Epidemiologically, serum levels of the protein correlate negatively with cardiac risk factors, positively with HDL-cholesterol and are lower in patients with coronary artery disease than in controls [13][14][15]. Adiponectin accumulates in rat carotid artery walls after balloon injury, but not in healthy vessel walls [16] and has been shown to suppress both the conversion of macrophages to foam cells and the migration of smooth muscle cells [6,17].…”

Section: Introductionmentioning

confidence: 99%

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The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes

et al. 2005

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Aims/hypothesis: Adiponectin is an adipokine with insulin-sensitising and anti-atherogenic properties. We studied the role played by total adiponectin and by the bioactive high-molecular-weight (HMW) oligomeric complexes of adiponectin in vascular function in offspring whose parents both had type 2 diabetes, a population at high risk of diabetes and atherosclerosis. Methods: Total and %HMW adiponectin, the cytokines C-reactive protein, interleukin-6 and plasminogen activator inhibitor-1 (PAI-1), as well as lipid profiles were assayed in 19 offspring, each with two type 2 diabetic parents. Subjects underwent OGTTs and IVGTTs. Endothelium-dependent vasodilation (EDV) was assessed by brachial artery ultrasonography. Results: There was a significant relationship between %HMW and total adiponectin levels (r=0.72, p=0.001). Despite an expected strong positive correlation between HDL-cholesterol and adiponectin levels (r=0.52, p=0.04), as well as HDL-cholesterol and EDV (r=0.56, p<0.02), there was no significant relationship between either total adiponectin or % HMW adiponectin and EDV. Adiponectin was inversely associated with PAI-1 (r=0.50, p=0.05), but did not correlate with the inflammatory markers C-reactive protein or interleukin-6. Conclusions/interpretation: In offspring of diabetic parents, a population at high risk of diabetes and atherosclerotic disease, there is no relationship between total or %HMW adiponectin and endotheliumdependent vasodilation. However, low adiponectin was associated with impaired fibrinolysis as manifested by increased levels of plasminogen activator inhibitor-1.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

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The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes

et al. 2005

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“…In men with abdominal obesity with blunted growth hormone secretion, growth hormone treatment marginally increased the mean LDL diameter (Svensson et al, 2000). Furthermore, serum adiponectin (Kazumi et al, 2004) and polymorphism of the beta3-adrenergic receptor gene (Okumura et al, 2003), which have been shown to be related to obesity and insulin sensitivity, were also associated with LDL particle size in healthy Japanese subjects.…”

Section: Discussionmentioning

confidence: 92%

LDL particle size, fat distribution and insulin resistance in obese children

et al. 2005

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Background: The importance of small dense low-density lipoprotein (sdLDL) cholesterol in coronary heart disease has been demonstrated in many studies. Body fat accumulation, especially abdominal adiposity, is one of the important factors modifying the expression of sdLDL in adults. Objective: To determine the prevalence of sdLDL in obese children, and to investigate its relationship with anthropometric and metabolic variables. Subjects: A total of 30 obese children (22 males, 8 females) aged 12.670.6 years (mean7s.e.), who presented to our outpatient clinic with obesity. Methods: LDL peak particle diameter was determined using gel electrophoresis. LDL subclasses were classified into sdLDL (pattern B; diametero25.5 nm) and non-sdLDL (pattern A; diameterX25.5 nm). Anthropometric and metabolic variables were also determined to identify factors modifying LDL particle size. Results: sdLDL was detected in 11 children (40.0%). In children with sdLDL, waist/height ratio was significantly higher (P ¼ 0.0466), and they had significantly higher triglyceride (TG) (P ¼ 0.0035) and lower high-density lipoprotein cholesterol (HDLC) levels (P ¼ 0.036). Peak LDL diameter as a continuous variable was significantly correlated with HDLC and TG levels. In multiple regression analysis, body mass index and waist/height ratio were significant determinants of the peak LDL diameter variability. Conclusions: We found a high prevalence of sdLDL in obese children, and a relationship of peak LDL diameter with abdominal fat accumulation, HDLC and TG levels. The presence of sdLDL might be an important risk factor for the metabolic syndrome.

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“…Adiponectin was shown to decrease hepatic glucose output and to enhance muscle fat oxidation and glucose transport. In man, adiponectin levels were shown to correlate negatively with BMI, C-reactive protein (CRP), and fasting level of glucose, insulin and triglycerides, and to correlate positively with high-density lipoprotein cholesterol (HDL-C) (10,14,15) Adiponectin levels are also significantly lower in patients with CAD than in control subjects (16), and adiponectin levels are inversely correlated with progression of coronary artery calcification in diabetic and nondiabetic patients (17). The antiatherogenic effects of adiponectin have been attributed partly to its anti-inflammatory properties (12).…”

Section: Introductionmentioning

confidence: 99%

Adiponectin and the development of diabetes in patients with coronary artery disease and impaired fasting glucose

Knobler¹,

Benderly²,

Boyko³

et al. 2006

eur j endocrinol

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Objectives: Adiponectin has insulin-sensitizing properties, and high adiponectin levels have been shown to be associated with reduced risk of developing diabetes. Patients with coronary artery disease (CAD) have relatively low adiponectin levels and high prevalence of glucose intolerance. The role of adiponectin in predicting the development of diabetes in this high-risk group has not been determined. The study aimed to determine whether baseline adiponectin levels predict the development of diabetes in a group of patients with CAD and impaired fasting glucose (IFG). Methods: A total of 588 patients who participated in the Bezafibrate Infarction Prevention (BIP) study and who had at baseline fasting glucose of 100 -125 mg/dl were included and followed for 6.2^1.3 years. Adiponectin was determined in frozen plasma samples taken at baseline. Results: Of the patients with IFG at baseline, 256 (44%) developed diabetes during follow-up. The patients who developed diabetes had at baseline higher body-mass index, fasting glucose, C-reactive protein, triglycerides, homeostatic assessment of insulin resistance (HOMA-IR) and diastolic blood pressure than patients who did not develop diabetes. Adiponectin levels at baseline were significantly lower in patients who developed diabetes than in patients who did not develop diabetes (P ¼ 0.009, nonparametric Kruskall -Wallis test). An increase of 1 unit of natural logarithm of adiponectin level was associated with a hazard ratio of 0.77 (95% CI, 0.61-0.96) for diabetes development. Conclusion: Patients with CAD and IFG have a very high rate of conversion to type 2 diabetes. Even in this high-risk group, high adiponectin levels are associated with reduced risk of developing diabetes.European Journal of Endocrinology 154 87-92

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Serum adiponectin is associated with high-density lipoprotein cholesterol, triglycerides, and low-density lipoprotein particle size in young healthy men

Cited by 111 publications

References 45 publications

The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes

The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes

LDL particle size, fat distribution and insulin resistance in obese children

Adiponectin and the development of diabetes in patients with coronary artery disease and impaired fasting glucose

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